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Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review: A Systematic Review

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Názov: Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review: A Systematic Review
Autori: H. Cao Dinh, I. Beyer, T. Mets, O. O. Onyema, R. Njemini, W. Renmans, M. De Waele, K. Jochmans, S. Vander Meeren, I. Bautmans
Prispievatelia: Faculty of Medicine and Pharmacy, Gerontology, FORMER_Frailty in Ageing, Research in Geriatrics and Gerontology, Vriendenkring VUB, FORMER_Hematology, FORMER_Reproductive immunology and implantation, Clinical sciences, Rehabilitation Research
Zdroj: Calcified Tissue International. 100:193-215
Informácie o vydavateľovi: Springer Science and Business Media LLC, 2016.
Rok vydania: 2016
Predmety: immunosenescence, exercise, Immunosenescence/physiology, Immunosenescence, biomarkers, elderly, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Physical Conditioning, Animal/physiology, Physical Conditioning, Animal, Exercise/physiology, Animals, Humans, Surface marker, Exercise, Biomarkers
Popis: Aging affects negatively the immune system, defined as immunosenescence, which increases the susceptibility of elderly persons to infection, autoimmune disease, and cancer. There are strong indications that physical exercise in elderly persons may prevent the age-related decline in immune response without significant side effects. Consequently, exercise is being considered as a safe mode of intervention to reduce immunosenescence. The aim of this review was to appraise the existing evidence regarding the impact of exercise on surface markers of cellular immunosenescence in either young and old humans or animals. PubMed and Web of Science were systematically screened, and 28 relevant articles in humans or animals were retrieved. Most of the intervention studies demonstrated that an acute bout of exercise induced increases in senescent, naïve, memory CD4+ and CD8+ T-lymphocytes and significantly elevated apoptotic lymphocytes in peripheral blood. As regards long-term effects, exercise induced increased levels of T-lymphocytes expressing CD28+ in both young and elderly subjects. Few studies found an increase in natural killer cell activity following a period of training. We can conclude that exercise has considerable effects on markers of cellular aspects of the immune system. However, very few studies have been conducted so far to investigate the effects of exercise on markers of cellular immunosenescence in elderly persons. Implications for immunosenescence need further investigation.
Druh dokumentu: Article
Jazyk: English
ISSN: 1432-0827
0171-967X
DOI: 10.1007/s00223-016-0212-9
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/27866236
https://researchportal.vub.be/en/publications/effects-of-physical-exercise-on-markers-of-cellular-immunosenesce
https://europepmc.org/article/MED/27866236
https://pubmed.ncbi.nlm.nih.gov/27866236/
https://www.ncbi.nlm.nih.gov/pubmed/27866236
https://link.springer.com/article/10.1007/s00223-016-0212-9
https://biblio.vub.ac.be/vubir/(b5a5f08f-79c5-4060-bce7-10e968428f9b).html
Rights: Springer TDM
Prístupové číslo: edsair.doi.dedup.....cd3978e160f1f2a3f904b6ed77b28dba
Databáza: OpenAIRE
Popis
Abstrakt:Aging affects negatively the immune system, defined as immunosenescence, which increases the susceptibility of elderly persons to infection, autoimmune disease, and cancer. There are strong indications that physical exercise in elderly persons may prevent the age-related decline in immune response without significant side effects. Consequently, exercise is being considered as a safe mode of intervention to reduce immunosenescence. The aim of this review was to appraise the existing evidence regarding the impact of exercise on surface markers of cellular immunosenescence in either young and old humans or animals. PubMed and Web of Science were systematically screened, and 28 relevant articles in humans or animals were retrieved. Most of the intervention studies demonstrated that an acute bout of exercise induced increases in senescent, naïve, memory CD4+ and CD8+ T-lymphocytes and significantly elevated apoptotic lymphocytes in peripheral blood. As regards long-term effects, exercise induced increased levels of T-lymphocytes expressing CD28+ in both young and elderly subjects. Few studies found an increase in natural killer cell activity following a period of training. We can conclude that exercise has considerable effects on markers of cellular aspects of the immune system. However, very few studies have been conducted so far to investigate the effects of exercise on markers of cellular immunosenescence in elderly persons. Implications for immunosenescence need further investigation.
ISSN:14320827
0171967X
DOI:10.1007/s00223-016-0212-9