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Joint effect of cognitive function and C-reactive protein on all-cause mortality risk: 1999–2002 NHANES

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Název: Joint effect of cognitive function and C-reactive protein on all-cause mortality risk: 1999–2002 NHANES
Autoři: Madeline B. Zipperer, James R. Churilla, Jessica N. Stapleton, Michael R. Richardson
Zdroj: Annals of Epidemiology. 74:111-117
Informace o vydavateli: Elsevier BV, 2022.
Rok vydání: 2022
Témata: Inflammation, Male, Aging, Cognition (physiology), Cognitive Dysfunction (blood, Middle Aged, Biomarkers (blood), Nutrition Surveys, C-reactive protein, 3. Good health, 03 medical and health sciences, C-Reactive Protein, Cognition, 0302 clinical medicine, Cognitive dysfunction, C-Reactive Protein (analysis), Risk Factors, Humans, Cognitive Dysfunction, Female, Mortality, mortality), Biomarkers, Aged
Popis: Examine the joint effect of cognitive function and C-reactive protein (CRP) on all-cause mortality risk in older U.S. adults.Sample included 1335 older adult (≥60 years of age) participants in the 1999-2002 National Health and Nutrition Examination Survey. A four-level variable was created using cognitive function and CRP concentration. Mortality was assessed using National Center for Health Statistics linked death records from the National Death Index.Increased risk of all-cause mortality was revealed in adults with high CRP and low cognitive function and in those with low to average CRP and low cognitive function (P < .0001 for both). Sex-stratified analyses revealed increased all-cause mortality risk in males with low cognitive function, independent of CRP concentration. However, in females, a significant increase in all-cause mortality risk was only observed in those with low to average CRP and low cognitive function.Low cognitive function was associated with increased all-cause mortality risk independent of CRP concentration. However, the joint effect of cognitive function and CRP on all-cause mortality risk differed according to sex.
Druh dokumentu: Article
Jazyk: English
ISSN: 1047-2797
DOI: 10.1016/j.annepidem.2022.07.003
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/35868614
Rights: Elsevier TDM
Přístupové číslo: edsair.doi.dedup.....d09e08f0c0c24a157a30fa2a803ca5f0
Databáze: OpenAIRE
Popis
Abstrakt:Examine the joint effect of cognitive function and C-reactive protein (CRP) on all-cause mortality risk in older U.S. adults.Sample included 1335 older adult (≥60 years of age) participants in the 1999-2002 National Health and Nutrition Examination Survey. A four-level variable was created using cognitive function and CRP concentration. Mortality was assessed using National Center for Health Statistics linked death records from the National Death Index.Increased risk of all-cause mortality was revealed in adults with high CRP and low cognitive function and in those with low to average CRP and low cognitive function (P < .0001 for both). Sex-stratified analyses revealed increased all-cause mortality risk in males with low cognitive function, independent of CRP concentration. However, in females, a significant increase in all-cause mortality risk was only observed in those with low to average CRP and low cognitive function.Low cognitive function was associated with increased all-cause mortality risk independent of CRP concentration. However, the joint effect of cognitive function and CRP on all-cause mortality risk differed according to sex.
ISSN:10472797
DOI:10.1016/j.annepidem.2022.07.003