Oxytocin response to an experimental psychosocial challenge in adults exposed to traumatic experiences during childhood or adolescence
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| Názov: | Oxytocin response to an experimental psychosocial challenge in adults exposed to traumatic experiences during childhood or adolescence |
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| Autori: | Pierrehumbert, B., Torrisi, R., Laufer, D., Halfon, O., Ansermet, François, Beck Popovic, M. |
| Zdroj: | Neuroscience, Vol. 166, No 1 (2010) pp. 168-177 |
| Informácie o vydavateľovi: | Elsevier BV, 2010. |
| Rok vydania: | 2010 |
| Predmety: | Neoplasms/psychology, Adult, Male, Aging, Hypothalamo-Hypophyseal System, Adolescent, Hydrocortisone, Neuropsychological Tests, Oxytocin, Time, Stress Disorders, Post-Traumatic, ddc:616.89, Hydrocortisone/blood/secretion, Young Adult, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Stress, Psychological/etiology/*metabolism/physiopathology, Neoplasms, Humans, Psychology, Stress Disorders, Post-Traumatic/etiology/*metabolism/physiopathology, Child, Sex Characteristics, Mood Disorders, Acute Disease/psychology, Hypothalamo-Hypophyseal System/*metabolism/physiopathology/secretion, Child Abuse, Sexual, Middle Aged, Aging/physiology/*psychology, Oxytocin/*metabolism/secretion, 3. Good health, Child Abuse, Sexual/psychology, 616.89, Mood Disorders/etiology/metabolism/physiopathology, Acute Disease, Female |
| Popis: | Long-term implications of the exposure to traumatizing experiences during childhood or adolescence, such as sexual abuse, or cancer, have been documented, namely the subjects' response to an acute stress in adulthood. Several indicators of the stress response have been considered (e.g. cortisol, heart rate). Oxytocin (OT) response to an acute stress of individuals exposed to trauma has not been documented. Eighty subjects (n=26 women who had experienced episodes of child abuse, n=25 men and women healthy survivors of cancer in childhood or adolescence, and 29 controls) have been submitted to a laboratory session involving an experimental stress challenge, the Trier social stress test. Overall, there was a clear OT response to the psychosocial challenge. Subjects having experienced a childhood/adolescence life-threatening illness had higher mean levels of OT than both abused and control subjects. There was a moderate negative relationship between OT and salivary cortisol. It is suggested that an acute stress stimulates OT secretion, and that the exposure to enduring life-threatening experiences in childhood/adolescence has long-lasting consequences regarding the stress system and connected functions, namely the activation of OT secretion. Better knowledge of such long-term implications is important so that to prevent dysregulations of the stress responses, which have been shown to be associated to the individual's mental health. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2009.12.016 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/20018229 https://archive-ouverte.unige.ch/unige:21213 http://www.sciencedirect.com/science/article/pii/S0306452209020491 https://core.ac.uk/display/60831319 https://www.sciencedirect.com/science/article/pii/S0306452209020491 https://www.ncbi.nlm.nih.gov/pubmed/20018229 https://archive-ouverte.unige.ch/unige:21213 |
| Rights: | Elsevier TDM |
| Prístupové číslo: | edsair.doi.dedup.....d87ff2652c764f92e7f1c7493c10a010 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Long-term implications of the exposure to traumatizing experiences during childhood or adolescence, such as sexual abuse, or cancer, have been documented, namely the subjects' response to an acute stress in adulthood. Several indicators of the stress response have been considered (e.g. cortisol, heart rate). Oxytocin (OT) response to an acute stress of individuals exposed to trauma has not been documented. Eighty subjects (n=26 women who had experienced episodes of child abuse, n=25 men and women healthy survivors of cancer in childhood or adolescence, and 29 controls) have been submitted to a laboratory session involving an experimental stress challenge, the Trier social stress test. Overall, there was a clear OT response to the psychosocial challenge. Subjects having experienced a childhood/adolescence life-threatening illness had higher mean levels of OT than both abused and control subjects. There was a moderate negative relationship between OT and salivary cortisol. It is suggested that an acute stress stimulates OT secretion, and that the exposure to enduring life-threatening experiences in childhood/adolescence has long-lasting consequences regarding the stress system and connected functions, namely the activation of OT secretion. Better knowledge of such long-term implications is important so that to prevent dysregulations of the stress responses, which have been shown to be associated to the individual's mental health. |
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| ISSN: | 03064522 |
| DOI: | 10.1016/j.neuroscience.2009.12.016 |