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Stem cell homing as a promising strategy for bone regeneration: focus on biomaterials

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Název: Stem cell homing as a promising strategy for bone regeneration: focus on biomaterials
Autoři: SB Liu, Y Liu, ZZ Zheng, BL Li, JJ Shao, X Liu, E Luo, HH Liu
Zdroj: European Cells & Materials, Vol 51, Pp 83-102 (2025)
Informace o vydavateli: Forum Multimedia Publishing LLC, 2025.
Rok vydání: 2025
Témata: bioactive factors, Orthopedic surgery, stem cell homing, bone regeneration, RC925-935, Diseases of the musculoskeletal system, bone tissue engineering, RD701-811, biomaterials
Popis: Bone regeneration, predominantly orchestrated via stem cell, holds significant implications for orthopedic and reconstructive surgery. Owing to the inherent limitations associated with stem cell transplantation and related modalities, the strategy of biomaterial-mediated endogenous stem cell homing has emerged as a promising alternative, which has garnered substantial interest from both the academic and clinical communities. This innovative approach employs chemokines and other molecular cues to direct the recruitment of endogenous stem cells to the site of bone defect, thereby promoting bone regeneration in a more physiologically relevant manner. Bone marrow is recognized as the primary niche and a major reservoir for a diverse array of stem cells. In this comprehensive review, we meticulously delineate the endogenous stem cell homing paradigm and describe the biological factors affecting stem cell homing. Moreover, we provide an in-depth analysis of the latest developments in functionally enriched biomaterials that are specifically designed to facilitate the homing, survival, and functional integration of stem cell at the site of bone injury.
Druh dokumentu: Article
Jazyk: English
ISSN: 1473-2262
DOI: 10.22203/ecm.v051a05
Přístupová URL adresa: https://doaj.org/article/8199925d168447729a4597ae6c52c3af
Přístupové číslo: edsair.doi.dedup.....dcd4219c294b98aaf6eeb29550f49034
Databáze: OpenAIRE
Popis
Abstrakt:Bone regeneration, predominantly orchestrated via stem cell, holds significant implications for orthopedic and reconstructive surgery. Owing to the inherent limitations associated with stem cell transplantation and related modalities, the strategy of biomaterial-mediated endogenous stem cell homing has emerged as a promising alternative, which has garnered substantial interest from both the academic and clinical communities. This innovative approach employs chemokines and other molecular cues to direct the recruitment of endogenous stem cells to the site of bone defect, thereby promoting bone regeneration in a more physiologically relevant manner. Bone marrow is recognized as the primary niche and a major reservoir for a diverse array of stem cells. In this comprehensive review, we meticulously delineate the endogenous stem cell homing paradigm and describe the biological factors affecting stem cell homing. Moreover, we provide an in-depth analysis of the latest developments in functionally enriched biomaterials that are specifically designed to facilitate the homing, survival, and functional integration of stem cell at the site of bone injury.
ISSN:14732262
DOI:10.22203/ecm.v051a05