Protective effects of hemin and tetrakis(4-benzoic acid)porphyrin on bacterial mutagenesis and mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene
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| Titel: | Protective effects of hemin and tetrakis(4-benzoic acid)porphyrin on bacterial mutagenesis and mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene |
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| Autoren: | Kwang Kyun Park, Won Young Lee, Jong Min Lee, Won Yoon Chung, Young-Joon Surh |
| Weitere Verfasser: | Won-Yoon Chung, Jong-Min Lee, Won-Young Lee, Young-Joon Surh, Kwang-Kyun Park, Park, Kwang Kyun |
| Quelle: | Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 472:139-145 |
| Verlagsinformationen: | Elsevier BV, 2000. |
| Publikationsjahr: | 2000 |
| Schlagwörter: | Salmonella typhimurium, 0301 basic medicine, Free Radical Scavengers/pharmacology, Hemin/pharmacology, Skin/pathology, Porphyrins, Skin Neoplasms, Anticarcinogenic Agents/pharmacology, Metalloporphyrins, 9,10-Dimethyl-1,2-benzanthracene, Metalloporphyrins/pharmacology, Salmonella typhimurium/drug effects, DNA Adducts/analysis, DNA Adducts, Mice, 03 medical and health sciences, Animals, Anticarcinogenic Agents, Humans, Skin, Mice, Inbred ICR, 0303 health sciences, 9,10-Dimethyl-1,2-benzanthracene/pharmacokinetics, Mutagenicity Tests, Mouse skin carcinogenesis, Skin Neoplasms/prevention & control, Chlorophyllin, Antimutagenic Agents, Free Radical Scavengers, Skin Neoplasms/chemically induced, Inbred ICR, Tetrakis(4-benzoic acid)porphyrin, 3. Good health, Photochemotherapy, Skin/drug effects, Antimutagenic Agents/pharmacology, Antimutagenicity, Hemin, Female |
| Beschreibung: | Porphyrins which are widespread in nature can interfere with the actions of certain carcinogens and mutagens, and have also been used clinically in photodynamic therapy (PDT) of tumors. Porphyrins such as chlorophyll, chlorophyllin (CHL) and hemin are known to inactivate various mutagens by forming complexes with them. Tetrakis(4-benzoic acid)porphyrin (TBAP) has been developed as a photosensitizer for PDT and its metal complex, MnTBAP has been shown to be efficacious in a variety of in vitro and in vivo oxidative stress models of human diseases. In the present study, we have found that TBAP and hemin exert concentration-related inhibition of his(+) reversion in Salmonella typhimurium TA100 induced by 7, 12-dimethylbenz[a]anthracene (DMBA), and significantly reduced both incidence and multiplicity of skin tumors when topically applied prior to treatment of 12-O-tetradecanoylphorbol-13-acetate in female ICR mice. Covalent DNA binding of DMBA in mouse skin was also significantly inhibited by topical application of TBAP or hemin as well as CHL. These results suggest the chemopreventive potential of compounds containing a porphyrin nucleus. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 1383-5718 |
| DOI: | 10.1016/s1383-5718(00)00137-6 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/11113706 https://www.sciencedirect.com/science/article/pii/S1383571800001376 https://yonsei.pure.elsevier.com/en/publications/protective-effects-of-hemin-and-tetrakis4-benzoic-acidporphyrin-o https://pubmed.ncbi.nlm.nih.gov/11113706/ https://ir.ymlib.yonsei.ac.kr/handle/22282913/171808 https://mdanderson.elsevierpure.com/en/publications/protective-effects-of-hemin-and-tetrakis4-benzoic-acidporphyrin-o https://www.ncbi.nlm.nih.gov/pubmed/11113706 |
| Rights: | Elsevier TDM CC BY NC ND |
| Dokumentencode: | edsair.doi.dedup.....d8828c97fe63376ba00bfce9b64c69f8 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Porphyrins which are widespread in nature can interfere with the actions of certain carcinogens and mutagens, and have also been used clinically in photodynamic therapy (PDT) of tumors. Porphyrins such as chlorophyll, chlorophyllin (CHL) and hemin are known to inactivate various mutagens by forming complexes with them. Tetrakis(4-benzoic acid)porphyrin (TBAP) has been developed as a photosensitizer for PDT and its metal complex, MnTBAP has been shown to be efficacious in a variety of in vitro and in vivo oxidative stress models of human diseases. In the present study, we have found that TBAP and hemin exert concentration-related inhibition of his(+) reversion in Salmonella typhimurium TA100 induced by 7, 12-dimethylbenz[a]anthracene (DMBA), and significantly reduced both incidence and multiplicity of skin tumors when topically applied prior to treatment of 12-O-tetradecanoylphorbol-13-acetate in female ICR mice. Covalent DNA binding of DMBA in mouse skin was also significantly inhibited by topical application of TBAP or hemin as well as CHL. These results suggest the chemopreventive potential of compounds containing a porphyrin nucleus. |
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| ISSN: | 13835718 |
| DOI: | 10.1016/s1383-5718(00)00137-6 |