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18F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD)

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Titel: 18F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD)
Autoren: Roll, W. (Wolfgang), Schindler, P. (Philipp), Masthoff, M. (Max), Strotmann, R. (Rebecca), Albring, J.C. (Jörn), Reicherts, C. (Christian), Weckesser, M. (Matthias), Noto, B. (Benjamin), Stelljes, M. (Matthias), Schäfers, M. (Michael), Evers, G.H. (Georg)
Weitere Verfasser: Universitäts- und Landesbibliothek Münster
Quelle: BMC Cancer
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
Verlagsinformationen: Springer Science and Business Media LLC, 2021.
Publikationsjahr: 2021
Schlagwörter: Adult, Male, FDG, 610 Medicine and health, Graft vs Host Disease, Allografts [MeSH], Aged [MeSH], Radiopharmaceuticals [MeSH], Fluorodeoxyglucose F18 [MeSH], PET-MRI, Acute Disease [MeSH], Positron-Emission Tomography/methods [MeSH], Male [MeSH], Stem Cell Transplantation/adverse effects [MeSH], GvHD, Graft vs Host Disease/diagnostic imaging [MeSH], Female [MeSH], Adult [MeSH], Reference Standards [MeSH], Humans [MeSH], Inflammation, Multimodal Imaging/methods [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Whole Body Imaging/methods [MeSH], Multimodal Imaging/statistics, Reproducibility of Results [MeSH], Research, Intestinal Diseases/diagnostic imaging [MeSH], Magnetic Resonance Imaging/methods [MeSH], Magnetic Resonance Imaging/statistics, Positron-Emission Tomography/statistics, Multimodal Imaging, 03 medical and health sciences, 0302 clinical medicine, Fluorodeoxyglucose F18, Humans, Whole Body Imaging, ddc:610, RC254-282, Aged, Retrospective Studies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Reproducibility of Results, Middle Aged, Reference Standards, Allografts, Magnetic Resonance Imaging, 3. Good health, Intestinal Diseases, Positron-Emission Tomography, Medicine and health, Acute Disease, Female, Radiopharmaceuticals, Stem Cell Transplantation
Beschreibung: Background Graft versus host disease (GvHD) is a frequent complication of allogeneic stem cell transplantation (alloSCT), significantly increasing mortality. Previous imaging studies focused on the assessment of intestinal GvHD with contrast-enhanced MRI/CT or 18F-FDG-PET imaging alone. The objective of this retrospective study was to elucidate the diagnostic value of a combined 18F-FDG-PET-MRI protocol in patients with acute intestinal GvHD. Methods Between 2/2015 and 8/2019, 21 patients with acute intestinal GvHD underwent 18F-FDG-PET-MRI. PET, MRI and PET-MRI datasets were independently reviewed. Readers assessed the number of affected segments of the lower gastrointestinal tract and the reliability of the diagnosis on a 5-point Likert scale and quantitative PET (SUVmax, SUVpeak, metabolic volume (MV)) and MRI parameter (wall thickness), were correlated to clinical staging of acute intestinal GvHD. Results The detection rate for acute intestinal GvHD was 56.8% for PET, 61.4% for MRI and 100% for PET-MRI. PET-MRI (median Likert-scale value: 5; range: 4–5) offers a significantly higher reliability of the diagnosis compared to PET (median: 4; range: 2–5; p = 0.01) and MRI alone (median: 4; range: 3–5; p = 0.03). The number of affected segments in PET-MRI (rs = 0.677; p s = 0.703; p < 0.001) correlated significantly with the clinical stage. SUVmax (rs = 0.345; p = 0.14), SUVpeak (rs = 0.276; p = 0.24) and wall thickening (rs = 0.174; p = 0.17) did not show a significant correlation to clinical stage. Conclusion 18F-FDG-PET-MRI allows for highly reliable assessment of acute intestinal GvHD and adds information indicating clinical severity.
Publikationsart: Article
Conference object
Other literature type
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 1471-2407
DOI: 10.1186/s12885-021-08748-x
DOI: 10.17879/30089534579
Zugangs-URL: https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-021-08748-x
https://pubmed.ncbi.nlm.nih.gov/34507549
https://doaj.org/article/e3b45aa8e4bf404bb6835b9924635441
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-08748-x
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434740
https://pubmed.ncbi.nlm.nih.gov/34507549/
https://europepmc.org/article/PMC/PMC8434740
https://repository.publisso.de/resource/frl:6463181
https://repositorium.uni-muenster.de/transfer/miami/6c4996be-0112-4dd4-8300-f7c41521e43a
Rights: CC BY
Dokumentencode: edsair.doi.dedup.....dd88646e595b16c5dfdfb7aeac10bc0e
Datenbank: OpenAIRE
Beschreibung
Abstract:Background Graft versus host disease (GvHD) is a frequent complication of allogeneic stem cell transplantation (alloSCT), significantly increasing mortality. Previous imaging studies focused on the assessment of intestinal GvHD with contrast-enhanced MRI/CT or 18F-FDG-PET imaging alone. The objective of this retrospective study was to elucidate the diagnostic value of a combined 18F-FDG-PET-MRI protocol in patients with acute intestinal GvHD. Methods Between 2/2015 and 8/2019, 21 patients with acute intestinal GvHD underwent 18F-FDG-PET-MRI. PET, MRI and PET-MRI datasets were independently reviewed. Readers assessed the number of affected segments of the lower gastrointestinal tract and the reliability of the diagnosis on a 5-point Likert scale and quantitative PET (SUVmax, SUVpeak, metabolic volume (MV)) and MRI parameter (wall thickness), were correlated to clinical staging of acute intestinal GvHD. Results The detection rate for acute intestinal GvHD was 56.8% for PET, 61.4% for MRI and 100% for PET-MRI. PET-MRI (median Likert-scale value: 5; range: 4–5) offers a significantly higher reliability of the diagnosis compared to PET (median: 4; range: 2–5; p = 0.01) and MRI alone (median: 4; range: 3–5; p = 0.03). The number of affected segments in PET-MRI (rs = 0.677; p s = 0.703; p < 0.001) correlated significantly with the clinical stage. SUVmax (rs = 0.345; p = 0.14), SUVpeak (rs = 0.276; p = 0.24) and wall thickening (rs = 0.174; p = 0.17) did not show a significant correlation to clinical stage. Conclusion 18F-FDG-PET-MRI allows for highly reliable assessment of acute intestinal GvHD and adds information indicating clinical severity.
ISSN:14712407
DOI:10.1186/s12885-021-08748-x