Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex
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| Title: | Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex |
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| Authors: | Anton Sonntag, Carina Kelbsch, Ronja Jung, Helmut Wilhelm, Torsten Strasser, Tobias Peters, Krunoslav Stingl, Barbara Wilhelm |
| Source: | Int Ophthalmol |
| Publisher Information: | Springer Science and Business Media LLC, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | 0301 basic medicine, Original Paper, 03 medical and health sciences, 0302 clinical medicine, Light, Retinal Rod Photoreceptor Cells, Retinal Cone Photoreceptor Cells, Humans, Pupil, Miosis, Reflex, Pupillary, Photic Stimulation, Retinal Cone Photoreceptor Cells [MeSH], Pupillography, Humans [MeSH], Miosis [MeSH], Light [MeSH], Reflex, Pupillary/physiology [MeSH], Centre, Rods, Photic Stimulation [MeSH], Pupil campimetry, Pupil/physiology [MeSH], Cones, Periphery, Retinal Rod Photoreceptor Cells/physiology [MeSH] |
| Description: | Purpose To assess the effect of central and peripheral stimulation on the pupillary light reflex. The aim was to detect possible differences between cone- and rod-driven reactions. Methods Relative maximal pupil constriction amplitude (relMCA) and latency to constriction onset (latency) to cone- and rod-specific stimuli of 30 healthy participants (24 ± 5 years (standard deviation)) were measured using chromatic pupil campimetry. Cone- and rod-specific stimuli had different intensities and wavelengths according to the Standards in Pupillography. Five filled circles with radii of 3°, 5°, 10°, 20° and 40° and four rings with a constant outer radius of 40° and inner radii of 3°, 5°, 10° and 20° were used as stimuli. Results For cone-and rod-specific stimuli, relMCA increased with the stimulus area for both, circles and rings. However, increasing the area of a cone-specific ring by minimizing its inner radius with constant outer radius increased relMCA significantly stronger than the same did for a rod-specific ring. For cones and rods, a circle stimulus with a radius of 40° created a lower relMCA than the summation of the relMCAs to the corresponding ring and circle stimuli which combined create a 40° circle-stimulus. Latency was longer for rods than for cones. It decreased with increasing stimulus area for circle stimuli while it stayed nearly constant with increasing ring stimulus area for cone- and rod-specific stimuli. Conclusion The effect of central stimulation on relMCA is more dominant for cone-specific stimuli than for rod-specific stimuli while latency dynamics are similar for both conditions. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1573-2630 |
| DOI: | 10.1007/s10792-021-02132-1 |
| Access URL: | https://link.springer.com/content/pdf/10.1007/s10792-021-02132-1.pdf https://pubmed.ncbi.nlm.nih.gov/34826023 https://link.springer.com/content/pdf/10.1007/s10792-021-02132-1.pdf https://pubmed.ncbi.nlm.nih.gov/34826023/ https://link.springer.com/article/10.1007/s10792-021-02132-1 https://repository.publisso.de/resource/frl:6444905 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Accession Number: | edsair.doi.dedup.....c83f374638157aa222a2001b71cdf14c |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Purpose To assess the effect of central and peripheral stimulation on the pupillary light reflex. The aim was to detect possible differences between cone- and rod-driven reactions. Methods Relative maximal pupil constriction amplitude (relMCA) and latency to constriction onset (latency) to cone- and rod-specific stimuli of 30 healthy participants (24 ± 5 years (standard deviation)) were measured using chromatic pupil campimetry. Cone- and rod-specific stimuli had different intensities and wavelengths according to the Standards in Pupillography. Five filled circles with radii of 3°, 5°, 10°, 20° and 40° and four rings with a constant outer radius of 40° and inner radii of 3°, 5°, 10° and 20° were used as stimuli. Results For cone-and rod-specific stimuli, relMCA increased with the stimulus area for both, circles and rings. However, increasing the area of a cone-specific ring by minimizing its inner radius with constant outer radius increased relMCA significantly stronger than the same did for a rod-specific ring. For cones and rods, a circle stimulus with a radius of 40° created a lower relMCA than the summation of the relMCAs to the corresponding ring and circle stimuli which combined create a 40° circle-stimulus. Latency was longer for rods than for cones. It decreased with increasing stimulus area for circle stimuli while it stayed nearly constant with increasing ring stimulus area for cone- and rod-specific stimuli. Conclusion The effect of central stimulation on relMCA is more dominant for cone-specific stimuli than for rod-specific stimuli while latency dynamics are similar for both conditions. |
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| ISSN: | 15732630 |
| DOI: | 10.1007/s10792-021-02132-1 |