Risk of Major Types of Dementias Following Hospital-Diagnosed Infections and Autoimmune Diseases
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| Názov: | Risk of Major Types of Dementias Following Hospital-Diagnosed Infections and Autoimmune Diseases |
|---|---|
| Autori: | Janbek, Janet, Laursen, Thomas Munk, Frimodt-Møller, Niels, Magyari, Melinda, Haas, Jürgen G., Lathe, Richard, Waldemar, Gunhild |
| Zdroj: | J Alzheimers Dis Janbek, J, Laursen, T M, Frimodt-Møller, N, Magyari, M, Haas, J G, Lathe, R & Waldemar, G 2024, ' Risk of Major Types of Dementias Following Hospital-Diagnosed Infections and Autoimmune Diseases ', Journal of Alzheimer's Disease, vol. 98, no. 4, pp. 1503-1514 . https://doi.org/10.3233/JAD-231349 Janbek, J, Laursen, T M, Frimodt-Møller, N, Magyari, M, Haas, J G, Lathe, R & Waldemar, G 2024, 'Risk of Major Types of Dementias Following Hospital-Diagnosed Infections and Autoimmune Diseases', Journal of Alzheimer's Disease, vol. 98, no. 4, pp. 1503-1514. https://doi.org/10.3233/JAD-231349 |
| Informácie o vydavateľovi: | SAGE Publications, 2024. |
| Rok vydania: | 2024 |
| Predmety: | Alzheimer Disease/diagnosis, immunosenescence, 0301 basic medicine, Dementia, Vascular, autoimmune disease, vascular dementia, infection, Hospitals, population-based, Autoimmune Diseases, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Autoimmune Diseases/epidemiology, Alzheimer Disease, Case-Control Studies, Humans, epidemiology, reverse causality, Alzheimer's disease, Research Article |
| Popis: | Background: Population-based studies have shown an increased risk of dementia after infections, but weaker links were reported for autoimmune diseases. Evidence is scarce for whether the links may be modified by the dementia or exposure subtype. Objective: We aimed to investigate the association between infections and/or autoimmune diseases and rates of major types of dementias in the short- and long terms. Methods: Nationwide nested case-control study of dementia cases (65+ years) diagnosed in Denmark 2016–2020 and dementia-free controls. Exposures were hospital-diagnosed infections and autoimmune diseases in the preceding 35 years. Two groups of dementia cases were those diagnosed in memory clinics (MC) and those diagnosed outside memory clinics (non-memory clinic cases, NMC). Results: In total, 26,738 individuals were MC and 12,534 were NMC cases. Following any infection, the incidence rate ratio (IRR) for MC cases was 1.23 (95% CI 1.20–1.27) and 1.70 for NMC cases (1.62–1.76). Long-term increased rates were seen for vascular dementia and NMC cases. IRRs for autoimmune diseases were overall statistically insignificant. Conclusions: Cases with vascular dementia and not Alzheimer’s disease, and a subgroup of cases identified with poorer health have increased long-term risk following infections. Autoimmune diseases were not associated with any type of dementia. Notably increased risks (attributed to the short term) and for NMC cases may indicate that immunosenescence rather than de novo infection explains the links. Future focus on such groups and on the role of vascular pathology will explain the infection-dementia links, especially in the long term. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-231349 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38640163 https://curis.ku.dk/ws/files/392571985/jad_2024_98_4_jad_98_4_jad231349_jad_98_jad231349.pdf https://pure.au.dk/portal/en/publications/7f019e9c-4440-4fdd-bd39-30952314bbc3 https://doi.org/10.3233/JAD-231349 http://www.scopus.com/inward/record.url?scp=85191105249&partnerID=8YFLogxK |
| Rights: | CC BY NC URL: http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Prístupové číslo: | edsair.doi.dedup.....d13cb8054b9354990db40b09ba4126bd |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Background: Population-based studies have shown an increased risk of dementia after infections, but weaker links were reported for autoimmune diseases. Evidence is scarce for whether the links may be modified by the dementia or exposure subtype. Objective: We aimed to investigate the association between infections and/or autoimmune diseases and rates of major types of dementias in the short- and long terms. Methods: Nationwide nested case-control study of dementia cases (65+ years) diagnosed in Denmark 2016–2020 and dementia-free controls. Exposures were hospital-diagnosed infections and autoimmune diseases in the preceding 35 years. Two groups of dementia cases were those diagnosed in memory clinics (MC) and those diagnosed outside memory clinics (non-memory clinic cases, NMC). Results: In total, 26,738 individuals were MC and 12,534 were NMC cases. Following any infection, the incidence rate ratio (IRR) for MC cases was 1.23 (95% CI 1.20–1.27) and 1.70 for NMC cases (1.62–1.76). Long-term increased rates were seen for vascular dementia and NMC cases. IRRs for autoimmune diseases were overall statistically insignificant. Conclusions: Cases with vascular dementia and not Alzheimer’s disease, and a subgroup of cases identified with poorer health have increased long-term risk following infections. Autoimmune diseases were not associated with any type of dementia. Notably increased risks (attributed to the short term) and for NMC cases may indicate that immunosenescence rather than de novo infection explains the links. Future focus on such groups and on the role of vascular pathology will explain the infection-dementia links, especially in the long term. |
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| ISSN: | 18758908 13872877 |
| DOI: | 10.3233/jad-231349 |