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Association of the expression of Bcl-2 and Ki-67 prognostic markers and apoptotic index with biological behaviour in aggressive and non-aggressive non-melanoma eyelid skin cancer

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Titel: Association of the expression of Bcl-2 and Ki-67 prognostic markers and apoptotic index with biological behaviour in aggressive and non-aggressive non-melanoma eyelid skin cancer
Autoren: Prídavková, Zuzana, Plank, Lukáš, Žiak, Peter, Halička, Juraj, Benca-Kapitánová, Karolína, Vida, Rastislav, Bartoš, Vladimír
Quelle: Postepy Dermatol Alergol
Verlagsinformationen: Termedia Sp. z.o.o., 2024.
Publikationsjahr: 2024
Schlagwörter: Original Paper
Beschreibung: Prognostic biomarkers facilitate the identification of high-risk tumours.To evaluate the association of Bcl-2 protein and Ki-67 antigen expression and the apoptotic index with biological behaviour of non-melanoma eyelid tumours.Combined analysis of retrospective and prospective study of data from two centres over a period from 2008 to 2023 on histologically confirmed malignant non-melanoma eyelid tumours without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated.The study cohort included 68 patients with 70 non-melanoma eyelid tumours (n = 70). The basal cell carcinoma was the most frequently present type (97.1%). The median age was 68 years. A tumour size > 5 mm correlates to the aggressive type (p = 0.047). Resection margins < 2 mm were in 33.9%, without any connection to the recurrence rate (p = 0.076). The average value of Bcl-2 expression in non-aggressive types was 82.65% (p < 0.001). The value of Ki-67 expression in patients with non-aggressive tumours was 35.49% (p = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (p = 0.535). No Grade III case was observed in the aggressive types. In 2 cases, the orbital exenteration was carried out (0.03%). In 1 case biological therapy was administered. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 (0.06%) cases.New information on cancer biomarkers in non-melanoma eyelid skin carcinoma contributes to choosing a correct therapy with achieving good aesthetic results and a good survival rate.
Publikationsart: Article
Other literature type
ISSN: 1642-395X
DOI: 10.5114/ada.2024.144402
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39606595
Rights: URL: http://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Dokumentencode: edsair.doi.dedup.....e40fa437ad19b27e1d4b95ef1e2b5721
Datenbank: OpenAIRE
Beschreibung
Abstract:Prognostic biomarkers facilitate the identification of high-risk tumours.To evaluate the association of Bcl-2 protein and Ki-67 antigen expression and the apoptotic index with biological behaviour of non-melanoma eyelid tumours.Combined analysis of retrospective and prospective study of data from two centres over a period from 2008 to 2023 on histologically confirmed malignant non-melanoma eyelid tumours without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated.The study cohort included 68 patients with 70 non-melanoma eyelid tumours (n = 70). The basal cell carcinoma was the most frequently present type (97.1%). The median age was 68 years. A tumour size > 5 mm correlates to the aggressive type (p = 0.047). Resection margins < 2 mm were in 33.9%, without any connection to the recurrence rate (p = 0.076). The average value of Bcl-2 expression in non-aggressive types was 82.65% (p < 0.001). The value of Ki-67 expression in patients with non-aggressive tumours was 35.49% (p = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (p = 0.535). No Grade III case was observed in the aggressive types. In 2 cases, the orbital exenteration was carried out (0.03%). In 1 case biological therapy was administered. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 (0.06%) cases.New information on cancer biomarkers in non-melanoma eyelid skin carcinoma contributes to choosing a correct therapy with achieving good aesthetic results and a good survival rate.
ISSN:1642395X
DOI:10.5114/ada.2024.144402