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PATH classification: a proposal for patients with HNSCC treated with salvage surgery

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Názov: PATH classification: a proposal for patients with HNSCC treated with salvage surgery
Autori: Albert Llansana, David Virós Porcuna, Rosselin Vasquez, Arnau Parellada, Cristina Valero, Anna Holgado, Xavier León
Prispievatelia: Institut Català de la Salut, [Llansana A] Otorhinolaryngology Department, Hospital Mutua de Terrassa, Terrassa, Spain. [Virós Porcuna D] Servei d’Otorrinolaringologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Vasquez R, Parellada A, Valero C, Holgado A] Otorhinolaryngology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus
Zdroj: Eur Arch Otorhinolaryngol
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Informácie o vydavateľovi: Springer Science and Business Media LLC, 2024.
Rok vydania: 2024
Predmety: Male, Adult, ENFERMEDADES::neoplasias::neoplasias::neoplasias por localización::neoplasias de cabeza y cuello::carcinoma de células escamosas de cabeza y cuello, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::tratamiento de última línea, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Neoplasm Staging, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::estadificación de neoplasias, Metàstasi limfàtica, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Salvage Therapy, DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis::Lymphatic Metastasis, DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, Local, Càncer - Recaiguda, DISEASES::Neoplasms::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Squamous Cell Carcinoma of Head and Neck, Coll - Càncer - Cirurgia, Humans, Other subheadings::Other subheadings::Other subheadings::/surgery, Retrospective Studies, Aged, Neoplasm Staging, Salvage Therapy, Aged, 80 and over, Otros calificadores::Otros calificadores::Otros calificadores::/cirugía, ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica::metástasis linfática, Squamous Cell Carcinoma of Head and Neck, Margins of Excision, Cap - Càncer - Cirurgia, Middle Aged, Prognosis, Coll - Càncer - Prognosi, Head and Neck Neoplasms, Lymphatic Metastasis, Cap - Càncer - Prognosi, ENFERMEDADES::neoplasias::procesos neoplásicos::recurrencia neoplásica local, Carcinoma, Squamous Cell, Female, Neoplasm Recurrence, Local, Head and Neck
Popis: Purpose The aim of this study is to propose a classification for patients with recurrent head and neck squamous cell carcinoma (HNSCC) treated with salvage surgery based on the location of the primary tumor and data commonly found in the pathological report of the resection. Methods Retrospective study of 665 patients with HNSCC treated with a salvage surgery after a local and/or regional recurrence of the tumor. Results We propose a new postoperative classification for patients with recurrent HNSCC treated with salvage surgery. PATH classification stratifies patients into 4 stages based on the glottic or non-glottic location of the primary tumor, the local and regional pathologic extension of the tumor, the status of the surgical margins, and the presence of lymph node metastases with extracapsular spread. The PATH classification was more homogeneous in the prognosis of patients included in each of its stages, and it had a better prognostic discrimination capacity between stages than the rpTNM classification. According to the PATH classification, the 5-year disease-specific survival was: PATH I (n = 306) 82.8%; PATH II (n = 119) 47.1%; PATH III (n = 202) 24.4%; PATH IV (n = 38) 3.7%. For the rpTNM classification, the 5-year disease-specific survival was: stage I (n = 119) 85.1%; stage II (n = 134) 68.4%; stage III (n = 111) 59.5%; stage IV (n = 301) 33.3%. Conclusion The PATH classification for HNSCC patients with local and/or regional recurrence treated with salvage surgery had a better prognostic capacity than the rpTNM classification. Level of evidence Level IV.
Druh dokumentu: Article
Other literature type
Popis súboru: application/pdf
Jazyk: English
ISSN: 1434-4726
0937-4477
DOI: 10.1007/s00405-024-08961-x
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39312000
http://hdl.handle.net/11351/12704
Rights: CC BY
Prístupové číslo: edsair.doi.dedup.....e623aaafdba342d371e9b4b49b305201
Databáza: OpenAIRE
Popis
Abstrakt:Purpose The aim of this study is to propose a classification for patients with recurrent head and neck squamous cell carcinoma (HNSCC) treated with salvage surgery based on the location of the primary tumor and data commonly found in the pathological report of the resection. Methods Retrospective study of 665 patients with HNSCC treated with a salvage surgery after a local and/or regional recurrence of the tumor. Results We propose a new postoperative classification for patients with recurrent HNSCC treated with salvage surgery. PATH classification stratifies patients into 4 stages based on the glottic or non-glottic location of the primary tumor, the local and regional pathologic extension of the tumor, the status of the surgical margins, and the presence of lymph node metastases with extracapsular spread. The PATH classification was more homogeneous in the prognosis of patients included in each of its stages, and it had a better prognostic discrimination capacity between stages than the rpTNM classification. According to the PATH classification, the 5-year disease-specific survival was: PATH I (n = 306) 82.8%; PATH II (n = 119) 47.1%; PATH III (n = 202) 24.4%; PATH IV (n = 38) 3.7%. For the rpTNM classification, the 5-year disease-specific survival was: stage I (n = 119) 85.1%; stage II (n = 134) 68.4%; stage III (n = 111) 59.5%; stage IV (n = 301) 33.3%. Conclusion The PATH classification for HNSCC patients with local and/or regional recurrence treated with salvage surgery had a better prognostic capacity than the rpTNM classification. Level of evidence Level IV.
ISSN:14344726
09374477
DOI:10.1007/s00405-024-08961-x