View in EDS

Distinguishing glioblastoma progression from treatment-related changes using DTI directionality growth analysis

Saved in:
Bibliographic Details
Title: Distinguishing glioblastoma progression from treatment-related changes using DTI directionality growth analysis
Authors: R. van den Elshout, B. Ariëns, M. Esmaeili, B. Akkurt, M. Mannil, F. J. A. Meijer, A. G. van der Kolk, T. W. J. Scheenen, D. Henssen
Source: Neuroradiology
Neuroradiology, 66, 12, pp. 2143-2151
Publisher Information: Springer Science and Business Media LLC, 2024.
Publication Year: 2024
Subject Terms: Male, Adult, Brain Neoplasms, glioblastoma, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750, Contrast Media, Middle Aged, Female [MeSH], Disease Progression [MeSH], Aged [MeSH], Adult [MeSH], Humans [MeSH], Diffusion Tensor Imaging/methods [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], DTI, MRI, Glioblastoma/pathology [MeSH], Satellitosis, Contrast Media [MeSH], Glioblastoma, Glioblastoma/therapy [MeSH], Diagnosis, Differential [MeSH], Male [MeSH], Image Interpretation, Computer-Assisted/methods [MeSH], Lesion development, Brain Neoplasms/diagnostic imaging [MeSH], Glioblastoma/diagnostic imaging [MeSH], Diagnostic Neuroradiology, Brain Neoplasms/pathology [MeSH], Diagnosis, Differential, 03 medical and health sciences, Diffusion Tensor Imaging, 0302 clinical medicine, Medical Imaging - Radboud University Medical Center, Image Interpretation, Computer-Assisted, Disease Progression, Humans, Female, Aged, Retrospective Studies
Description: Background It is difficult to distinguish between tumor progression (TP) and treatment-related abnormalities (TRA) in treated glioblastoma patients via conventional MRI, but this distinction is crucial for treatment decision making. Glioblastoma is known to exhibit an invasive growth pattern along white matter architecture and vasculature. This study quantified lesion development patterns in treated glioblastoma lesions and their relation to white matter microstructure to distinguish TP from TRA. Materials and methods Glioblastoma patients with confirmed TP or TRA with T1-weighted contrast-enhanced and DTI MR scans from two posttreatment follow-up timepoints were reviewed. The contrast-enhancing regions were segmented, and the regions were coregistered to the DTI data. Lesion increase vectors were categorized into two groups: parallel (0–20 degrees) and perpendicular (70–90 degrees) to white matter. FA-values were also extracted. To test for a statistically significant difference between the TP and TRA groups, a Mann‒Whitney U test was performed. Results Of 73 glioblastoma patients, fifteen were diagnosed with TRA, whereas 58 patients suffered TP. TP had a 25.8% (95% CI 24.1%-27.6%) increase in parallel lesions, and TRA had a 25.4% (95% CI 20.9%-29.9%) increase in parallel lesions. The perpendicular increase was 14.7% for TP (95% CI 13.0%-16.4%) and 18.0% (95% CI 13.5%-22.5%) for TRA. These results were not significantly different (p = 0.978). FA value for TP showed to be 0.248 (SD = 0.054) and for TRA it was 0.231 (SD = 0.075), showing no statistically significant difference (p = 0.121). Conclusions Based on our results, quantifying posttreatment contrast-enhancing lesion development directionality with DTI in glioblastoma patients does not appear to effectively distinguish between TP and TRA.
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1432-1920
0028-3940
DOI: 10.1007/s00234-024-03450-8
Access URL: https://pubmed.ncbi.nlm.nih.gov/39153088
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/313328
https://repository.ubn.ru.nl//bitstream/handle/2066/313328/313328.pdf
https://hdl.handle.net/2066/313328
https://hdl.handle.net/11250/3170975
https://repository.publisso.de/resource/frl:6522474
Rights: CC BY
Accession Number: edsair.doi.dedup.....dec1d97d9c6a1ecd1581f6151edee9de
Database: OpenAIRE
Description
Abstract:Background It is difficult to distinguish between tumor progression (TP) and treatment-related abnormalities (TRA) in treated glioblastoma patients via conventional MRI, but this distinction is crucial for treatment decision making. Glioblastoma is known to exhibit an invasive growth pattern along white matter architecture and vasculature. This study quantified lesion development patterns in treated glioblastoma lesions and their relation to white matter microstructure to distinguish TP from TRA. Materials and methods Glioblastoma patients with confirmed TP or TRA with T1-weighted contrast-enhanced and DTI MR scans from two posttreatment follow-up timepoints were reviewed. The contrast-enhancing regions were segmented, and the regions were coregistered to the DTI data. Lesion increase vectors were categorized into two groups: parallel (0–20 degrees) and perpendicular (70–90 degrees) to white matter. FA-values were also extracted. To test for a statistically significant difference between the TP and TRA groups, a Mann‒Whitney U test was performed. Results Of 73 glioblastoma patients, fifteen were diagnosed with TRA, whereas 58 patients suffered TP. TP had a 25.8% (95% CI 24.1%-27.6%) increase in parallel lesions, and TRA had a 25.4% (95% CI 20.9%-29.9%) increase in parallel lesions. The perpendicular increase was 14.7% for TP (95% CI 13.0%-16.4%) and 18.0% (95% CI 13.5%-22.5%) for TRA. These results were not significantly different (p = 0.978). FA value for TP showed to be 0.248 (SD = 0.054) and for TRA it was 0.231 (SD = 0.075), showing no statistically significant difference (p = 0.121). Conclusions Based on our results, quantifying posttreatment contrast-enhancing lesion development directionality with DTI in glioblastoma patients does not appear to effectively distinguish between TP and TRA.
ISSN:14321920
00283940
DOI:10.1007/s00234-024-03450-8