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Oscillatory DeltaC Expression in Neural Progenitors Primes the Prototype of Forebrain Development

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Title: Oscillatory DeltaC Expression in Neural Progenitors Primes the Prototype of Forebrain Development
Authors: Nian, Fang-Shin, Liao, Bo-Kai, Su, Yen-Lin, Wu, Pei-Rong, Tsai, Jin-Wu, Hou, Pei-Shan
Source: Mol Neurobiol
Publisher Information: Springer Science and Business Media LLC, 2024.
Publication Year: 2024
Subject Terms: Oscillation pattern, Receptors, Notch/metabolism, Zebrafish Proteins/metabolism, Neurogenesis, Neuroscience (miscellaneous), Forebrain development, Genetics & genetic processes, Prosencephalon/metabolism, Zebrafish/genetics, Cellular and Molecular Neuroscience, Génétique & processus génétiques, Prosencephalon, Neural Stem Cells, Zebrafish/metabolism, Zebrafish Proteins/genetics, Animals, Membrane Proteins/genetics, Notch signaling, Zebrafish, Receptors, Notch, Intracellular Signaling Peptides and Proteins, Prosencephalon/embryology, Gene Expression Regulation, Developmental, Membrane Proteins, Cell Differentiation, Zebrafish Proteins, Life sciences, Delta gene, Neurology, Sciences du vivant, Membrane Proteins/metabolism, Original Article, Neural Stem Cells/metabolism, Signal Transduction
Description: Notch signaling plays a pivotal role in regulating various developmental processes, particularly in controlling the timing of neuronal production within the developing neocortex. Central to this regulatory mechanism is the oscillatory pattern of Delta, which functions as a developmental clock modulator. Its deficiency profoundly impairs mammalian brain formation, highlighting its fundamental role in brain development. However, zebrafish carrying a mutation in the functional ortholog DeltaC (dlc) within their functional ortholog exhibit an intact forebrain structure, implying evolutionary variations in Notch signaling within the forebrain. In this study, we unveil the distinct yet analogous expression profiles of Delta and Her genes in the developing vertebrate forebrain. Specifically, for the first time, we detected the oscillatory expression of the Delta gene dlc in the developing zebrafish forebrain. Although this oscillatory pattern appeared irregular and was not pervasive among the progenitor population, attenuation of the dlc-involved Notch pathway using a γ-secretase inhibitor impaired neuronal differentiation in the developing zebrafish forebrain, revealing the indispensable role of the dlc-involved Notch pathway in regulating early zebrafish neurogenesis. Taken together, our results demonstrate the foundational prototype of dlc-involved Notch signaling in the developing zebrafish forebrains, upon which the intricate patterns of the mammalian neocortex may have been sculpted.
Document Type: Article
Other literature type
Language: English
ISSN: 1559-1182
0893-7648
DOI: 10.1007/s12035-024-04530-9
Access URL: https://pubmed.ncbi.nlm.nih.gov/39392541
Rights: CC BY
Accession Number: edsair.doi.dedup.....dd33a19dcdec714617d96eb6f1a736e5
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  Data: Oscillatory DeltaC Expression in Neural Progenitors Primes the Prototype of Forebrain Development
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  Data: <searchLink fieldCode="AR" term="%22Nian%2C+Fang-Shin%22">Nian, Fang-Shin</searchLink><br /><searchLink fieldCode="AR" term="%22Liao%2C+Bo-Kai%22">Liao, Bo-Kai</searchLink><br /><searchLink fieldCode="AR" term="%22Su%2C+Yen-Lin%22">Su, Yen-Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Wu%2C+Pei-Rong%22">Wu, Pei-Rong</searchLink><br /><searchLink fieldCode="AR" term="%22Tsai%2C+Jin-Wu%22">Tsai, Jin-Wu</searchLink><br /><searchLink fieldCode="AR" term="%22Hou%2C+Pei-Shan%22">Hou, Pei-Shan</searchLink>
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  Data: Mol Neurobiol
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– Name: Abstract
  Label: Description
  Group: Ab
  Data: Notch signaling plays a pivotal role in regulating various developmental processes, particularly in controlling the timing of neuronal production within the developing neocortex. Central to this regulatory mechanism is the oscillatory pattern of Delta, which functions as a developmental clock modulator. Its deficiency profoundly impairs mammalian brain formation, highlighting its fundamental role in brain development. However, zebrafish carrying a mutation in the functional ortholog DeltaC (dlc) within their functional ortholog exhibit an intact forebrain structure, implying evolutionary variations in Notch signaling within the forebrain. In this study, we unveil the distinct yet analogous expression profiles of Delta and Her genes in the developing vertebrate forebrain. Specifically, for the first time, we detected the oscillatory expression of the Delta gene dlc in the developing zebrafish forebrain. Although this oscillatory pattern appeared irregular and was not pervasive among the progenitor population, attenuation of the dlc-involved Notch pathway using a γ-secretase inhibitor impaired neuronal differentiation in the developing zebrafish forebrain, revealing the indispensable role of the dlc-involved Notch pathway in regulating early zebrafish neurogenesis. Taken together, our results demonstrate the foundational prototype of dlc-involved Notch signaling in the developing zebrafish forebrains, upon which the intricate patterns of the mammalian neocortex may have been sculpted.
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  Data: 10.1007/s12035-024-04530-9
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  Data: <link linkTarget="URL" linkTerm="https://pubmed.ncbi.nlm.nih.gov/39392541" linkWindow="_blank">https://pubmed.ncbi.nlm.nih.gov/39392541</link>
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        Value: 10.1007/s12035-024-04530-9
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      – Text: English
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        PageCount: 17
        StartPage: 4076
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        Type: general
      – SubjectFull: Receptors, Notch/metabolism
        Type: general
      – SubjectFull: Zebrafish Proteins/metabolism
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      – SubjectFull: Membrane Proteins/genetics
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      – SubjectFull: Notch signaling
        Type: general
      – SubjectFull: Zebrafish
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      – SubjectFull: Receptors, Notch
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      – SubjectFull: Signal Transduction
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      – TitleFull: Oscillatory DeltaC Expression in Neural Progenitors Primes the Prototype of Forebrain Development
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