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Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases

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Názov: Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases
Autori: Mitra Pirhaghi, Fatemeh Mamashli, Faezeh Moosavi-Movahedi, Payam Arghavani, Ahmad Amiri, Bagher Davaeil, Mahya Mohammad-Zaheri, Zahra Mousavi-Jarrahi, Deepak Sharma, Ülo Langel, Daniel Erik Otzen, Ali Akbar Saboury
Zdroj: Pirhaghi, M, Mamashli, F, Moosavi-Movahedi, F, Arghavani, P, Amiri, A, Davaeil, B, Mohammad-Zaheri, M, Mousavi-Jarrahi, Z, Sharma, D, Langel, Ü, Otzen, D E & Saboury, A A 2024, 'Cell-Penetrating Peptides : Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases', Molecular Pharmaceutics, vol. 21, no. 5, pp. 2097-2117. https://doi.org/10.1021/acs.molpharmaceut.3c01167
Informácie o vydavateľovi: American Chemical Society (ACS), 2024.
Rok vydania: 2024
Predmety: cell-penetrating peptides, Alzheimer Disease/drug therapy, central nervous system disorders, Alzheimer's disease (AD), Neurodegenerative Diseases, Parkinson Disease, Cell-Penetrating Peptides, Parkinson's disease (PD), 3. Good health, peptide-nanoparticle conjugate, Cell-Penetrating Peptides/chemistry, Drug Delivery Systems, Blood-Brain Barrier, Alzheimer Disease, drug delivery, Neurodegenerative Diseases/drug therapy, Drug Delivery Systems/methods, Humans, Nanoparticles, Animals, Nanoparticles/chemistry, Parkinson Disease/drug therapy, Blood-Brain Barrier/metabolism
Popis: Currently, one of the most significant and rapidly growing unmet medical challenges is the treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). This challenge encompasses the imperative development of efficacious therapeutic agents and overcoming the intricacies of the blood-brain barrier for successful drug delivery. Here we focus on the delivery aspect with particular emphasis on cell-penetrating peptides (CPPs), widely used in basic and translational research as they enhance drug delivery to challenging targets such as tissue and cellular compartments and thus increase therapeutic efficacy. The combination of CPPs with nanomaterials such as nanoparticles (NPs) improves the performance, accuracy, and stability of drug delivery and enables higher drug loads. Our review presents and discusses research that utilizes CPPs, either alone or in conjugation with NPs, to mitigate the pathogenic effects of neurodegenerative diseases with particular reference to AD and PD.
Druh dokumentu: Article
Jazyk: English
ISSN: 1543-8392
1543-8384
DOI: 10.1021/acs.molpharmaceut.3c01167
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38440998
Rights: STM Policy #29
Prístupové číslo: edsair.doi.dedup.....caf82a7e8620bff6b7f9f37754fb95a3
Databáza: OpenAIRE
Popis
Abstrakt:Currently, one of the most significant and rapidly growing unmet medical challenges is the treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). This challenge encompasses the imperative development of efficacious therapeutic agents and overcoming the intricacies of the blood-brain barrier for successful drug delivery. Here we focus on the delivery aspect with particular emphasis on cell-penetrating peptides (CPPs), widely used in basic and translational research as they enhance drug delivery to challenging targets such as tissue and cellular compartments and thus increase therapeutic efficacy. The combination of CPPs with nanomaterials such as nanoparticles (NPs) improves the performance, accuracy, and stability of drug delivery and enables higher drug loads. Our review presents and discusses research that utilizes CPPs, either alone or in conjugation with NPs, to mitigate the pathogenic effects of neurodegenerative diseases with particular reference to AD and PD.
ISSN:15438392
15438384
DOI:10.1021/acs.molpharmaceut.3c01167