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Elevation of Mac‐2 binding protein glycosylation isomer after hepatectomy is associated with post‐hepatectomy liver failure, total Pringle time, and renal dysfunction

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Title: Elevation of Mac‐2 binding protein glycosylation isomer after hepatectomy is associated with post‐hepatectomy liver failure, total Pringle time, and renal dysfunction
Authors: Daisuke Imai, Takashi Maeda, Huanlin Wang, Kensaku Sanefuji, Hiroto Kayashima, Shohei Yoshiya, Kazuki Takeishi, Shinji Itoh, Noboru Harada, Toru Ikegami, Tomoharu Yoshizumi, Masaki Mori
Source: Ann Gastroenterol Surg
Annals of Gastroenterological Surgery, Vol 3, Iss 5, Pp 515-522 (2019)
Publisher Information: Wiley, 2019.
Publication Year: 2019
Subject Terms: 0301 basic medicine, 0303 health sciences, RD1-811, RC799-869, Original Articles, Diseases of the digestive system. Gastroenterology, 3. Good health, Pringle maneuver, 03 medical and health sciences, renal dysfunction, liver resection, Mac‐2 binding protein glycosylation isomer, post‐hepatectomy liver failure, Surgery
Description: BackgroundMac‐2 binding protein glycosylation isomer (M2BPGi) is a novel serum glycomarker used to assess liver fibrosis. However, it has been reported that M2BPGi is likely to reflect other factors not limited to liver fibrosis.MethodsWe retrospectively analyzed 79 patients with liver tumors who underwent liver resection. M2BPGi was measured within 1 week before operation and almost 1 month after operation. We introduced a value termed the “ΔM2BPGi ratio” (=M2BPGiafter operation/M2BPGibefore operation), and analyzed factors that influenced the ΔM2BPGi ratio.ResultsThe median value of the ΔM2BPGi ratio was 1.28 (range, 0.36‐5.68). In 64 patients (81.0%), the cutoff index values of M2BPGi were elevated approximately 1 month after operation, especially in patients who experienced post‐hepatectomy liver failure (PHLF). Multiple linear regression showed total Pringle time, PHLF grade ≥B, and preoperative value of creatinine were significant predictors of the ΔM2BPGi ratio. The mean values of the ΔM2BPGi ratio were 1.37 ± 0.07, 1.52 ± 0.22, and 2.94 ± 0.30 for PHLF grade 0, grade A, and grade B, respectively, resulting in statistically significant differences by the Kruskal‐Wallis test (P = 0.022).ConclusionsTotal Pringle time, PHLF grade ≥B, and preoperative creatinine significantly influenced the elevation of M2BPGi almost 1 month after liver resection. This study strongly affirms the previous suggestion that M2BPGi is likely to reflect other factors not limited to liver fibrosis.
Document Type: Article
Other literature type
Language: English
ISSN: 2475-0328
DOI: 10.1002/ags3.12271
Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ags3.12271
https://pubmed.ncbi.nlm.nih.gov/31549011
https://doaj.org/article/6bdf2ef3407940cb9388c213238130da
https://kyushu-u.pure.elsevier.com/en/publications/elevation-of-mac-2-binding-protein-glycosylation-isomer-after-hep
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ags3.12271
https://pubmed.ncbi.nlm.nih.gov/31549011/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749955/
https://onlinelibrary.wiley.com/doi/full/10.1002/ags3.12271
Rights: CC BY
Accession Number: edsair.doi.dedup.....e19ca3e5e927caa7c94a1d33dceb4195
Database: OpenAIRE
Description
Abstract:BackgroundMac‐2 binding protein glycosylation isomer (M2BPGi) is a novel serum glycomarker used to assess liver fibrosis. However, it has been reported that M2BPGi is likely to reflect other factors not limited to liver fibrosis.MethodsWe retrospectively analyzed 79 patients with liver tumors who underwent liver resection. M2BPGi was measured within 1 week before operation and almost 1 month after operation. We introduced a value termed the “ΔM2BPGi ratio” (=M2BPGiafter operation/M2BPGibefore operation), and analyzed factors that influenced the ΔM2BPGi ratio.ResultsThe median value of the ΔM2BPGi ratio was 1.28 (range, 0.36‐5.68). In 64 patients (81.0%), the cutoff index values of M2BPGi were elevated approximately 1 month after operation, especially in patients who experienced post‐hepatectomy liver failure (PHLF). Multiple linear regression showed total Pringle time, PHLF grade ≥B, and preoperative value of creatinine were significant predictors of the ΔM2BPGi ratio. The mean values of the ΔM2BPGi ratio were 1.37 ± 0.07, 1.52 ± 0.22, and 2.94 ± 0.30 for PHLF grade 0, grade A, and grade B, respectively, resulting in statistically significant differences by the Kruskal‐Wallis test (P = 0.022).ConclusionsTotal Pringle time, PHLF grade ≥B, and preoperative creatinine significantly influenced the elevation of M2BPGi almost 1 month after liver resection. This study strongly affirms the previous suggestion that M2BPGi is likely to reflect other factors not limited to liver fibrosis.
ISSN:24750328
DOI:10.1002/ags3.12271