Ethical considerations for modern molecular pathology
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| Title: | Ethical considerations for modern molecular pathology |
|---|---|
| Authors: | Shoko Vos, Paul J van Diest, Margreet GEM Ausems, Marijke R van Dijk, Wendy WJ de Leng, Annelien L Bredenoord |
| Contributors: | Pathologie Opleiding, Pathologie, Cancer, Genetica Klinische Genetica, Child Health, Pathologie Pathologen staf, Pathologie Laboratorium diagnostiek, Medical Humanities Onderzoek Team 1, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodology |
| Source: | The Journal of Pathology. 246:405-414 |
| Publisher Information: | Wiley, 2018. |
| Publication Year: | 2018 |
| Subject Terms: | 0301 basic medicine, Genetic Privacy/ethics, Genetic Counseling, Sequence Analysis, DNA/ethics, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, molecular pathology, Predictive Value of Tests, Neoplasms, Journal Article, Biomarkers, Tumor, cancer, Humans, genetics, Genetic Predisposition to Disease, Pathology, Molecular, Practice Patterns, Physicians', Genetic Privacy, DNA, Neoplasm/genetics, Genetic Counseling/ethics, Pathologists/ethics, 0303 health sciences, Informed Consent, Reproducibility of Results, personalized medicine, DNA, Neoplasm, Sequence Analysis, DNA, Informed Consent/ethics, Pathology, Molecular/ethics, ethics, Neoplasms/genetics, 3. Good health, Pathologists, Guideline Adherence/ethics, Phenotype, Practice Guidelines as Topic, Practice Patterns, Physicians'/ethics, pathology, next-generation sequencing, Guideline Adherence, Biomarkers, Tumor/genetics |
| Description: | Molecular pathology is becoming an increasingly important discipline in oncology as molecular tumor characteristics will increasingly determine targeted clinical cancer care. In recent years, many technological advances have taken place that contributed to the development of molecular pathology. However, attention to ethical aspects has been lagging behind as illustrated by the lack of publications or professional guidelines. Existing guidelines or publications on ethical aspects of DNA sequencing are mostly aimed at germline or tumor sequencing in clinical genetics or biomedical research settings. As a result, large differences have been demonstrated in the process of tumor sequencing analysis between laboratories. In this perspective we discuss the ethical issues to consider in molecular pathology by following the process of tumor DNA sequencing analysis from the preanalytical to postanalytical phase. For the successful and responsible use of DNA sequencing in clinical cancer care, several moral requirements must be met, for example, those related to the interpretation and returning of genetic results, informed consent, and the retrospective as well as future use of genetic data for biomedical research. Many ethical issues are new to pathology or more stringent than in current practice because DNA sequencing could yield sensitive and potentially relevant data, such as clinically significant unsolicited findings. The context of molecular pathology is unique and complex, but many issues are similar to those applicable to clinical genetics. As such, existing scholarship in this discipline may be translated to molecular pathology with some adaptations and could serve as a basis for guideline development. For responsible use and further development of clinical cancer care, we recommend that pathologists take responsibility for the adequate use of molecular analyses and be fully aware and capable of dealing with the diverse, complex, and challenging aspects of tumor DNA sequencing, including its ethical issues. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1096-9896 0022-3417 |
| DOI: | 10.1002/path.5157 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/30125358 https://dspace.library.uu.nl/handle/1874/388470 https://europepmc.org/article/MED/30125358 https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201802258422339550 https://www.ncbi.nlm.nih.gov/pubmed/30125358 https://www.narcis.nl/publication/RecordID/oai%3Adspace.library.uu.nl%3A1874%2F388470 https://onlinelibrary.wiley.com/doi/abs/10.1002/path.5157 https://dspace.library.uu.nl/handle/1874/388470 |
| Rights: | Wiley Online Library User Agreement |
| Accession Number: | edsair.doi.dedup.....cffd78fedbc40877fa0cc72da167ce9a |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Molecular pathology is becoming an increasingly important discipline in oncology as molecular tumor characteristics will increasingly determine targeted clinical cancer care. In recent years, many technological advances have taken place that contributed to the development of molecular pathology. However, attention to ethical aspects has been lagging behind as illustrated by the lack of publications or professional guidelines. Existing guidelines or publications on ethical aspects of DNA sequencing are mostly aimed at germline or tumor sequencing in clinical genetics or biomedical research settings. As a result, large differences have been demonstrated in the process of tumor sequencing analysis between laboratories. In this perspective we discuss the ethical issues to consider in molecular pathology by following the process of tumor DNA sequencing analysis from the preanalytical to postanalytical phase. For the successful and responsible use of DNA sequencing in clinical cancer care, several moral requirements must be met, for example, those related to the interpretation and returning of genetic results, informed consent, and the retrospective as well as future use of genetic data for biomedical research. Many ethical issues are new to pathology or more stringent than in current practice because DNA sequencing could yield sensitive and potentially relevant data, such as clinically significant unsolicited findings. The context of molecular pathology is unique and complex, but many issues are similar to those applicable to clinical genetics. As such, existing scholarship in this discipline may be translated to molecular pathology with some adaptations and could serve as a basis for guideline development. For responsible use and further development of clinical cancer care, we recommend that pathologists take responsibility for the adequate use of molecular analyses and be fully aware and capable of dealing with the diverse, complex, and challenging aspects of tumor DNA sequencing, including its ethical issues. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
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| ISSN: | 10969896 00223417 |
| DOI: | 10.1002/path.5157 |