Calcium in drinking water: effect on iron stores in Danish blood donors—results from the Danish Blood Donor Study: effect on iron stores in Danish blood donors—results from the Danish Blood Donor Study
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| Titel: | Calcium in drinking water: effect on iron stores in Danish blood donors—results from the Danish Blood Donor Study: effect on iron stores in Danish blood donors—results from the Danish Blood Donor Study |
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| Autoren: | Henrik Ullum, Benedikte H. Ejsing, Ole Birger Pedersen, Andreas S. Rigas, Henrik Hjalgrim, Christian Erikstrup, Erik Sørensen |
| Quelle: | Rigas, A S, Ejsing, B H, Sørensen, E, Pedersen, O B, Hjalgrim, H, Erikstrup, C & Ullum, H 2018, ' Calcium in drinking water : effect on iron stores in Danish blood donors—results from the Danish Blood Donor Study ', Transfusion, vol. 58, no. 6, pp. 1468-1473 . https://doi.org/10.1111/trf.14600 Rigas, A S, Ejsing, B H, Sørensen, E, Pedersen, O B, Hjalgrim, H, Erikstrup, C & Ullum, H 2018, 'Calcium in drinking water : effect on iron stores in Danish blood donors-results from the Danish Blood Donor Study', Transfusion, vol. 58, no. 6, pp. 1468-1473. https://doi.org/10.1111/trf.14600 |
| Verlagsinformationen: | Wiley, 2018. |
| Publikationsjahr: | 2018 |
| Schlagwörter: | 0301 basic medicine, 0303 health sciences, Calcium/analysis, Denmark, Drinking Water, Iron, Blood Donors, Iron Deficiencies, 6. Clean water, 03 medical and health sciences, Sex Factors, Drinking Water/chemistry, Humans, Regression Analysis, Calcium, Iron/blood |
| Beschreibung: | BACKGROUNDStudies confirm that calcium inhibits iron absorption. Danish tap water comes from groundwater, which contains varying amounts of calcium depending on the subsoil. We investigated the association of calcium in drinking water with iron levels in Danish blood donors.STUDY DESIGN AND METHODSWe used data on Danish blood donors including dietary and lifestyle habits, blood donation history, and physiologic characteristics including measures of ferritin levels along with information on area of residence from The Danish Blood Donor Study. Data on calcium levels in groundwater (“water hardness”) were obtained through the Geological Survey of Denmark and Greenland. We performed multiple linear and logistic regression analyses to evaluate the effect of water hardness on ferritin levels and risk of having iron deficiency (defined as ferritin levels RESULTSThere was a significant negative association between water hardness and ferritin levels in both men and women. Risk of iron deficiency was correspondingly increased in both men (odds ratio [OR], 1.55; 95% confidence interval [CI], 1.14‐2.12) and women (OR, 1.20; 95% CI, 1.03‐1.40) with increasing water hardness. In analyses restricted to individuals who received supplemental iron tablets no significant association between groundwater hardness and ferritin levels was observed.CONCLUSIONSAs measured by ferritin levels, residential drinking water calcium content is associated with blood donors‐ iron levels and risk of iron deficiency. However, effect sizes are small. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 1537-2995 0041-1132 |
| DOI: | 10.1111/trf.14600 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/29577328 https://pubmed.ncbi.nlm.nih.gov/29577328/ https://www.ncbi.nlm.nih.gov/pubmed/29577328 https://core.ac.uk/display/159785276 https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.14600 https://portal.findresearcher.sdu.dk/da/publications/cb550940-170f-46c9-94f8-a4b6d8a0ff4e https://portal.findresearcher.sdu.dk/da/publications/cb550940-170f-46c9-94f8-a4b6d8a0ff4e https://doi.org/10.1111/trf.14600 |
| Rights: | Wiley Online Library User Agreement |
| Dokumentencode: | edsair.doi.dedup.....ca1e66f2dc4898ba6cc616a65ad8ab87 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | BACKGROUNDStudies confirm that calcium inhibits iron absorption. Danish tap water comes from groundwater, which contains varying amounts of calcium depending on the subsoil. We investigated the association of calcium in drinking water with iron levels in Danish blood donors.STUDY DESIGN AND METHODSWe used data on Danish blood donors including dietary and lifestyle habits, blood donation history, and physiologic characteristics including measures of ferritin levels along with information on area of residence from The Danish Blood Donor Study. Data on calcium levels in groundwater (“water hardness”) were obtained through the Geological Survey of Denmark and Greenland. We performed multiple linear and logistic regression analyses to evaluate the effect of water hardness on ferritin levels and risk of having iron deficiency (defined as ferritin levels RESULTSThere was a significant negative association between water hardness and ferritin levels in both men and women. Risk of iron deficiency was correspondingly increased in both men (odds ratio [OR], 1.55; 95% confidence interval [CI], 1.14‐2.12) and women (OR, 1.20; 95% CI, 1.03‐1.40) with increasing water hardness. In analyses restricted to individuals who received supplemental iron tablets no significant association between groundwater hardness and ferritin levels was observed.CONCLUSIONSAs measured by ferritin levels, residential drinking water calcium content is associated with blood donors‐ iron levels and risk of iron deficiency. However, effect sizes are small. |
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| ISSN: | 15372995 00411132 |
| DOI: | 10.1111/trf.14600 |