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Nicotine reduces discrimination between threat and safety in the hippocampus, nucleus accumbens and amygdala

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Název: Nicotine reduces discrimination between threat and safety in the hippocampus, nucleus accumbens and amygdala
Autoři: Madeleine Mueller, Tahmine Fadai, Jonas Rauh, Jan Haaker
Zdroj: Transl Psychiatry
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Translational Psychiatry, 14(1):319
Informace o vydavateli: Cold Spring Harbor Laboratory, 2023.
Rok vydání: 2023
Témata: Male, Adult, 0301 basic medicine, Nicotine, Neurosciences. Biological psychiatry. Neuropsychiatry, Fear, Amygdala, Hippocampus, Magnetic Resonance Imaging, Article, Nucleus Accumbens, Extinction, Psychological, 3. Good health, Young Adult, 03 medical and health sciences, Discrimination, Psychological, 0302 clinical medicine, Double-Blind Method, Humans, Female, Nicotinic Agonists, Double-Blind Method [MeSH], Nicotinic Agonists/pharmacology [MeSH], Nicotine/pharmacology [MeSH], Nucleus Accumbens/drug effects [MeSH], Magnetic Resonance Imaging [MeSH], Male [MeSH], Nicotinic Agonists/administration, Fear/drug effects [MeSH], Female [MeSH], Nicotine/adverse effects [MeSH], Adult [MeSH], Humans [MeSH], Nicotinic Agonists/adverse effects [MeSH], Amygdala/drug effects [MeSH], Extinction, Psychological/drug effects [MeSH], 631/477/2811, 631/378/1595/1554, Nicotine/administration, Nucleus Accumbens/diagnostic imaging [MeSH], Discrimination, Psychological/drug effects [MeSH], Young Adult [MeSH], Amygdala/diagnostic imaging [MeSH], Hippocampus/drug effects [MeSH], article, RC321-571
Popis: Nicotine intake by cigarettes is linked to the maintenance and development of anxiety disorders and impairs adaptive discrimination of threat and safety in humans. Yet, it is unclear if nicotine exerts a causal pharmacological effect on the affective and neural mechanisms that underlie aversive learning. We conducted a pre-registered, pseudo-randomly and double-blinded pharmacological fMRI study to investigate the effect of acute nicotine on Fear Acquisition and Extinction in non-smokers (n=88). Our results show that nicotine administration led to decreased discrimination between threat and safety in subjective fear. Nicotine furthermore decreased differential (threat vs. safety) activation in the hippocampus, which was functionally coupled with Nucleus Accumbens and amygdala, compared to placebo controls. Additionally, nicotine led to overactivation of the ventral tegmental area. This study provides mechanistic evidence that single doses of nicotine impair neural substrates of adaptive aversive learning in line with the risk for the development of pathological anxiety.
Druh dokumentu: Article
Other literature type
ISSN: 2158-3188
DOI: 10.1101/2023.05.08.23289647
DOI: 10.1038/s41398-024-03040-5
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39097609
https://doaj.org/article/b65cdb13fda143efa8620a52a6b16f45
https://repository.publisso.de/resource/frl:6507834
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....cb9c5501f26eb804e25776eba1a473b6
Databáze: OpenAIRE
Popis
Abstrakt:Nicotine intake by cigarettes is linked to the maintenance and development of anxiety disorders and impairs adaptive discrimination of threat and safety in humans. Yet, it is unclear if nicotine exerts a causal pharmacological effect on the affective and neural mechanisms that underlie aversive learning. We conducted a pre-registered, pseudo-randomly and double-blinded pharmacological fMRI study to investigate the effect of acute nicotine on Fear Acquisition and Extinction in non-smokers (n=88). Our results show that nicotine administration led to decreased discrimination between threat and safety in subjective fear. Nicotine furthermore decreased differential (threat vs. safety) activation in the hippocampus, which was functionally coupled with Nucleus Accumbens and amygdala, compared to placebo controls. Additionally, nicotine led to overactivation of the ventral tegmental area. This study provides mechanistic evidence that single doses of nicotine impair neural substrates of adaptive aversive learning in line with the risk for the development of pathological anxiety.
ISSN:21583188
DOI:10.1101/2023.05.08.23289647