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Synthesis and in vitro antitumor activity of an isomer of the marine pyridoacridine alkaloid ascididemin and related compounds

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Názov: Synthesis and in vitro antitumor activity of an isomer of the marine pyridoacridine alkaloid ascididemin and related compounds
Autori: Delfourne, Evelyne, Kiss, Robert, Le Corre, Laurent, Merza, Joumaa, Bastide, Jean, Frydman, Armand, Darro, Francis
Zdroj: Bioorganic & Medicinal Chemistry. 11:4351-4356
Informácie o vydavateľovi: Elsevier BV, 2003.
Rok vydania: 2003
Predmety: Alkaloids -- pharmacology, Acridines -- chemistry, Acridines -- pharmacology, Antineoplastic Agents -- chemical synthesis, Antineoplastic Agents, Marine Biology, Drug Screening Assays, 01 natural sciences, Cell Line, Antineoplastic Agents -- chemistry, Structure-Activity Relationship, Alkaloids, Antineoplastic Agents -- pharmacology, Isomerism, Cell Line, Tumor, Phenanthrolines -- chemistry, Quinolines -- chemistry, Quinolines -- pharmacology, Animals, Humans, Cell Division -- drug effects, Urochordata, Phenanthrolines -- chemical synthesis, Alkaloids -- chemistry, Phenanthrolines -- pharmacology, Tumor, Urochordata -- chemistry, Antitumor, Sciences bio-médicales et agricoles, 0104 chemical sciences, 3. Good health, Quinolines -- chemical synthesis, Quinolines, Acridines, Drug Screening Assays, Antitumor, Acridines -- chemical synthesis, Cell Division, Alkaloids -- chemical synthesis, Phenanthrolines
Popis: The isomer (9H-quino[4,3,2-de][1,7]phenanthroline-9-one) (2) of the marine alkaloid ascididemin (9H-quino[4,3,2-de][1,10]phenanthroline-9-one) (1) has been synthesized in six steps from 1,4-dimethoxyacridine (10) with an overall yield of 12%. Different related compounds were prepared and tested in vitro at six different concentrations on 12 different human cancer cell lines of various histopathological types (glioblastomas and breast, colon, lung, prostate and bladder cancers). Almost all the compounds present cytotoxic activity of micromolar order.
Druh dokumentu: Article
Popis súboru: No full-text files
Jazyk: English
ISSN: 0968-0896
DOI: 10.1016/s0968-0896(03)00483-8
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/13129571
https://www.ncbi.nlm.nih.gov/pubmed/13129571
http://www.sciencedirect.com/science/article/pii/S0968089603004838
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/52137/Details
https://www.sciencedirect.com/science/article/pii/S0968089603004838
Rights: Elsevier TDM
Prístupové číslo: edsair.doi.dedup.....e50d6a3394fe5ea6ef075e247d0b471d
Databáza: OpenAIRE
Popis
Abstrakt:The isomer (9H-quino[4,3,2-de][1,7]phenanthroline-9-one) (2) of the marine alkaloid ascididemin (9H-quino[4,3,2-de][1,10]phenanthroline-9-one) (1) has been synthesized in six steps from 1,4-dimethoxyacridine (10) with an overall yield of 12%. Different related compounds were prepared and tested in vitro at six different concentrations on 12 different human cancer cell lines of various histopathological types (glioblastomas and breast, colon, lung, prostate and bladder cancers). Almost all the compounds present cytotoxic activity of micromolar order.
ISSN:09680896
DOI:10.1016/s0968-0896(03)00483-8