Brain Function in the Vegetative State
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| Title: | Brain Function in the Vegetative State |
|---|---|
| Authors: | Laureys, Steven, Antoine, S., Boly, Mélanie, Elincx, S., Faymonville, Marie-Elisabeth, Berré, Jacques, Sadzot, Bernard, Ferring, Martine, De Tiège, Xavier, van Bogaert, Patrick, Hansen, Isabelle, Damas, Pierre, Mavroudakis, Nicolas, Lambermont, Bernard, Del Fiore, Guy, Aerts, Joël, Degueldre, Christian, Phillips, Christophe, Franck, Georges, Vincent, Jean-Louis, Lamy, Maurice, Luxen, André, Moonen, Gustave, Goldman, Serge, Maquet, Pierre |
| Source: | Advances in Experimental Medicine and Biology ISBN: 9781475709766 Acta neurologica belgica, 102 (4 |
| Publisher Information: | Springer US, 2004. |
| Publication Year: | 2004 |
| Subject Terms: | 0301 basic medicine, positron emission tomography, Cerebrovascular Circulation -- physiology, consciousness, vegetative state, Functional connectivity, 0302 clinical medicine, Thalamus, Neural Pathways, Human health sciences, brain metabolism, cerebral blood flow, Tomography, Persistent Vegetative State -- pathology, Cerebral Cortex -- radionuclide imaging, Cerebral Cortex, Vegetative state, Thalamus -- radionuclide imaging, Brain -- physiopathology, Brain, Persistent Vegetative State -- radionuclide imaging, Sciences bio-médicales et agricoles, Energy Metabolism -- physiology, 3. Good health, Neurology, Consciousness -- physiology, Cerebrovascular Circulation, Recovery of Function -- physiology, Tomography, Emission-Computed, Positron emission tomography, Consciousness, Persistent Vegetative State -- physiopathology, Thalamus -- pathology, functional neuroimaging, Sciences de la santé humaine, 03 medical and health sciences, Neural Pathways -- pathology, Neurologie, Cerebral Cortex -- physiopathology, Humans, Wakefulness -- physiology, Functional neuroimaging, Thalamus -- physiopathology, Wakefulness, Neural Pathways -- radionuclide imaging, Brain metabolism cerebral blood flow, Brain plasticity, Neural Pathways -- physiopathology, Persistent Vegetative State, functional connectivity, Recovery of Function, Cerebral Cortex -- pathology, Psychologie, Emission-Computed, Energy Metabolism, brain plasticity |
| Description: | Positron emission tomography (PET) techniques represent a useful tool to better understand the residual brain function in vegetative state patients. It has been shown that overall cerebral metabolic rates for glucose are massively reduced in this condition. However, the recovery of consciousness from vegetative state is not always associated with substantial changes in global metabolism. This finding led us to hypothesize that some vegetative patients are unconscious not just because of a global loss of neuronal function, but rather due to an altered activity in some critical brain regions and to the abolished functional connections between them. We used voxel-based Statistical Parametric Mapping (SPM) approaches to characterize the functional neuroanatomy of the vegetative state. The most dysfunctional brain regions were bilateral frontal and parieto-temporal associative cortices. Despite the metabolic impairment, external stimulation still induced a significant neuronal activation (i.e., change in blood flow) in vegetative patients as shown by both auditory click stimuli and noxious somatosensory stimuli. However, this activation was limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception. Finally, we demonstrated that vegetative patients have impaired functional connections between distant cortical areas and between the thalami and the cortex and, more importantly, that recovery of consciousness is paralleled by a restoration of this cortico-thalamo-cortical interaction. |
| Document Type: | Part of book or chapter of book Article |
| File Description: | 1 full-text file(s): application/pdf; No full-text files |
| DOI: | 10.1007/978-0-306-48526-8_21 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/12534245 https://pubmed.ncbi.nlm.nih.gov/15053441 https://link.springer.com/chapter/10.1007/978-0-306-48526-8_21 https://pubmed.ncbi.nlm.nih.gov/12534245/ https://link.springer.com/10.1007/978-0-306-48526-8_21 https://www.ncbi.nlm.nih.gov/pubmed/12534245 http://www.coma.ulg.ac.be/papers/vs/VS_ANB2002.pdf https://rd.springer.com/chapter/10.1007/978-0-306-48526-8_21 https://hdl.handle.net/2268/908 https://hdl.handle.net/2268/110960 http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51284 |
| Accession Number: | edsair.doi.dedup.....d8ca8708eaabe7789896e080fd91b11f |
| Database: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Positron emission tomography (PET) techniques represent a useful tool to better understand the residual brain function in vegetative state patients. It has been shown that overall cerebral metabolic rates for glucose are massively reduced in this condition. However, the recovery of consciousness from vegetative state is not always associated with substantial changes in global metabolism. This finding led us to hypothesize that some vegetative patients are unconscious not just because of a global loss of neuronal function, but rather due to an altered activity in some critical brain regions and to the abolished functional connections between them. We used voxel-based Statistical Parametric Mapping (SPM) approaches to characterize the functional neuroanatomy of the vegetative state. The most dysfunctional brain regions were bilateral frontal and parieto-temporal associative cortices. Despite the metabolic impairment, external stimulation still induced a significant neuronal activation (i.e., change in blood flow) in vegetative patients as shown by both auditory click stimuli and noxious somatosensory stimuli. However, this activation was limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception. Finally, we demonstrated that vegetative patients have impaired functional connections between distant cortical areas and between the thalami and the cortex and, more importantly, that recovery of consciousness is paralleled by a restoration of this cortico-thalamo-cortical interaction. |
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| DOI: | 10.1007/978-0-306-48526-8_21 |