A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans
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| Titel: | A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans |
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| Autoren: | Umair J. Chaudhary, Louis Lemieux, Tim M. Tierney, Patrícia Figueiredo, David W. Carmichael, Teresa Murta, Li Hu, Matthew C. Walker |
| Quelle: | Neuroimage |
| Verlagsinformationen: | Elsevier BV, 2016. |
| Publikationsjahr: | 2016 |
| Schlagwörter: | SHARP WAVES, Drug Resistant Epilepsy/physiopathology, Drug Resistant Epilepsy, EVENT-RELATED FMRI, Electro-haemodynamic coupling, Electroencephalography/methods, Electroencephalography Phase Synchronization, Electroencephalography Phase Synchronization/physiology, Magnetic Resonance Imaging/methods, Sharp wave, 0302 clinical medicine, Bold, NEGATIVE BOLD, fMRI, Brain, Electroencephalography, FUNCTIONAL MRI, LOCAL-FIELD POTENTIALS, Magnetic Resonance Imaging, Nuclear Medicine & Medical Imaging, Neurology, INTERICTAL EPILEPTIFORM DISCHARGES, NEURONAL-ACTIVITY, BOLD SIGNAL, Radiology, Life Sciences & Biomedicine, Adult, Sharp Wave, Functional Neuroimaging/methods, Cognitive Neuroscience, Neuroimaging, Article, 03 medical and health sciences, Fmri, FIRING PATTERNS, Humans, Intracranial Eeg, Science & Technology, Intracranial EEG, Functional Neuroimaging, Neurosciences, Neurovascular Coupling/physiology, Brain/diagnostic imaging, FOCAL EPILEPSY, Neurovascular Coupling, Electro-haemodynamic Coupling, Neurosciences & Neurology, BOLD |
| Beschreibung: | In current fMRI studies designed to map BOLD changes related to interictal epileptiform discharges (IED), which are recorded on simultaneous EEG, the information contained in the morphology and field extent of the EEG events is exclusively used for their classification. Usually, a BOLD predictor based on IED onset times alone is constructed, effectively treating all events as identical. We used intracranial EEG (icEEG)-fMRI data simultaneously recorded in humans to investigate the effect of including any of the features: amplitude, width (duration), slope of the rising phase, energy (area under the curve), or spatial field extent (number of contacts over which the sharp wave was observed) of the fast wave of the IED (the sharp wave), into the BOLD model, to better understand the neurophysiological origin of sharp wave-related BOLD changes, in the immediate vicinity of the recording contacts. Among the features considered, the width was the only one found to explain a significant amount of additional variance, suggesting that the amplitude of the BOLD signal depends more on the duration of the underlying field potential (reflected in the sharp wave width) than on the degree of neuronal activity synchrony (reflected in the sharp wave amplitude), and, consequently, that including inter-event variations of the sharp wave width in the BOLD signal model may increase the sensitivity of forthcoming EEG-fMRI studies of epileptic activity. |
| Publikationsart: | Article Conference object Other literature type |
| Sprache: | English |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2016.08.001 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/27498370 http://ir.psych.ac.cn/handle/311026/20773 https://core.ac.uk/display/75721796 https://discovery.ucl.ac.uk/1508899/ https://dblp.uni-trier.de/db/journals/neuroimage/neuroimage142.html#MurtaHTCWCFL16 https://www.ncbi.nlm.nih.gov/pubmed/27498370 https://europepmc.org/articles/PMC5102699 https://discovery-pp.ucl.ac.uk/id/eprint/1508899/ |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....c8e10454705ed3a1f435c94f8d114881 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | In current fMRI studies designed to map BOLD changes related to interictal epileptiform discharges (IED), which are recorded on simultaneous EEG, the information contained in the morphology and field extent of the EEG events is exclusively used for their classification. Usually, a BOLD predictor based on IED onset times alone is constructed, effectively treating all events as identical. We used intracranial EEG (icEEG)-fMRI data simultaneously recorded in humans to investigate the effect of including any of the features: amplitude, width (duration), slope of the rising phase, energy (area under the curve), or spatial field extent (number of contacts over which the sharp wave was observed) of the fast wave of the IED (the sharp wave), into the BOLD model, to better understand the neurophysiological origin of sharp wave-related BOLD changes, in the immediate vicinity of the recording contacts. Among the features considered, the width was the only one found to explain a significant amount of additional variance, suggesting that the amplitude of the BOLD signal depends more on the duration of the underlying field potential (reflected in the sharp wave width) than on the degree of neuronal activity synchrony (reflected in the sharp wave amplitude), and, consequently, that including inter-event variations of the sharp wave width in the BOLD signal model may increase the sensitivity of forthcoming EEG-fMRI studies of epileptic activity. |
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| ISSN: | 10538119 |
| DOI: | 10.1016/j.neuroimage.2016.08.001 |