Cortisol and 10‐Year Cognitive Decline in Older People From the General Population
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| Názov: | Cortisol and 10‐Year Cognitive Decline in Older People From the General Population |
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| Autori: | Simone Amendola, Sami Ouanes, Leonardo Zullo, Miriam Rabl, Giorgio Pistis, Enrique Castelao, Pedro Marques‐Vidal, Julien Vaucher, Armin von Gunten, Martin Preisig, Julius Popp |
| Zdroj: | Eur J Neurol European journal of neurology, vol. 32, no. 3, pp. e70056 |
| Informácie o vydavateľovi: | Wiley, 2025. |
| Rok vydania: | 2025 |
| Predmety: | Male, Aged, 80 and over, Humans, Hydrocortisone/metabolism, Female, Aged, Saliva/metabolism, Saliva/chemistry, Cognitive Dysfunction/metabolism, Cognitive Dysfunction/genetics, Apolipoprotein E4/genetics, Prospective Studies, Neuropsychological Tests, CoLaus|PsyCoLaus, HPA axis, cognition, cognitive decline, cortisol, dementia, Hydrocortisone, Apolipoprotein E4, Original Article, Cognitive Dysfunction, Saliva |
| Popis: | ObjectiveThe present study examined bidirectional effects between salivary cortisol and cognitive functioning over time. Furthermore, the role of the APOE‐ɛ4 allele as a moderator of the associations was investigated.MethodsUsing a prospective population‐based study, we analyzed data from 752 older adults followed up over 10 years. A random‐intercept Cross‐Lagged Panel Model was applied to each combination of one cortisol measure (at waking time, 30 min after waking, 11 am, 8 pm, cortisol awakening response, total daily output, and diurnal slope) and one cognitive measure (primary outcome: Clinical Dementia Rating Scale sum of boxes score, CDR‐SB; secondary outcome: Mini‐Mental State Examination) resulting in 14 (7 × 2) models.ResultsBetween‐person effects pointed out that a higher cortisol level at 11 am was associated with increased CDR‐SB scores, and a higher cortisol awakening response was associated with decreased CDR‐SB scores. Within‐person effects indicated that cortisol levels at 11 am and 8 pm, and total daily cortisol output were associated with subsequent lower CDR‐SB scores. The APOE‐ɛ4 allele did not moderate the relationship between cortisol and cognitive functioning.ConclusionsOur findings revealed within‐person associations between higher cortisol levels and better cognitive functioning at the subsequent follow‐up, suggesting cortisol protective effects for cognitive decline. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1468-1331 1351-5101 |
| DOI: | 10.1111/ene.70056 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/40022464 https://serval.unil.ch/notice/serval:BIB_6BA0D38C10BF https://serval.unil.ch/resource/serval:BIB_6BA0D38C10BF.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6BA0D38C10BF8 |
| Rights: | CC BY NC ND URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| Prístupové číslo: | edsair.doi.dedup.....d62a1a9e5a211dae77203d3198f7e84e |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | ObjectiveThe present study examined bidirectional effects between salivary cortisol and cognitive functioning over time. Furthermore, the role of the APOE‐ɛ4 allele as a moderator of the associations was investigated.MethodsUsing a prospective population‐based study, we analyzed data from 752 older adults followed up over 10 years. A random‐intercept Cross‐Lagged Panel Model was applied to each combination of one cortisol measure (at waking time, 30 min after waking, 11 am, 8 pm, cortisol awakening response, total daily output, and diurnal slope) and one cognitive measure (primary outcome: Clinical Dementia Rating Scale sum of boxes score, CDR‐SB; secondary outcome: Mini‐Mental State Examination) resulting in 14 (7 × 2) models.ResultsBetween‐person effects pointed out that a higher cortisol level at 11 am was associated with increased CDR‐SB scores, and a higher cortisol awakening response was associated with decreased CDR‐SB scores. Within‐person effects indicated that cortisol levels at 11 am and 8 pm, and total daily cortisol output were associated with subsequent lower CDR‐SB scores. The APOE‐ɛ4 allele did not moderate the relationship between cortisol and cognitive functioning.ConclusionsOur findings revealed within‐person associations between higher cortisol levels and better cognitive functioning at the subsequent follow‐up, suggesting cortisol protective effects for cognitive decline. |
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| ISSN: | 14681331 13515101 |
| DOI: | 10.1111/ene.70056 |