Noninvasive modulation of the hippocampal-entorhinal complex during spatial navigation in humans
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| Název: | Noninvasive modulation of the hippocampal-entorhinal complex during spatial navigation in humans |
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| Autoři: | Elena Beanato, Hyuk-June Moon, Fabienne Windel, Pierre Vassiliadis, Maximillian J. Wessel, Traian Popa, Menoud Pauline, Esra Neufeld, Emanuela De Falco, Baptiste Gauthier, Melanie Steiner, Olaf Blanke, Friedhelm C. Hummel |
| Zdroj: | Sci Adv Science advances, vol. 10, no. 44, pp. eado4103 |
| Informace o vydavateli: | American Association for the Advancement of Science (AAAS), 2024. |
| Rok vydání: | 2024 |
| Témata: | Male, Adult, Young Adult, Brain Mapping, Virtual Reality, Humans, Entorhinal Cortex, Female, Spatial Navigation/physiology, Hippocampus/physiology, Magnetic Resonance Imaging/methods, Entorhinal Cortex/physiology, Brain Mapping/methods, Hippocampus, Magnetic Resonance Imaging, Neuroscience, Spatial Navigation |
| Popis: | Because of the depth of the hippocampal-entorhinal complex (HC-EC) in the brain, understanding of its role in spatial navigation via neuromodulation was limited in humans. Here, we aimed to better elucidate this relationship in healthy volunteers, using transcranial temporal interference electric stimulation (tTIS), a noninvasive technique allowing to selectively neuromodulate deep brain structures. We applied tTIS to the right HC-EC in either continuous or intermittent theta-burst stimulation patterns (cTBS or iTBS), compared to a control condition, during a virtual reality–based spatial navigation task and concomitant functional magnetic resonance imaging. iTBS improved spatial navigation performance, correlated with hippocampal activity modulation, and decreased grid cell–like activity in EC. Collectively, these data provide the evidence that human HC-EC activity can be directly and noninvasively modulated leading to changes of spatial navigation behavior. These findings suggest promising perspectives for patients suffering from cognitive impairment such as following traumatic brain injury or dementia. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.ado4103 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39475597 http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_02EDFD92DD135 https://serval.unil.ch/resource/serval:BIB_02EDFD92DD13.P001/REF.pdf https://serval.unil.ch/notice/serval:BIB_02EDFD92DD13 |
| Rights: | CC BY NC URL: http://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
| Přístupové číslo: | edsair.doi.dedup.....d6941cfcbcef97d332a5172680f9553c |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Because of the depth of the hippocampal-entorhinal complex (HC-EC) in the brain, understanding of its role in spatial navigation via neuromodulation was limited in humans. Here, we aimed to better elucidate this relationship in healthy volunteers, using transcranial temporal interference electric stimulation (tTIS), a noninvasive technique allowing to selectively neuromodulate deep brain structures. We applied tTIS to the right HC-EC in either continuous or intermittent theta-burst stimulation patterns (cTBS or iTBS), compared to a control condition, during a virtual reality–based spatial navigation task and concomitant functional magnetic resonance imaging. iTBS improved spatial navigation performance, correlated with hippocampal activity modulation, and decreased grid cell–like activity in EC. Collectively, these data provide the evidence that human HC-EC activity can be directly and noninvasively modulated leading to changes of spatial navigation behavior. These findings suggest promising perspectives for patients suffering from cognitive impairment such as following traumatic brain injury or dementia. |
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| ISSN: | 23752548 |
| DOI: | 10.1126/sciadv.ado4103 |