Synaptic protein CSF levels relate to memory scores in individuals without dementia
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| Názov: | Synaptic protein CSF levels relate to memory scores in individuals without dementia |
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| Autori: | Kirsten E. J. Wesenhagen, Diederick M. de Leeuw, Jori Tomassen, Johan Gobom, Isabelle Bos, Stephanie J. B. Vos, Pablo Martinez-Lage, Mikel Tainta, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Rik Vandenberghe, Yvonne Freund-Levi, Frans Verhey, Simon Lovestone, Johannes Streffer, Valerija Dobricic, Kaj Blennow, Philip Scheltens, August B. Smit, Lars Bertram, Charlotte E. Teunissen, Henrik Zetterberg, Betty M. Tijms, Pieter Jelle Visser, the Alzheimer’s Disease Neuroimaging Initiative |
| Prispievatelia: | Alzheimer's Disease Neuroimaging Initiative, Alzheimer’s Disease Neuroimaging Initiative |
| Zdroj: | Alzheimers Res Ther Res Sq Alzheimer’s Research & Therapy, Vol 17, Iss 1, Pp 1-15 (2025) Alzheimer's research & therapy, vol. 17, no. 1, pp. 56 Alzheimer's research & therapy Alzheimer's Research & Therapy |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2024. |
| Rok vydania: | 2024 |
| Predmety: | Male, MILD COGNITIVE IMPAIRMENT, Early Alzheimer's disease, PROGRESSION, Neurosciences. Biological psychiatry. Neuropsychiatry, early Alzheimer's disease, Neuropsychological Tests, ASTROCYTES, Article, Synaptic proteins, OLIGOMERS, Alzheimer Disease, Memory, Humans, Cognitive Dysfunction, RC346-429, memory performance, Aged, Aged, 80 and over, cerebrospinal fluid proteomics, DECLINE, Memory Disorders, Amyloid beta-Peptides, Research, ASSOCIATION, Cerebrospinal fluid proteomics, Middle Aged, AMYLOID-BETA, NEUROGRANIN, ALZHEIMERS-DISEASE, Memory performance, Female, Human medicine, Neurology. Diseases of the nervous system, TAU, Cognitive Dysfunction/cerebrospinal fluid, Cognitive Dysfunction/psychology, Biomarkers/cerebrospinal fluid, Alzheimer Disease/cerebrospinal fluid, Memory Disorders/cerebrospinal fluid, Memory Disorders/etiology, Memory/physiology, Synapses, Biomarkers, RC321-571 |
| Popis: | Background We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations. Methods We included 242 CN (105(43%) abnormal amyloid), and 278 MCI individuals (183(66%) abnormal amyloid) from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). For 181 (EMIF-AD MBD) and 36 (ADNI) proteins with a synaptic annotation in SynGO, associations with word learning recall were analysed with linear models. Results Subsets of synaptic proteins showed lower levels with worse recall in preclinical AD (EMIF-AD MBD: 7, ADNI: 5 proteins, none overlapping), prodromal AD (EMIF-AD MBD only, 27 proteins) and non-AD MCI (EMIF-AD MBD: 1, ADNI: 7 proteins). The majority of these associations were specific to these clinical groups. Conclusions Synaptic disturbance-related memory impairment occurred very early in AD, indicating it may be relevant to develop therapies targeting the synapse early in the disease. |
| Druh dokumentu: | Article Other literature type Research |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1758-9193 |
| DOI: | 10.1186/s13195-025-01703-z |
| DOI: | 10.21203/rs.3.rs-4607202/v1 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39108495 https://pubmed.ncbi.nlm.nih.gov/40033427 https://doaj.org/article/47b19da867c743579995709d704bfaee https://hdl.handle.net/1871.1/b6ecb675-6d39-4a1a-a1e9-391d02422021 https://doi.org/10.1186/s13195-025-01703-z https://research.vu.nl/en/publications/b6ecb675-6d39-4a1a-a1e9-391d02422021 https://pure.amsterdamumc.nl/en/publications/87c6ac52-cbdf-47ac-a371-10530f1fa492 https://doi.org/10.1186/s13195-025-01703-z https://ora.ox.ac.uk/objects/uuid:c2768b46-6c36-496f-a139-d992405922a6 https://doi.org/10.1186/s13195-025-01703-z https://serval.unil.ch/resource/serval:BIB_FFC5500F5D01.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_FFC5500F5D015 https://serval.unil.ch/notice/serval:BIB_FFC5500F5D01 https://hdl.handle.net/10067/2133240151162165141 https://repository.uantwerpen.be/docstore/d:irua:28131 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....dc33d5d881629cd8a81df700e90d8cb9 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Background We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations. Methods We included 242 CN (105(43%) abnormal amyloid), and 278 MCI individuals (183(66%) abnormal amyloid) from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery (EMIF-AD MBD) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). For 181 (EMIF-AD MBD) and 36 (ADNI) proteins with a synaptic annotation in SynGO, associations with word learning recall were analysed with linear models. Results Subsets of synaptic proteins showed lower levels with worse recall in preclinical AD (EMIF-AD MBD: 7, ADNI: 5 proteins, none overlapping), prodromal AD (EMIF-AD MBD only, 27 proteins) and non-AD MCI (EMIF-AD MBD: 1, ADNI: 7 proteins). The majority of these associations were specific to these clinical groups. Conclusions Synaptic disturbance-related memory impairment occurred very early in AD, indicating it may be relevant to develop therapies targeting the synapse early in the disease. |
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| ISSN: | 17589193 |
| DOI: | 10.1186/s13195-025-01703-z |