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CT-based comparison of porcine, ovine, and human pulmonary arterial morphometry

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Bibliographic Details
Title: CT-based comparison of porcine, ovine, and human pulmonary arterial morphometry
Authors: Goubergrits, Leonid, Schafstedde, Marie, Cesarovic, Nikola, Szengel, Angelika, Schmitt, Boris, Wiegand, Moritz, Romberg, Jan, Arndt, Andreas, Kuehne, Titus, Brüning, Jan
Source: Sci Rep
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Scientific Reports, 13 (1)
Scientific reports
Publisher Information: Springer Science and Business Media LLC, 2023.
Publication Year: 2023
Subject Terms: Sheep, Medizin und Gesundheit, Swine, Pulmonary Artery* / diagnostic imaging, Science, Sus scrofa, Cardiology, Hypertrophy, Pulmonary Artery, Anatomy, Computational biology and bioinformatics, Article, Pulmonary Artery* / anatomy & histology, Medicine, Humans, Animals, Tomography, X-Ray Computed, Retrospective Studies
Description: To facilitate pre-clinical animal and in-silico clinical trials for implantable pulmonary artery pressure sensors, understanding the respective species pulmonary arteries (PA) anatomy is important. Thus, morphological parameters describing PA of pigs and sheep, which are common animal models, were compared with humans. Retrospective computed tomography data of 41 domestic pigs (82.6 ± 18.8 kg), 14 sheep (49.1 ± 6.9 kg), and 49 patients (76.8 ± 18.2 kg) were used for reconstruction of the subject-specific PA anatomy. 3D surface geometries including main, left, and right PA as well as LPA and RPA side branches were manually reconstructed. Then, specific geometric parameters (length, diameters, taper, bifurcation angle, curvature, and cross-section enlargement) affecting device implantation and post-interventional device effect and efficacy were automatically calculated. For both animal models, significant differences to the human anatomy for most geometric parameters were found, even though the respective parameters’ distributions also featured relevant overlap. Out of the two animal models, sheep seem to be better suitable for a preclinical study when considering only PA morphology. Reconstructed geometries are provided as open data for future studies. These findings support planning of preclinical studies and will help to evaluate the results of animal trials.
Document Type: Article
Other literature type
File Description: application/application/pdf
Language: English
ISSN: 2045-2322
DOI: 10.1038/s41598-023-47532-8
DOI: 10.3929/ethz-b-000643744
DOI: 10.17169/refubium-49099
Access URL: https://pubmed.ncbi.nlm.nih.gov/37980386
https://doaj.org/article/1648e1c5155c4053aa0a9af7c7f86af6
http://hdl.handle.net/20.500.11850/643744
Rights: CC BY
Accession Number: edsair.doi.dedup.....d7b0c7ce260b6285199312d611f7fddd
Database: OpenAIRE
Description
Abstract:To facilitate pre-clinical animal and in-silico clinical trials for implantable pulmonary artery pressure sensors, understanding the respective species pulmonary arteries (PA) anatomy is important. Thus, morphological parameters describing PA of pigs and sheep, which are common animal models, were compared with humans. Retrospective computed tomography data of 41 domestic pigs (82.6 ± 18.8 kg), 14 sheep (49.1 ± 6.9 kg), and 49 patients (76.8 ± 18.2 kg) were used for reconstruction of the subject-specific PA anatomy. 3D surface geometries including main, left, and right PA as well as LPA and RPA side branches were manually reconstructed. Then, specific geometric parameters (length, diameters, taper, bifurcation angle, curvature, and cross-section enlargement) affecting device implantation and post-interventional device effect and efficacy were automatically calculated. For both animal models, significant differences to the human anatomy for most geometric parameters were found, even though the respective parameters’ distributions also featured relevant overlap. Out of the two animal models, sheep seem to be better suitable for a preclinical study when considering only PA morphology. Reconstructed geometries are provided as open data for future studies. These findings support planning of preclinical studies and will help to evaluate the results of animal trials.
ISSN:20452322
DOI:10.1038/s41598-023-47532-8