How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence
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| Titel: | How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence |
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| Autoren: | Buentzel, Judith, Bauer, Christoph, Buentzel, Jens, Department of Haematology and Medical Oncology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany, Department of Nephrology and Hypertension, Center for Internal Medicine and Medical Clinic III, Fulda, Germany, Department of Otolaryngology, Head Neck Surgery, Südharz Hospital, Nordhausen, Germany |
| Weitere Verfasser: | Buentzel, Judith, Bauer, Christoph, Buentzel, Jens, Department of Haematology and Medical Oncology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany, Department of Nephrology and Hypertension, Center for Internal Medicine and Medical Clinic III, Fulda, Germany, Department of Otolaryngology, Head Neck Surgery, Südharz Hospital, Nordhausen, Germany |
| Quelle: | J Cancer Res Clin Oncol |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2020. |
| Publikationsjahr: | 2020 |
| Schlagwörter: | 2. Zero hunger, Stomatitis, Plants, Medicinal, Europe [MeSH], Antineoplastic Agents/adverse effects [MeSH], Systematic Reviews as Topic [MeSH], Original Article – Clinical Oncology, Phytotherapy/methods [MeSH], Humans [MeSH], Oral mucositis, |
| Beschreibung: | Purpose Oral mucositis is a common, painful side effect of cancer treatment—be it locoregional (e.g. irradiation) or systemic (e. g. chemotherapy). Phytotherapy is often used by patients to alleviate symptoms. However, knowledge on which medical plants are recommended by literature about Traditional European Medicine (TEM), their effect(s) on symptoms and their efficacy is severely lacking. Therefore, we developed a novel approach to assess traditional knowledge of herbals used in TEM and searched the online databases for studies reporting effects of these plants. Methods At first, online research did not yield a satisfying number of studies (MESH terms: “mucositis” OR “stomatitis” AND “herbal” OR “herbal medicine”). Trials were labelled by the country conducting the study. In parallel, we compiled a list of 78 plants recommended for treating oral mucositis by screening 14 books on TEM. Then, a “hit list” of the plants most often mentioned was composed and used further for a second online investigation using the Latin plant designations as MESH term. Studies of both online searches were pooled for analysis. Results There is a gap between traditional knowledge and trials investigating medical plants used by TEM. Overall, herbal remedies alleviate oral mucositis and especially, gingivitis well. There is good evidence for using Matricaria recutita L., Salvia officinalis L., Calendula officinalis L. and Thymus spp. L. for treating oral mucositis. Conclusion Clinical trials investigating medical plants known in TEM are rare. However, following our research strategy, we could extrapolate four plants with good evidence for alleviating symptoms of oral mucositis and gingivitis. |
| Publikationsart: | Article Other literature type |
| Sprache: | English |
| ISSN: | 1432-1335 0171-5216 |
| DOI: | 10.1007/s00432-020-03124-x |
| Zugangs-URL: | https://link.springer.com/content/pdf/10.1007/s00432-020-03124-x.pdf https://pubmed.ncbi.nlm.nih.gov/31955287 https://link.springer.com/article/10.1007/s00432-020-03124-x https://www.ncbi.nlm.nih.gov/pubmed/31955287 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085484 https://pubmed.ncbi.nlm.nih.gov/31955287/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085484 https://resolver.sub.uni-goettingen.de/purl?gro-2/70822 https://repository.publisso.de/resource/frl:6467422 |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....e57a1ee2d2b7d8876c5390940c9fae44 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Purpose Oral mucositis is a common, painful side effect of cancer treatment—be it locoregional (e.g. irradiation) or systemic (e. g. chemotherapy). Phytotherapy is often used by patients to alleviate symptoms. However, knowledge on which medical plants are recommended by literature about Traditional European Medicine (TEM), their effect(s) on symptoms and their efficacy is severely lacking. Therefore, we developed a novel approach to assess traditional knowledge of herbals used in TEM and searched the online databases for studies reporting effects of these plants. Methods At first, online research did not yield a satisfying number of studies (MESH terms: “mucositis” OR “stomatitis” AND “herbal” OR “herbal medicine”). Trials were labelled by the country conducting the study. In parallel, we compiled a list of 78 plants recommended for treating oral mucositis by screening 14 books on TEM. Then, a “hit list” of the plants most often mentioned was composed and used further for a second online investigation using the Latin plant designations as MESH term. Studies of both online searches were pooled for analysis. Results There is a gap between traditional knowledge and trials investigating medical plants used by TEM. Overall, herbal remedies alleviate oral mucositis and especially, gingivitis well. There is good evidence for using Matricaria recutita L., Salvia officinalis L., Calendula officinalis L. and Thymus spp. L. for treating oral mucositis. Conclusion Clinical trials investigating medical plants known in TEM are rare. However, following our research strategy, we could extrapolate four plants with good evidence for alleviating symptoms of oral mucositis and gingivitis. |
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| ISSN: | 14321335 01715216 |
| DOI: | 10.1007/s00432-020-03124-x |