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Anti-HBc IgG Levels: A Predictor of HBsAg Seroclearance in Chronic Hepatitis B Patients with Nucleos(t)ide Analogue-Induced HBeAg Seroclearance

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Title: Anti-HBc IgG Levels: A Predictor of HBsAg Seroclearance in Chronic Hepatitis B Patients with Nucleos(t)ide Analogue-Induced HBeAg Seroclearance
Authors: Saein Kim, Sunghwan Yoo, Jung Il Lee, Sora Kim, Hye Young Chang, Dokyun Kim, Seok Hoon Jeong, Kwan Sik Lee, Hyun Woong Lee
Contributors: Saein Kim, Sunghwan Yoo, Jung Il Lee, Sora Kim, Hye Young Chang, Dokyun Kim, Seok Hoon Jeong, Kwan Sik Lee, Hyun Woong Lee, Kim, Dokyun
Source: Dig Dis Sci
Publisher Information: Springer Science and Business Media LLC, 2021.
Publication Year: 2021
Subject Terms: Male, 0301 basic medicine, Hepatitis B virus, Antiviral Agents / therapeutic use, Hepatitis B Antibodies / blood, Antiviral Agents, 03 medical and health sciences, Hepatitis B, Chronic, Seroconversion / drug effects, Liver Function Tests, Liver Function Tests / methods, Humans, Serologic Tests, Hepatitis B e Antigens, Hepatitis B Antibodies, Retrospective Studies, Hepatitis B core antigen, Hepatitis B e antigen, 0303 health sciences, Hepatitis B Core Antigens / immunology, Serologic Tests / methods, Immunoglobulin G / blood, Nucleosides, Middle Aged, Hepatitis B e Antigens / immunology, Hepatitis B, Prognosis, Hepatitis B Core Antigens, 3. Good health, Treatment Outcome, Hepatitis B surface antigen, Chronic* / drug therapy, Seroconversion, Immunoglobulin G, Chronic* / immunology, Original Article, Female, Nucleosides / therapeutic use
Description: We investigated the efficiency of the indirect ratio of anti-HBc IgG at predicting HBsAg seroclearance in patients with nucleos(t)ide analogue (NA)-induced HBeAg seroclearance.We performed a retrospective study that included 366 chronic hepatitis B patients (March 2007 to December 2016) at a single tertiary hospital. These patients were HBsAg seropositive, and experienced NA-induced HBeAg seroclearance. The indirect ratio of light absorbance of anti-HBc IgG levels were measured with chemiluminescent microparticle immunoassay using the Architect Anti-HBc assay (Abbott Laboratories, IL, USA) as a qualitative method prior to antiviral therapy. We calculated the cumulative incidences of HBsAg seroclearance based on the anti-HBc IgG levels.After a 10-year follow-up, 48 patients experienced HBsAg seroclearance (13.1%). Thirty-three of 179 patients who had an indirect ratio of light absorbance of anti-HBc IgG
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1573-2568
0163-2116
DOI: 10.1007/s10620-021-06845-2
Access URL: https://link.springer.com/content/pdf/10.1007/s10620-021-06845-2.pdf
https://pubmed.ncbi.nlm.nih.gov/33517556
https://pubmed.ncbi.nlm.nih.gov/33517556/
https://link.springer.com/article/10.1007/s10620-021-06845-2
https://link.springer.com/content/pdf/10.1007/s10620-021-06845-2.pdf
https://www.ncbi.nlm.nih.gov/pubmed/33517556
https://europepmc.org/article/MED/33517556
Rights: CC BY NC
CC BY NC ND
URL: http://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) .
Accession Number: edsair.doi.dedup.....dcd9b2c845fe459b9575828609a05cd0
Database: OpenAIRE
Description
Abstract:We investigated the efficiency of the indirect ratio of anti-HBc IgG at predicting HBsAg seroclearance in patients with nucleos(t)ide analogue (NA)-induced HBeAg seroclearance.We performed a retrospective study that included 366 chronic hepatitis B patients (March 2007 to December 2016) at a single tertiary hospital. These patients were HBsAg seropositive, and experienced NA-induced HBeAg seroclearance. The indirect ratio of light absorbance of anti-HBc IgG levels were measured with chemiluminescent microparticle immunoassay using the Architect Anti-HBc assay (Abbott Laboratories, IL, USA) as a qualitative method prior to antiviral therapy. We calculated the cumulative incidences of HBsAg seroclearance based on the anti-HBc IgG levels.After a 10-year follow-up, 48 patients experienced HBsAg seroclearance (13.1%). Thirty-three of 179 patients who had an indirect ratio of light absorbance of anti-HBc IgG
ISSN:15732568
01632116
DOI:10.1007/s10620-021-06845-2