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Increased proliferation is associated with CNS invasion in meningiomas

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Název: Increased proliferation is associated with CNS invasion in meningiomas
Autoři: Felix Behling, Christina Fodi, Sophie Wang, Johann-Martin Hempel, Elgin Hoffmann, Ghazaleh Tabatabai, Jürgen Honegger, Marcos Tatagiba, Jens Schittenhelm, Marco Skardelly
Zdroj: J Neurooncol
Informace o vydavateli: Springer Science and Business Media LLC, 2021.
Rok vydání: 2021
Témata: 0301 basic medicine, 03 medical and health sciences, Ki-67 Antigen, 0302 clinical medicine, Laboratory Investigation, Meningeal Neoplasms, Meningeal Neoplasms/pathology [MeSH], Cell Proliferation [MeSH], MIB1, CNS invasion, Humans [MeSH], Retrospective Studies [MeSH], Brain invasion, Ki-67 Antigen/analysis [MeSH], Meningioma/pathology [MeSH], Proliferation, Ki67, Meningioma, Humans, Cell Proliferation, Retrospective Studies
Popis: Introduction Meningiomas are the most common benign intracranial neoplasms. CNS invasion in meningiomas has been integrated into the 2016 WHO classification of CNS tumors as a stand-alone criterion for atypia. Since then, its prognostic impact has been debated based on contradictory results from retrospective analyses. The aim of the study was to elucidate whether histopathological evidence of CNS invasion is associated with increased proliferative potential. Methods We have conducted a quantified measurement of the proliferation marker Ki67 and analyzed its association with CNS invasion determined by histology together with other established prognostic markers of progression. Routine, immunohistochemical staining for Ki67 were digitalized and automatic quantification was done using Image J software. Results Overall, 1718 meningiomas were assessed. Histopathological CNS invasion was seen in 108 cases (6.7%). Uni- and multivariate analysis revealed a significantly higher Ki67 proliferation rate in meningiomas with CNS invasion (p Conclusions Meningiomas with histopathological CNS invasion show a higher proliferative activity.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1573-7373
0167-594X
DOI: 10.1007/s11060-021-03892-7
Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s11060-021-03892-7.pdf
https://pubmed.ncbi.nlm.nih.gov/34800210
https://link.springer.com/article/10.1007/s11060-021-03892-7
https://link.springer.com/content/pdf/10.1007/s11060-021-03892-7.pdf
https://www.ncbi.nlm.nih.gov/pubmed/34800210
https://paperity.org/p/275985216/increased-proliferation-is-associated-with-cns-invasion-in-meningiomas
https://repository.publisso.de/resource/frl:6445971
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) .
Přístupové číslo: edsair.doi.dedup.....d0574b6125064418b3549a7f6b08d967
Databáze: OpenAIRE
Popis
Abstrakt:Introduction Meningiomas are the most common benign intracranial neoplasms. CNS invasion in meningiomas has been integrated into the 2016 WHO classification of CNS tumors as a stand-alone criterion for atypia. Since then, its prognostic impact has been debated based on contradictory results from retrospective analyses. The aim of the study was to elucidate whether histopathological evidence of CNS invasion is associated with increased proliferative potential. Methods We have conducted a quantified measurement of the proliferation marker Ki67 and analyzed its association with CNS invasion determined by histology together with other established prognostic markers of progression. Routine, immunohistochemical staining for Ki67 were digitalized and automatic quantification was done using Image J software. Results Overall, 1718 meningiomas were assessed. Histopathological CNS invasion was seen in 108 cases (6.7%). Uni- and multivariate analysis revealed a significantly higher Ki67 proliferation rate in meningiomas with CNS invasion (p Conclusions Meningiomas with histopathological CNS invasion show a higher proliferative activity.
ISSN:15737373
0167594X
DOI:10.1007/s11060-021-03892-7