Multisensory integration, brain plasticity and optogenetics in visual rehabilitation
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| Title: | Multisensory integration, brain plasticity and optogenetics in visual rehabilitation |
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| Authors: | Martina Lucchesi, José Fernando Maya-Vetencourt, Dario Rusciano |
| Source: | Front Neurol Frontiers in Neurology, Vol 16 (2025) |
| Publisher Information: | Frontiers Media SA, 2025. |
| Publication Year: | 2025 |
| Subject Terms: | Neurology, Neurology. Diseases of the nervous system, optogenetics, RC346-429, multisensory areas, brain plasticity, visual rehabilitation, cross-modality |
| Description: | Multisensory integration enables the brain to integrate information from different sensory modalities while enhancing perception. This principle relies on phenomena of neuroplasticity (i.e., the ability of neuronal networks in the brain to adapt to changing environmental conditions) and is crucial for visual rehabilitation, particularly in hemianopia and retinal degeneration. Here we review emerging experimental approaches and their translational potential for vision recovery in visually impaired patients. Rehabilitation strategies incorporating multisensory training, optogenetics, and pharmacological interventions have demonstrated to be instrumental in restoring visual function by leveraging plasticity of inputs from different sensory modalities. Emerging technologies such as virtual reality and auditory–visual stimulation further optimize neural reorganization. Future research should focus on refining these interventions to enhance sensory compensation and recovery. Understanding the role of multisensory ganglion cells and retinal circuits may unlock new strategies for improving visual function in visually impaired individuals. |
| Document Type: | Article Other literature type |
| ISSN: | 1664-2295 |
| DOI: | 10.3389/fneur.2025.1590305 |
| Access URL: | https://doaj.org/article/01447b97595f4f73ba22e7b1f71d3232 https://hdl.handle.net/11568/1318668 https://doi.org/10.3389/fneur.2025.1590305 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....d59c69f68575f74b0ad6b48ed18126e0 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Multisensory integration enables the brain to integrate information from different sensory modalities while enhancing perception. This principle relies on phenomena of neuroplasticity (i.e., the ability of neuronal networks in the brain to adapt to changing environmental conditions) and is crucial for visual rehabilitation, particularly in hemianopia and retinal degeneration. Here we review emerging experimental approaches and their translational potential for vision recovery in visually impaired patients. Rehabilitation strategies incorporating multisensory training, optogenetics, and pharmacological interventions have demonstrated to be instrumental in restoring visual function by leveraging plasticity of inputs from different sensory modalities. Emerging technologies such as virtual reality and auditory–visual stimulation further optimize neural reorganization. Future research should focus on refining these interventions to enhance sensory compensation and recovery. Understanding the role of multisensory ganglion cells and retinal circuits may unlock new strategies for improving visual function in visually impaired individuals. |
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| ISSN: | 16642295 |
| DOI: | 10.3389/fneur.2025.1590305 |