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A family of putative metalloproteases in the salivary glands of the tick Ixodes ricinus

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Název: A family of putative metalloproteases in the salivary glands of the tick Ixodes ricinus
Autoři: Decrem, Yves, Beaufays, Jérôme, Blasioli, Virginie, Lahaye, Katia, Brossard, Michel, Vanhamme, Luc, Godfroid, Edmond
Zdroj: The FEBS Journal. 275:1485-1499
Informace o vydavateli: Wiley, 2008.
Rok vydání: 2008
Témata: Male, 0301 basic medicine, Arachnid Vectors -- genetics, Evolution, Ixodes -- enzymology, Metalloproteases -- physiology, Molecular Sequence Data, Salivary Glands -- enzymology, Salivary Glands, Evolution, Molecular, Mice, 03 medical and health sciences, Salivary Proteins and Peptides -- genetics, Animals, Amino Acid Sequence, Salivary Proteins and Peptides, Metalloproteases -- genetics, 0303 health sciences, Ixodes, Arachnid Vectors -- enzymology, Molecular, Sciences bio-médicales et agricoles, Multigene Family, Metalloproteases, Ixodes -- genetics, Arachnid Vectors, Female, Rabbits, Salivary Proteins and Peptides -- physiology
Popis: Ticks are obligate blood‐feeding arachnids. During their long‐lasting blood meal, they have to counteract the protective barriers and defense mechanisms of their host. These include tissue integrity, pain, hemostasis, and the inflammatory and immune reactions. Here, we describe a multigene family coding for five putative salivary metalloproteases induced during the blood meal of Ixodes ricinus. The evolutionary divergence inside the family was driven by positive Darwinian selection. This came together with individual variation of expression, functional heterogeneity, and antigenic diversification. Inhibition of the expression of some of these genes by RNA interference prevented completion of the tick blood meal and affected the ability of the tick saliva to interfere with host fibrinolysis. This family of proteins could therefore participate in the inhibition of wound healing after the tick bite, thereby facilitating the completion of the blood meal.
Druh dokumentu: Article
Popis souboru: 2 full-text file(s): application/pdf; application/pdf
Jazyk: English
ISSN: 1742-4658
1742-464X
DOI: 10.1111/j.1742-4658.2008.06308.x
Přístupová URL adresa: https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-4658.2008.06308.x
https://pubmed.ncbi.nlm.nih.gov/18279375
https://europepmc.org/abstract/MED/18279375
http://doc.rero.ch/record/11969
https://pubmed.ncbi.nlm.nih.gov/18279375/
https://doc.rero.ch/record/11969/files/Decrem_Yves_-_A_family_of_putative_metalloproteases_20090602.pdf
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51913/Details
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1742-4658.2008.06308.x
Rights: Wiley Online Library User Agreement
Přístupové číslo: edsair.doi.dedup.....ca4a2cbf5e1ce21f187eed25304efe1f
Databáze: OpenAIRE
Popis
Abstrakt:Ticks are obligate blood‐feeding arachnids. During their long‐lasting blood meal, they have to counteract the protective barriers and defense mechanisms of their host. These include tissue integrity, pain, hemostasis, and the inflammatory and immune reactions. Here, we describe a multigene family coding for five putative salivary metalloproteases induced during the blood meal of Ixodes ricinus. The evolutionary divergence inside the family was driven by positive Darwinian selection. This came together with individual variation of expression, functional heterogeneity, and antigenic diversification. Inhibition of the expression of some of these genes by RNA interference prevented completion of the tick blood meal and affected the ability of the tick saliva to interfere with host fibrinolysis. This family of proteins could therefore participate in the inhibition of wound healing after the tick bite, thereby facilitating the completion of the blood meal.
ISSN:17424658
1742464X
DOI:10.1111/j.1742-4658.2008.06308.x