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Nalmefene attenuates neural alcohol cue-reactivity in the ventral striatum and subjective alcohol craving in patients with alcohol use disorder

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Název: Nalmefene attenuates neural alcohol cue-reactivity in the ventral striatum and subjective alcohol craving in patients with alcohol use disorder
Autoři: Damian Karl, J. Malte Bumb, Patrick Bach, Christina Dinter, Anne Koopmann, Derik Hermann, Karl Mann, Falk Kiefer, Sabine Vollstädt-Klein
Zdroj: Psychopharmacology (Berl)
Informace o vydavateli: Springer Science and Business Media LLC, 2021.
Rok vydání: 2021
Témata: Adult, Male, Cross-Over Studies, Narcotic Antagonists, Middle Aged, 16. Peace & justice, Magnetic Resonance Imaging, Naltrexone, Double-Blind Method [MeSH], Narcotic Antagonists/pharmacology [MeSH], Striatum, Photic Stimulation/methods [MeSH], Alcoholism/psychology [MeSH], Naltrexone/analogs, Reduced drinking, Original Investigation, Narcotic Antagonists/therapeutic use [MeSH], Male [MeSH], Alcoholism/drug therapy [MeSH], Controlled drinking, Pharmacotherapy, Female [MeSH], Ventral Striatum/diagnostic imaging [MeSH], Adult [MeSH], Craving/drug effects [MeSH], Humans [MeSH], Prospective Studies [MeSH], Craving/physiology [MeSH], Middle Aged [MeSH], Naltrexone/therapeutic use [MeSH], Harm reduction, Naltrexone/pharmacology [MeSH], Ventral Striatum/physiology [MeSH], Ventral Striatum/drug effects [MeSH], Alcohol cue-reactivity, Cross-Over Studies [MeSH], Young Adult [MeSH], Cues [MeSH], Alcoholism/diagnostic imaging [MeSH], Opioid receptors, Magnetic Resonance Imaging/methods [MeSH], 3. Good health, Alcoholism, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Ventral Striatum, Humans, Female, Prospective Studies, Cues, Photic Stimulation, Craving
Popis: Rationale Alcohol use disorder is a common and devastating mental illness for which satisfactory treatments are still lacking. Nalmefene, as an opioid receptor modulator, could pharmacologically support the reduction of drinking by reducing the (anticipated) rewarding effects of alcohol and expanding the range of treatment options. It has been hypothesized that nalmefene acts via an indirect modulation of the mesolimbic reward system. So far, only a few imaging findings on the neuronal response to nalmefene are available. Objectives We tested the effect of a single dose of 18 mg nalmefene on neuronal cue-reactivity in the ventral and dorsal striatum and subjective craving. Methods Eighteen non-treatment-seeking participants with alcohol use disorder (67% male, M = 50.3 ± 13.9 years) with a current high-risk drinking level (M = 76.9 ± 52 g of pure alcohol per day) were investigated using a cue-reactivity task during functional magnetic resonance imaging (fMRI) in a double-blind, placebo-controlled, cross-over study/design. In addition, self-reported craving was assessed before and after exposure to alcohol cues. Results An a priori defined region of interest (ROI) analysis of fMRI data from 15 participants revealed that nalmefene reduced alcohol cue-reactivity in the ventral, but not the dorsal striatum. Additionally, the subjective craving was significantly reduced after the cue-reactivity task under nalmefene compared to placebo. Conclusion In the present study, reduced craving and cue-reactivity to alcohol stimuli in the ventral striatum by nalmefene indicates a potential anti-craving effect of this drug via attenuation of neural alcohol cue-reactivity.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1432-2072
0033-3158
DOI: 10.1007/s00213-021-05842-7
Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00213-021-05842-7.pdf
https://pubmed.ncbi.nlm.nih.gov/33846866
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292278/
https://link.springer.com/article/10.1007/s00213-021-05842-7
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292278/
https://link.springer.com/content/pdf/10.1007/s00213-021-05842-7.pdf
https://europepmc.org/article/MED/33846866
https://pubmed.ncbi.nlm.nih.gov/33846866/
https://repository.publisso.de/resource/frl:6447973
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....d65555df86af004ddb77d546a4ec8f3c
Databáze: OpenAIRE
Popis
Abstrakt:Rationale Alcohol use disorder is a common and devastating mental illness for which satisfactory treatments are still lacking. Nalmefene, as an opioid receptor modulator, could pharmacologically support the reduction of drinking by reducing the (anticipated) rewarding effects of alcohol and expanding the range of treatment options. It has been hypothesized that nalmefene acts via an indirect modulation of the mesolimbic reward system. So far, only a few imaging findings on the neuronal response to nalmefene are available. Objectives We tested the effect of a single dose of 18 mg nalmefene on neuronal cue-reactivity in the ventral and dorsal striatum and subjective craving. Methods Eighteen non-treatment-seeking participants with alcohol use disorder (67% male, M = 50.3 ± 13.9 years) with a current high-risk drinking level (M = 76.9 ± 52 g of pure alcohol per day) were investigated using a cue-reactivity task during functional magnetic resonance imaging (fMRI) in a double-blind, placebo-controlled, cross-over study/design. In addition, self-reported craving was assessed before and after exposure to alcohol cues. Results An a priori defined region of interest (ROI) analysis of fMRI data from 15 participants revealed that nalmefene reduced alcohol cue-reactivity in the ventral, but not the dorsal striatum. Additionally, the subjective craving was significantly reduced after the cue-reactivity task under nalmefene compared to placebo. Conclusion In the present study, reduced craving and cue-reactivity to alcohol stimuli in the ventral striatum by nalmefene indicates a potential anti-craving effect of this drug via attenuation of neural alcohol cue-reactivity.
ISSN:14322072
00333158
DOI:10.1007/s00213-021-05842-7