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Expression of Prox1 in Medullary Thyroid Carcinoma Is Associated with Chromogranin A and Calcitonin Expression and with Ki67 Proliferative Index, but Not with Prognosis

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Title: Expression of Prox1 in Medullary Thyroid Carcinoma Is Associated with Chromogranin A and Calcitonin Expression and with Ki67 Proliferative Index, but Not with Prognosis
Authors: Fausto Sessa, Igor Letovanec, Massimo Bongiovanni, Silvia Uccella, Chiara Saglietti, Tatiana V. Petrova, Gerasimos P. Sykiotis, Jean-Luc Bulliard, Simonetta Piana, Maxime Mermod, Stefano La Rosa
Source: Endocrine Pathology. 30:138-145
Publisher Information: Springer Science and Business Media LLC, 2019.
Publication Year: 2019
Subject Terms: Adult, Calcitonin, Male, 0301 basic medicine, Calcitonin / genetics, Tumor Suppressor Proteins / biosynthesis, Chromogranin A / genetics, Kaplan-Meier Estimate, Homeodomain Proteins / biosynthesis, Carcinoma, Neuroendocrine / pathology, Young Adult, 03 medical and health sciences, CEA, Predictive Value of Tests, Prox1, Medullary thyroid carcinoma, Humans, Thyroid Neoplasms, Aged, Cell Proliferation, Tumor Suppressor Proteins / genetics, Homeodomain Proteins, Ki-67 Antigen / analysis, 0303 health sciences, Homeodomain Proteins / genetics, Calcitonin / analysis, Tumor Suppressor Proteins, Middle Aged, Prognosis, Immunohistochemistry, Survival Analysis, Chromogranin A / analysis, Carcinoma, Neuroendocrine, 3. Good health, Carcinoma, Neuroendocrine / genetics, Ki-67 Antigen, Thyroid Neoplasms / pathology, Chromogranin A, Female, Thyroid Neoplasms / genetics, Ki67
Description: Medullary thyroid carcinoma (MTC) has been shown to express Prospero homeobox protein 1 (Prox1), a transcription factor whose expression is altered in a variety of human cancers. We conducted a retrospective study on a series of 32 patients with MTC to test the correlation of Prox1 expression in MTC with clinicopathological features and to evaluate its prognostic significance. Correlation of Prox1 immunohistochemical expression with tumor size, proliferative index (Ki67), and calcitonin and CEA serum levels prior to surgery was tested for significant correlations. The difference in Prox1 and Ki67 immunohistochemical expression according to the immunohistochemical staining intensity of CEA, chromogranin A, and calcitonin was tested using the Kruskal-Wallis H test and linear regression analysis. The prognostic value of Prox1 and Ki67 for our patient cohort was assessed by Kaplan-Meier log rank survival analysis. We demonstrated a positive correlation between Prox1 expression and Ki67 index. Prox1 also showed significant difference in expression according to chromogranin A and calcitonin immunohistochemical expression, with higher Prox1 expression in tumors with stronger chromogranin A or calcitonin staining. Prox1 expression did not correlate with PFS or OS based on Kaplan-Meier log rank survival analysis. In conclusion, Prox1 expression in MTC is positively correlated with Ki67 and with the immunohistochemical expression of chromogranin A and calcitonin. However, the present study does not support a role for Prox1 in MTC prognosis.
Document Type: Article
File Description: application/pdf
Language: English
ISSN: 1559-0097
1046-3976
DOI: 10.1007/s12022-019-9576-5
Access URL: https://pubmed.ncbi.nlm.nih.gov/31001799
https://infoscience.epfl.ch/record/267168
https://moh-it.pure.elsevier.com/en/publications/expression-of-prox1-in-medullary-thyroid-carcinoma-is-associated-
https://serval.unil.ch/notice/serval:BIB_564B70BCE78F
https://www.ncbi.nlm.nih.gov/pubmed/31001799
https://pubmed.ncbi.nlm.nih.gov/31001799/
https://link.springer.com/article/10.1007/s12022-019-9576-5
https://archive-ouverte.unige.ch/unige:179973
https://doi.org/10.1007/s12022-019-9576-5
Rights: Springer TDM
Accession Number: edsair.doi.dedup.....c827e45f70beb4727e13bbd25e61b739
Database: OpenAIRE
Description
Abstract:Medullary thyroid carcinoma (MTC) has been shown to express Prospero homeobox protein 1 (Prox1), a transcription factor whose expression is altered in a variety of human cancers. We conducted a retrospective study on a series of 32 patients with MTC to test the correlation of Prox1 expression in MTC with clinicopathological features and to evaluate its prognostic significance. Correlation of Prox1 immunohistochemical expression with tumor size, proliferative index (Ki67), and calcitonin and CEA serum levels prior to surgery was tested for significant correlations. The difference in Prox1 and Ki67 immunohistochemical expression according to the immunohistochemical staining intensity of CEA, chromogranin A, and calcitonin was tested using the Kruskal-Wallis H test and linear regression analysis. The prognostic value of Prox1 and Ki67 for our patient cohort was assessed by Kaplan-Meier log rank survival analysis. We demonstrated a positive correlation between Prox1 expression and Ki67 index. Prox1 also showed significant difference in expression according to chromogranin A and calcitonin immunohistochemical expression, with higher Prox1 expression in tumors with stronger chromogranin A or calcitonin staining. Prox1 expression did not correlate with PFS or OS based on Kaplan-Meier log rank survival analysis. In conclusion, Prox1 expression in MTC is positively correlated with Ki67 and with the immunohistochemical expression of chromogranin A and calcitonin. However, the present study does not support a role for Prox1 in MTC prognosis.
ISSN:15590097
10463976
DOI:10.1007/s12022-019-9576-5