Preconditioning Strategies for Improving the Outcome of Fat Grafting
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| Title: | Preconditioning Strategies for Improving the Outcome of Fat Grafting |
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| Authors: | Bonomi, Francesca, Limido, Ettore, Weinzierl, Andrea, Harder, Yves, Menger, Michael D, Laschke, Matthias W |
| Contributors: | University of Zurich, Laschke, Matthias W |
| Source: | Tissue Engineering Part B: Reviews. 31:94-108 |
| Publisher Information: | Mary Ann Liebert Inc, 2025. |
| Publication Year: | 2025 |
| Subject Terms: | 1303 Biochemistry, Transplantation Conditioning, 1502 Bioengineering, fasting, hypoxia, 2502 Biomaterials, 2204 Biomedical Engineering, 610 Medicine & health, survival, adipose tissue, Adipose Tissue, preconditioning, Humans, Animals, 10266 Clinic for Reconstructive Surgery, Ischemic Preconditioning, fat grafting |
| Description: | Autologous fat grafting is a common procedure in plastic, reconstructive, and aesthetic surgery. However, it is frequently associated with an unpredictable resorption rate of the graft depending on the engraftment kinetics. This, in turn, is determined by the interaction of the grafted adipose tissue with the tissue at the recipient site. Accordingly, preconditioning strategies have been developed following the principle of exposing these tissues in the pretransplantation phase to stimuli inducing endogenous protective and regenerative cellular adaptations, such as the upregulation of stress-response genes or the release of cytokines and growth factors. As summarized in the present review, these stimuli include hypoxia, dietary restriction, local mechanical stress, heat, and exposure to fractional carbon dioxide laser. Preclinical studies show that they promote cell viability, adipogenesis, and angiogenesis, while reducing inflammation, fibrosis, and cyst formation, resulting in a higher survival rate and quality of fat grafts in different experimental settings. Hence, preconditioning represents a promising approach to improve the outcome of fat grafting in future clinical practice. For this purpose, it is necessary to establish standardized preconditioning protocols for specific clinical applications that are efficient, safe, and easy to implement into routine procedures. |
| Document Type: | Article Other literature type |
| File Description: | ZORA_267540.pdf - application/pdf |
| Language: | English |
| ISSN: | 1937-3376 1937-3368 |
| DOI: | 10.1089/ten.teb.2024.0090 |
| DOI: | 10.5167/uzh-267540 |
| DOI: | 10.22028/d291-45617 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/38818802 https://www.zora.uzh.ch/id/eprint/267540/ https://doi.org/10.5167/uzh-267540 |
| Rights: | Mary Ann Liebert TDM |
| Accession Number: | edsair.doi.dedup.....ca47e8e8de4ae4d3e6b0d8d6039f8e36 |
| Database: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Autologous fat grafting is a common procedure in plastic, reconstructive, and aesthetic surgery. However, it is frequently associated with an unpredictable resorption rate of the graft depending on the engraftment kinetics. This, in turn, is determined by the interaction of the grafted adipose tissue with the tissue at the recipient site. Accordingly, preconditioning strategies have been developed following the principle of exposing these tissues in the pretransplantation phase to stimuli inducing endogenous protective and regenerative cellular adaptations, such as the upregulation of stress-response genes or the release of cytokines and growth factors. As summarized in the present review, these stimuli include hypoxia, dietary restriction, local mechanical stress, heat, and exposure to fractional carbon dioxide laser. Preclinical studies show that they promote cell viability, adipogenesis, and angiogenesis, while reducing inflammation, fibrosis, and cyst formation, resulting in a higher survival rate and quality of fat grafts in different experimental settings. Hence, preconditioning represents a promising approach to improve the outcome of fat grafting in future clinical practice. For this purpose, it is necessary to establish standardized preconditioning protocols for specific clinical applications that are efficient, safe, and easy to implement into routine procedures. |
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| ISSN: | 19373376 19373368 |
| DOI: | 10.1089/ten.teb.2024.0090 |