Advanced imaging reveals enhanced malignancy in glioblastomas involving the subventricular zone: evidence of increased infiltrative growth and perfusion
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| Titel: | Advanced imaging reveals enhanced malignancy in glioblastomas involving the subventricular zone: evidence of increased infiltrative growth and perfusion |
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| Autoren: | Griessmair, Michael, Schramm, Severin, Ziegenfeuter, Julian, Canisius, Julian, Jung, Kirsten, Delbridge, Claire, Schmidt-Graf, Friederike, Mitsdoerffer, Meike, Zimmer, Claus, Meyer, Bernhard, Metz, Marie-Christin, Wiestler, Benedikt |
| Quelle: | J Neurooncol |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2024. |
| Publikationsjahr: | 2024 |
| Schlagwörter: | Male, Adult, Brain Neoplasms, Research, Middle Aged, Magnetic Resonance Imaging, ddc, Advanced imaging biomarkers, Tumorigenesis of glioblastoma, Fully automated tumor segmentations, 850k methylation analysis, Diffusion Magnetic Resonance Imaging, Female [MeSH], Aged [MeSH], Adult [MeSH], Humans [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Glioblastoma/pathology [MeSH], Male [MeSH], Lateral Ventricles/diagnostic imaging [MeSH], Diffusion Magnetic Resonance Imaging [MeSH], Magnetic Resonance Imaging/methods [MeSH], Brain Neoplasms/diagnostic imaging [MeSH], Glioblastoma/diagnostic imaging [MeSH], Lateral Ventricles/pathology [MeSH], Brain Neoplasms/pathology [MeSH], Lateral Ventricles, Humans, Female, Glioblastoma, Retrospective Studies, Aged |
| Beschreibung: | Background Glioblastoma’s infiltrative growth and heterogeneity are influenced by neural, molecular, genetic, and immunological factors, with the precise origin of these tumors remaining elusive. Neurogenic zones might serve as the tumor stem cells’ nest, with tumors in contact with these zones exhibiting worse outcomes and more aggressive growth patterns. This study aimed to determine if these characteristics are reflected in advanced imaging, specifically diffusion and perfusion data. Methods In this monocentric retrospective study, 137 glioblastoma therapy-naive patients (IDH-wildtype, grade 4) with advanced preoperative MRI, including perfusion and diffusion imaging, were analyzed. Tumors and neurogenic zones were automatically segmented. Advanced imaging metrics, including cerebral blood volume (CBV) from perfusion imaging, tissue volume mask (TVM), and free water corrected fractional anisotropy (FA-FWE) from diffusion imaging, were extracted. Results SVZ infiltration positively correlated with CBV, indicating higher perfusion in tumors. Significant CBV differences were noted between high and low SVZ infiltration cases at specific percentiles. Negative correlation was observed with TVM and positive correlation with FA-FWE, suggesting more infiltrative tumor growth. Significant differences in TVM and FA-FWE values were found between high and low SVZ infiltration cases. Discussion Glioblastomas with SVZ infiltration exhibit distinct imaging characteristics, including higher perfusion and lower cell density per voxel, indicating a more infiltrative growth and higher vascularization. Stem cell-like characteristics in SVZ-infiltrating cells could explain the increased infiltration and aggressive behavior. Understanding these imaging and biological correlations could enhance the understanding of glioblastoma evolution. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-024-04849-2 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/39387957 https://repository.publisso.de/resource/frl:6500479 https://mediatum.ub.tum.de/1770656 |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....df4f837fdb432691d9c2955cb309aaf1 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Background Glioblastoma’s infiltrative growth and heterogeneity are influenced by neural, molecular, genetic, and immunological factors, with the precise origin of these tumors remaining elusive. Neurogenic zones might serve as the tumor stem cells’ nest, with tumors in contact with these zones exhibiting worse outcomes and more aggressive growth patterns. This study aimed to determine if these characteristics are reflected in advanced imaging, specifically diffusion and perfusion data. Methods In this monocentric retrospective study, 137 glioblastoma therapy-naive patients (IDH-wildtype, grade 4) with advanced preoperative MRI, including perfusion and diffusion imaging, were analyzed. Tumors and neurogenic zones were automatically segmented. Advanced imaging metrics, including cerebral blood volume (CBV) from perfusion imaging, tissue volume mask (TVM), and free water corrected fractional anisotropy (FA-FWE) from diffusion imaging, were extracted. Results SVZ infiltration positively correlated with CBV, indicating higher perfusion in tumors. Significant CBV differences were noted between high and low SVZ infiltration cases at specific percentiles. Negative correlation was observed with TVM and positive correlation with FA-FWE, suggesting more infiltrative tumor growth. Significant differences in TVM and FA-FWE values were found between high and low SVZ infiltration cases. Discussion Glioblastomas with SVZ infiltration exhibit distinct imaging characteristics, including higher perfusion and lower cell density per voxel, indicating a more infiltrative growth and higher vascularization. Stem cell-like characteristics in SVZ-infiltrating cells could explain the increased infiltration and aggressive behavior. Understanding these imaging and biological correlations could enhance the understanding of glioblastoma evolution. |
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| ISSN: | 15737373 0167594X |
| DOI: | 10.1007/s11060-024-04849-2 |