Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Moroccan Thymus capitatus Essential Oil
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| Název: | Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Moroccan Thymus capitatus Essential Oil |
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| Autoři: | Amina Amakran, Meriem Hamoudane, Fabrice Pagniez, Ahmed Lamarti, Carine Picot, Gilles Figueredo, Mohamed Nhiri, Patrice Le Pape |
| Přispěvatelé: | Abdelmalek Essaadi University Tétouan = Université Abdelmalek Essaadi Tétouan (UAE), Cibles et Médicaments des Infections et de l'Immunité - UR 1155 (IICiMed), Nantes Université - UFR des Sciences Pharmaceutiques et Biologiques (Nantes Univ - UFR Pharmacie), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Lexva Analytique |
| Zdroj: | Chemistry & Biodiversity. 21 |
| Informace o vydavateli: | Wiley, 2024. |
| Rok vydání: | 2024 |
| Témata: | MESH: Fungi, 0301 basic medicine, antioxidant, Antifungal Agents, Volatile, hemolytic, Microbial Sensitivity Tests, Antifungal, Hemolysis, Antioxidants, MESH: Thymus Plant, Thymus Plant, 03 medical and health sciences, Picrates, Oils, Volatile, Humans, MESH: Picrates, MESH: Microbial Sensitivity Tests, 0303 health sciences, MESH: Humans, MESH: Antioxidants, Biphenyl Compounds, Fungi, MESH: Antifungal Agents, beta Carotene, MESH: Hemolysis, 3. Good health, Morocco, Thymus capitatus, MESH: Oils, MESH: Morocco, MESH: beta Carotene, MESH: Biphenyl Compounds, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Popis: | This study aimed to define the chemical composition of Moroccan Thymus capitatus essential oil, and to investigate its in vitro antioxidant and antifungal activities against human pathogenic fungi. Chemical analysis using GC‐FID and GC‐MS system revealed 28 constituents, representing 99 % of total compounds. Oxygenated monoterpenes represented the highest proportion (79.79 %), among which carvacrol (75.73 %) was the predominant compound, followed by linalol (2.26 %). Monoterpene hydrocarbons represented the second major fraction (16.29 %): within them, the predominant constituents were γ‐terpinene (5,55 %), ρ‐cymene (5,50 %), and β‐caryophyllene (2.73 %). Antioxidant activity was performed by DPPH scavenging, β‐carotene bleaching inhibition, and ferric reducing power. T. capitatus revealed pronounced DPPH radical scavenging activity (IC50=110.53 μg mL−1), strong ferric reducing ability (EC50=644.4 μg mL−1), and a remarkable degree of protection against lipid peroxidation during β‐carotene bleaching inhibition (IC50=251.76 μg mL−1). Antifungal activity was carried out against Candida, Aspergillus, and Rhizopus species by microdilution method. T. capitatus exhibited potent anticandidal activity (MIC=125–500 μg mL−1) and strong inhibition against filamentous fungi (MIC=250‐500 μg mL−1). Its hemolytic activity against human erythrocytes had a low toxic effect at concentrations lower than 1250 μg mL−1. The useful antioxidant properties and broad antifungal effect of T. capitatus EO confirm its considerable potential for the food industry and for phytopharmaceutical production. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.202300563 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38880770 |
| Rights: | Wiley Online Library User Agreement |
| Přístupové číslo: | edsair.doi.dedup.....dd6365a87f55d83bc931b9a818dd1846 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | This study aimed to define the chemical composition of Moroccan Thymus capitatus essential oil, and to investigate its in vitro antioxidant and antifungal activities against human pathogenic fungi. Chemical analysis using GC‐FID and GC‐MS system revealed 28 constituents, representing 99 % of total compounds. Oxygenated monoterpenes represented the highest proportion (79.79 %), among which carvacrol (75.73 %) was the predominant compound, followed by linalol (2.26 %). Monoterpene hydrocarbons represented the second major fraction (16.29 %): within them, the predominant constituents were γ‐terpinene (5,55 %), ρ‐cymene (5,50 %), and β‐caryophyllene (2.73 %). Antioxidant activity was performed by DPPH scavenging, β‐carotene bleaching inhibition, and ferric reducing power. T. capitatus revealed pronounced DPPH radical scavenging activity (IC50=110.53 μg mL−1), strong ferric reducing ability (EC50=644.4 μg mL−1), and a remarkable degree of protection against lipid peroxidation during β‐carotene bleaching inhibition (IC50=251.76 μg mL−1). Antifungal activity was carried out against Candida, Aspergillus, and Rhizopus species by microdilution method. T. capitatus exhibited potent anticandidal activity (MIC=125–500 μg mL−1) and strong inhibition against filamentous fungi (MIC=250‐500 μg mL−1). Its hemolytic activity against human erythrocytes had a low toxic effect at concentrations lower than 1250 μg mL−1. The useful antioxidant properties and broad antifungal effect of T. capitatus EO confirm its considerable potential for the food industry and for phytopharmaceutical production. |
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| ISSN: | 16121880 16121872 |
| DOI: | 10.1002/cbdv.202300563 |