European-wide antimicrobial resistance monitoring in commensal Escherichia coli isolated from healthy food animals between 2004 and 2018
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| Názov: | European-wide antimicrobial resistance monitoring in commensal Escherichia coli isolated from healthy food animals between 2004 and 2018 |
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| Autori: | Anno De Jong, Farid El Garch, Didier Hocquet, Ellen Prenger-Berninghoff, Jeroen Dewulf, Lourdes Migura-Garcia, Agnès Perrin-Guyomard, Kees T Veldman, Szilard Janosi, Magdalena Skarzynska, Shabbir Simjee, Hilde Moyaert, Markus Rose, Marion Ocak, Pascal Butty, Rebecca Klee, Guido Schiffer, Clelia Stevenin, Pieter-Jan Serreyn, Robin Temmerman |
| Prispievatelia: | Producció Animal, Sanitat Animal, Centre européen d'études pour la santé animale (CEESA), Vetoquinol SA, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Universiteit Gent = Ghent University = Université de Gand (UGENT), Centre de Recerca en Sanitat Animal UAB, Spain (CReSA), Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona (UAB)-Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA), Laboratoire de Fougères - ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Wageningen BioVeterinary Research, Wageningen University and Research Wageningen (WUR), National Food Chain Safety Office (NEBIH), National Veterinary Research Institute Pulawy, Pologne (NVRI), Elanco Animal Health, Zoetis, MSD Animal Health Schwabenheim, This work was supported by the EASSA (European Antimicrobial Susceptibility Surveillance in Animals) Study Group members: Bayer, Ceva, Elanco, Huvepharma, Merial, MSD, Vetoquinol, Virbac and Zoetis. No other external funding was received. |
| Zdroj: | IRTA Pubpro. Open Digital Archive Institut de Recerca i Tecnologia Agroalimentàries (IRTA) JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY |
| Informácie o vydavateľovi: | Oxford University Press (OUP), 2022. |
| Rok vydania: | 2022 |
| Predmety: | 0301 basic medicine, antibiotic resistance, Swine, food animal, résistance aux antibiotiques, SUSCEPTIBILITY, CEPHALOSPORINS, Ciprofloxacin, bacteria, MESH: Swine, Escherichia coli Infections, bactérie, 2. Zero hunger, MESH: Microbial Sensitivity Tests, Sulfamethoxazole Drug Combination, MESH: Escherichia coli, MESH: Trimethoprim, Bacterial, MESH: Chickens, Anti-Bacterial Agents, 3. Good health, Europe, MESH: Cattle, sécurité alimentaire, BACTERIA, surveillance, MESH: Drug Resistance, enquête, Microbial Sensitivity Tests, 03 medical and health sciences, résistance aux antimicrobiens, MESH: Anti-Bacterial Agents, Drug Resistance, Bacterial, Trimethoprim, Sulfamethoxazole Drug Combination, Escherichia coli, Life Science, Humans, Animals, survey, antimicrobial resistance, MESH: Ciprofloxacin, Veterinary Sciences, microbiologie, MESH: Escherichia coli Infections, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, microbiology, monitoring, Cattle, Ampicillin, MESH: Ampicillin, Chickens |
| Popis: | Objectives To describe the susceptibility of Escherichia coli to medically important antibiotics, collected over four periods (2004–2006, 2008–2009, 2013–2014, 2017–2018), from food-producing animals at slaughter. Methods Intestinal contents from cattle, pigs and broilers were randomly sampled (5–6 countries/host; ≥4 abattoirs/country; one sample/animal/farm) for isolation of Escherichia coli; antimicrobial susceptibilities were centrally determined by CLSI agar dilution. Clinical breakpoints (CLSI) and epidemiological cut-off values (EUCAST) were applied for data interpretation. Results In total, 10 613 E. coli strains were recovered. In broilers, resistance percentages were the lowest (P ≤ 0.01) in the latest time period. A significant decrease in MDR over time was also observed for broilers and a tendency for a decrease for pigs. Resistance to meropenem and tigecycline was absent, and resistance to azithromycin was 0.2%–2.0%. Also, low resistance to third-generation cephalosporins (1.1%–7.4%) was detected in broilers. Resistance to colistin varied between 0.1%–4.8%. E. coli from broilers showed high resistance to ciprofloxacin (7.3%–23.3%), whereas for cattle and pigs this was 0.2%–2.5%. Low/moderate resistance to chloramphenicol (9.3%–21.3%) and gentamicin (0.9%–7.0%) was observed in pigs and broilers. The highest resistance was noted for ampicillin (32.7%–65.3%), tetracycline (41.3%–67.5%), trimethoprim (32.0%–35.7%) and trimethoprim/sulfamethoxazole (27.5%–49.7%) from pigs and broilers, with marked country differences. MDR peaked in pigs and broilers with 24 and 26 phenotypes, with 21.9%–26.2% and 18.7%–34.1% resistance, respectively. Conclusions In this pan-EU survey antibiotic susceptibility of commensal E. coli varied largely between antibiotics, animal species and countries. Resistance to critically important antibiotics for human medicine was absent or low, except for ciprofloxacin in broilers and ampicillin in pigs and broilers. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dkac318 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/36203261 https://research.wur.nl/en/publications/european-wide-antimicrobial-resistance-monitoring-in-commensal-es https://doi.org/10.1093/jac/dkac318 https://biblio.ugent.be/publication/8771393 http://doi.org/10.1093/jac/dkac318 https://biblio.ugent.be/publication/8771393/file/8771395 http://hdl.handle.net/1854/LU-8771393 |
| Rights: | OUP Standard Publication Reuse |
| Prístupové číslo: | edsair.doi.dedup.....e1679aa48014f59f711319d0a1f90b41 |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Objectives To describe the susceptibility of Escherichia coli to medically important antibiotics, collected over four periods (2004–2006, 2008–2009, 2013–2014, 2017–2018), from food-producing animals at slaughter. Methods Intestinal contents from cattle, pigs and broilers were randomly sampled (5–6 countries/host; ≥4 abattoirs/country; one sample/animal/farm) for isolation of Escherichia coli; antimicrobial susceptibilities were centrally determined by CLSI agar dilution. Clinical breakpoints (CLSI) and epidemiological cut-off values (EUCAST) were applied for data interpretation. Results In total, 10 613 E. coli strains were recovered. In broilers, resistance percentages were the lowest (P ≤ 0.01) in the latest time period. A significant decrease in MDR over time was also observed for broilers and a tendency for a decrease for pigs. Resistance to meropenem and tigecycline was absent, and resistance to azithromycin was 0.2%–2.0%. Also, low resistance to third-generation cephalosporins (1.1%–7.4%) was detected in broilers. Resistance to colistin varied between 0.1%–4.8%. E. coli from broilers showed high resistance to ciprofloxacin (7.3%–23.3%), whereas for cattle and pigs this was 0.2%–2.5%. Low/moderate resistance to chloramphenicol (9.3%–21.3%) and gentamicin (0.9%–7.0%) was observed in pigs and broilers. The highest resistance was noted for ampicillin (32.7%–65.3%), tetracycline (41.3%–67.5%), trimethoprim (32.0%–35.7%) and trimethoprim/sulfamethoxazole (27.5%–49.7%) from pigs and broilers, with marked country differences. MDR peaked in pigs and broilers with 24 and 26 phenotypes, with 21.9%–26.2% and 18.7%–34.1% resistance, respectively. Conclusions In this pan-EU survey antibiotic susceptibility of commensal E. coli varied largely between antibiotics, animal species and countries. Resistance to critically important antibiotics for human medicine was absent or low, except for ciprofloxacin in broilers and ampicillin in pigs and broilers. |
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| ISSN: | 14602091 03057453 |
| DOI: | 10.1093/jac/dkac318 |