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Muscle strength and osteoarthritis of the knee: a systematic review and meta-analysis of longitudinal studies: a systematic review and meta-analysis of longitudinal studies

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Title: Muscle strength and osteoarthritis of the knee: a systematic review and meta-analysis of longitudinal studies: a systematic review and meta-analysis of longitudinal studies
Authors: Patterson, Brooke E., Girdwood, Michael A., West, Thomas J., Bruder, Andrea M., Øiestad, Britt Elin, Juhl, Carsten, Culvenor, Adam G.
Source: Skeletal Radiology. 52:2085-2097
Publisher Information: Springer Science and Business Media LLC, 2022.
Publication Year: 2022
Subject Terms: Male, Adult, Knee Joint, Muscle strength, Middle Aged, Osteoarthritis, Knee, Knee/diagnostic imaging, Knee Joint/diagnostic imaging, Imaging, Radiography, 03 medical and health sciences, Magnetic resonance imaging, 0302 clinical medicine, Osteoarthritis, Muscle Strength/physiology, Humans, Female, Knee, Knee osteoarthritis, Longitudinal Studies, Muscle Strength, Bone Diseases, Aged
Description: To evaluate the sex-specific association between low knee extensor and flexor muscle strength and the risk of knee structural worsening.Systematic searches in five databases identified longitudinal studies (≥ 1 year follow-up) reporting an association between knee extensor or flexor strength and structural decline in individuals with, or at risk of, knee osteoarthritis. Results were pooled for tibiofemoral and patellofemoral osteoarthritis worsening (and stratified by sex/gender where possible) using a random-effects meta-analysis estimating the risk ratio and 95% confidence interval or a best-evidence synthesis. Risk of bias and overall certainty of evidence were assessed.Fourteen studies were included with participants (mean age 27-72 years) with osteoarthritis (n = 8), at risk of osteoarthritis (n = 3), or a combination with, or at risk of, osteoarthritis (n = 3). Low knee extensor strength was associated with an increased risk of worsening tibiofemoral (12 studies: RR 1.18, 95% CI 1.04 to 1.35) and patellofemoral osteoarthritis (4 studies: RR 1.62, 95% CI 1.01 to 2.61). Significant associations between low knee extensor strength and worsening tibiofemoral osteoarthritis were observed for women (4 studies: RR 1.25, 95% CI 1.04 to 1.51) but not men (4 studies: RR 1.10, 95% CI 0.87 to 1.39). Low knee flexor strength increased the risk of worsening tibiofemoral osteoarthritis (5 studies: RR 1.16, 95% CI 1.07 to 1.26). Ten studies were high risk of bias, and all estimates were graded as very low certainty of evidence.Low knee extensor and flexor strength increased the risk of worsening tibiofemoral osteoarthritis. Low knee extensor strength increased the risk of worsening patellofemoral osteoarthritis. The relationship between low knee extensor strength and worsening tibiofemoral osteoarthritis may be modified by sex/gender.
Document Type: Article
Language: English
ISSN: 1432-2161
0364-2348
DOI: 10.1007/s00256-022-04266-4
Access URL: https://pubmed.ncbi.nlm.nih.gov/36562820
Rights: Springer Nature TDM
Accession Number: edsair.doi.dedup.....dd938b8b484b7132c99c0dd3d69df30e
Database: OpenAIRE
Description
Abstract:To evaluate the sex-specific association between low knee extensor and flexor muscle strength and the risk of knee structural worsening.Systematic searches in five databases identified longitudinal studies (≥ 1 year follow-up) reporting an association between knee extensor or flexor strength and structural decline in individuals with, or at risk of, knee osteoarthritis. Results were pooled for tibiofemoral and patellofemoral osteoarthritis worsening (and stratified by sex/gender where possible) using a random-effects meta-analysis estimating the risk ratio and 95% confidence interval or a best-evidence synthesis. Risk of bias and overall certainty of evidence were assessed.Fourteen studies were included with participants (mean age 27-72 years) with osteoarthritis (n = 8), at risk of osteoarthritis (n = 3), or a combination with, or at risk of, osteoarthritis (n = 3). Low knee extensor strength was associated with an increased risk of worsening tibiofemoral (12 studies: RR 1.18, 95% CI 1.04 to 1.35) and patellofemoral osteoarthritis (4 studies: RR 1.62, 95% CI 1.01 to 2.61). Significant associations between low knee extensor strength and worsening tibiofemoral osteoarthritis were observed for women (4 studies: RR 1.25, 95% CI 1.04 to 1.51) but not men (4 studies: RR 1.10, 95% CI 0.87 to 1.39). Low knee flexor strength increased the risk of worsening tibiofemoral osteoarthritis (5 studies: RR 1.16, 95% CI 1.07 to 1.26). Ten studies were high risk of bias, and all estimates were graded as very low certainty of evidence.Low knee extensor and flexor strength increased the risk of worsening tibiofemoral osteoarthritis. Low knee extensor strength increased the risk of worsening patellofemoral osteoarthritis. The relationship between low knee extensor strength and worsening tibiofemoral osteoarthritis may be modified by sex/gender.
ISSN:14322161
03642348
DOI:10.1007/s00256-022-04266-4