Vitamin and dietary supplements are not associated with total or cardiovascular mortality in Switzerland: the CoLaus|PsyCoLaus prospective study
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| Názov: | Vitamin and dietary supplements are not associated with total or cardiovascular mortality in Switzerland: the CoLaus|PsyCoLaus prospective study |
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| Autori: | Rosa Lourenço, Pedro-Marques Vidal |
| Zdroj: | Eur J Nutr European journal of nutrition, vol. 64, no. 2, pp. 81 |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2025. |
| Rok vydania: | 2025 |
| Predmety: | Male, Incidence, Original Contribution, Vitamins, Middle Aged, Cohort Studies, Humans, Female, Switzerland/epidemiology, Prospective Studies, Dietary Supplements/statistics & numerical data, Cardiovascular Diseases/mortality, Cardiovascular Diseases/epidemiology, Vitamins/administration & dosage, Aged, Follow-Up Studies, Risk Factors, Cardiovascular disease, Mortality, Prospective study, Vitamin supplements, Cardiovascular Diseases, Dietary Supplements, Switzerland |
| Popis: | Purpose Vitamin-mineral and dietary supplements (VMDS) are taken by a large fraction of the population. Whether their long-term consumption impacts mortality and cardiovascular disease (CVD) has seldom been studied. Methods Prospective study from a population-based cohort from Lausanne, Switzerland. Participants were categorized as non-users (no consumption at baseline and first follow-up), persistent users (consumption at baseline and follow-up), and occasional users (consumption either at baseline or follow-up). Incidence of CVD and of total mortality was assessed after the first follow-up. Results Data from 4261 participants (57.4 ± 10.4 years, 55% females) was used. Median follow-up was 9 years (interquartile range 7.0–9.2) After multivariable analysis, no association was found between VMDS use and total mortality: hazard ratio and (95% confidence interval) 0.95 (0.71–1.28) and 0.83 (0.55–1.26) for occasional and persistent consumers, respectively, CVD mortality: 1.00 (0.47–2.11) and 1.30 (0.53–3.18), or CVD events: 0.96 (0.72–1.27) and 0.95 (0.64–1.42). Similar findings were obtained after inverse probability weighting, using only vitamin-mineral supplement users, or considering only participants at baseline. When CVD events were split into coronary heart disease (CHD) or stroke, persistent use of VMDS was associated with a higher risk of CHD in females: 3.12 (1.52–6.41), p = 0.002, but not in males, 0.25 (0.03–1.82), p = 0.171, p for interaction Conclusion We found no association between vitamin and dietary supplement use and total or CVD mortality, or CVD events. The higher risk of CHD for persistent use in females should be further explored. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1436-6215 1436-6207 |
| DOI: | 10.1007/s00394-025-03593-1 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39891733 http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_624C067DF2E43 https://serval.unil.ch/notice/serval:BIB_624C067DF2E4 https://serval.unil.ch/resource/serval:BIB_624C067DF2E4.P001/REF.pdf |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....d0cb10289cfd22e1738223dc094bae64 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Purpose Vitamin-mineral and dietary supplements (VMDS) are taken by a large fraction of the population. Whether their long-term consumption impacts mortality and cardiovascular disease (CVD) has seldom been studied. Methods Prospective study from a population-based cohort from Lausanne, Switzerland. Participants were categorized as non-users (no consumption at baseline and first follow-up), persistent users (consumption at baseline and follow-up), and occasional users (consumption either at baseline or follow-up). Incidence of CVD and of total mortality was assessed after the first follow-up. Results Data from 4261 participants (57.4 ± 10.4 years, 55% females) was used. Median follow-up was 9 years (interquartile range 7.0–9.2) After multivariable analysis, no association was found between VMDS use and total mortality: hazard ratio and (95% confidence interval) 0.95 (0.71–1.28) and 0.83 (0.55–1.26) for occasional and persistent consumers, respectively, CVD mortality: 1.00 (0.47–2.11) and 1.30 (0.53–3.18), or CVD events: 0.96 (0.72–1.27) and 0.95 (0.64–1.42). Similar findings were obtained after inverse probability weighting, using only vitamin-mineral supplement users, or considering only participants at baseline. When CVD events were split into coronary heart disease (CHD) or stroke, persistent use of VMDS was associated with a higher risk of CHD in females: 3.12 (1.52–6.41), p = 0.002, but not in males, 0.25 (0.03–1.82), p = 0.171, p for interaction Conclusion We found no association between vitamin and dietary supplement use and total or CVD mortality, or CVD events. The higher risk of CHD for persistent use in females should be further explored. |
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| ISSN: | 14366215 14366207 |
| DOI: | 10.1007/s00394-025-03593-1 |