Identification of Siglec-1-negative alveolar macrophages with proinflammatory phenotypes in chronic obstructive pulmonary disease
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| Název: | Identification of Siglec-1-negative alveolar macrophages with proinflammatory phenotypes in chronic obstructive pulmonary disease |
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| Autoři: | Takuya Saito, Naoya Fujino, Yorihiko Kyogoku, Mitsuhiro Yamada, Koji Okutomo, Yoshinao Ono, Shuichi Konno, Takuto Endo, Koji Itakura, Shuichiro Matsumoto, Hirohito Sano, Hiroyuki Aizawa, Tadahisa Numakura, Katsuhiro Onodera, Yoshinori Okada, Tracy Hussell, Masakazu Ichinose, Hisatoshi Sugiura |
| Zdroj: | Saito, T, Fujino, N, Kyogoku, Y, Yamada, M, Okutomo, K, Ono, Y, Konno, S, Endo, T, Itakura, K, Matsumoto, S, Sano, H, Aizawa, H, Numakura, T, Onodera, K, Okada, Y, Hussell, T, Ichinose, M & Sugiura, H 2024, 'Identification of Siglec-1-negative alveolar macrophages with proinflammatory phenotypes in chronic obstructive pulmonary disease', American journal of physiology. Lung cellular and molecular physiology, vol. 326, no. 6, pp. L672-L686. https://doi.org/10.1152/ajplung.00303.2023 |
| Informace o vydavateli: | American Physiological Society, 2024. |
| Rok vydání: | 2024 |
| Témata: | Male, Inflammation, 0301 basic medicine, Sialic Acid Binding Ig-like Lectin 1/metabolism, 0303 health sciences, Sialic Acid Binding Ig-like Lectin 1, Macrophages, Chronic Obstructive/metabolism, Inflammation/metabolism, Cytokines/metabolism, Alveolar/metabolism, Middle Aged, 3. Good health, Pulmonary Disease, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, Phenotype, Macrophages, Alveolar, Pulmonary Disease, Chronic Obstructive/metabolism, Humans, Cytokines, Female, Macrophages, Alveolar/metabolism, Aged |
| Popis: | Alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD) orchestrate persistent inflammation in the airway. We find that Siglec-1-negative alveolar macrophages have a wide range of proinflammatory landscapes and a protease-expressing phenotype. Moreover, this subset is associated with the pathogenesis of COPD and responds to viral stimuli. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1522-1504 1040-0605 |
| DOI: | 10.1152/ajplung.00303.2023 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38530936 https://research.manchester.ac.uk/en/publications/998e7a89-c7e1-44f2-a128-23eba5bbf48d https://doi.org/10.1152/ajplung.00303.2023 |
| Přístupové číslo: | edsair.doi.dedup.....c97b648e36580f2faf87af136539e741 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD) orchestrate persistent inflammation in the airway. We find that Siglec-1-negative alveolar macrophages have a wide range of proinflammatory landscapes and a protease-expressing phenotype. Moreover, this subset is associated with the pathogenesis of COPD and responds to viral stimuli. |
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| ISSN: | 15221504 10400605 |
| DOI: | 10.1152/ajplung.00303.2023 |