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Distinct Profiles on Subjective and Objective Adherence Measures in Patients Prescribed Antidepressants

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Title: Distinct Profiles on Subjective and Objective Adherence Measures in Patients Prescribed Antidepressants
Authors: Didi Rhebergen, Hans Wouters, Katja Taxis, Helga Gardarsdottir, Antoine C. G. Egberts, Marcia Vervloet, Liset van Dijk
Contributors: Apotheek Onderzoek, Apotheek O&O&O, Lyfjafræðideild (HÍ), Faculty of Pharmaceutical Sciences (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, PECP – Centre for Clinical Therapeutics, PECP - Centre for Pharmacoepidemiology
Source: Drugs
Wouters, H, Rhebergen, D, Vervloet, M, Egberts, A, Taxis, K, van Dijk, L & Gardarsdottir, H 2019, 'Distinct profiles on subjective and objective adherence measures in patients prescribed antidepressants', Drugs, vol. 79, no. 6, pp. 647-654. https://doi.org/10.1007/s40265-019-01107-y
Publisher Information: Springer Science and Business Media LLC, 2019.
Publication Year: 2019
Subject Terms: Adult, Male, Prescription Drugs, Self Report/statistics & numerical data, Pilot Projects, Review, Þunglyndislyf, Sjúklingar, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Journal Article, Humans, Original Research Article, Objective Adherence Measures, Prescription Drugs/pharmacology, Aged, Pharmacies, Assessment of Medication Adherence, Antidepressants, Middle Aged, Geðlyf, Antidepressive Agents, 3. Good health, Antidepressive Agents/pharmacology, Research Design, Medication Adherence/statistics & numerical data, Female, Self Report, Surveys and Questionnaires/statistics & numerical data, Pharmacies/organization & administration
Description: A recurrent observation is that associations between self-reported and objective medication adherence measures are often weak to moderate. Our aim was therefore to identify patients with different profiles on self-reported and objective adherence measures.This was an observational study of 221 community pharmacy patients who were dispensed antidepressants. Adherence profiles were estimated with Latent Profile Analysis (LPA) using data on self-reported adherence (Medication Adherence Rating Scale) complemented with data on medication beliefs (perceived necessity and concerns measured with the Beliefs about Medicines Questionnaire) and data from objective adherence measures (electronic monitoring of medication taking and the Medication Possession Ratio calculated from pharmacy dispensing data).'Goodness-of-fit' statistics indicated the presence of three classes: "concordantly high adherent" (83%, high adherence on all measures), "concordantly suboptimal adherent" (11%, low adherence on all measures), and "discordant" (6%, high self-reported adherence but lower adherence on objective measures).Most patients had concordant outcomes on self-reported and objective measures of adherence. A small discordant class had high self-reported but low objective adherence. LPA will enable sensitivity analyses in future studies, for example excluding patients from the discordant class.
Document Type: Article
Other literature type
File Description: image/pdf
Language: English
ISSN: 1179-1950
0012-6667
DOI: 10.1007/s40265-019-01107-y
Access URL: https://link.springer.com/content/pdf/10.1007/s40265-019-01107-y.pdf
https://pubmed.ncbi.nlm.nih.gov/30941607
https://link.springer.com/content/pdf/10.1007/s40265-019-01107-y.pdf
https://research.vumc.nl/en/publications/distinct-profiles-on-subjective-and-objective-adherence-measures-
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483946/
https://europepmc.org/article/MED/30941607
http://www.rug.nl/research/portal/publications/distinct-profiles-on-subjective-and-objective-adherence-measures-in-patients-prescribed-antidepressants(3306d55d-f153-4051-916c-3532a45804c3).html
https://rd.springer.com/article/10.1007/s40265-019-01107-y
https://research.vumc.nl/en/publications/2416ce4f-cde7-44cb-a0e2-027a97687751
https://dspace.library.uu.nl/handle/1874/391855
https://hdl.handle.net/20.500.11815/2101
https://dspace.library.uu.nl/handle/1874/384915
Rights: CC BY NC
CC BY
Accession Number: edsair.doi.dedup.....c70c0b29c60c8ef709a04f61498c150e
Database: OpenAIRE
Description
Abstract:A recurrent observation is that associations between self-reported and objective medication adherence measures are often weak to moderate. Our aim was therefore to identify patients with different profiles on self-reported and objective adherence measures.This was an observational study of 221 community pharmacy patients who were dispensed antidepressants. Adherence profiles were estimated with Latent Profile Analysis (LPA) using data on self-reported adherence (Medication Adherence Rating Scale) complemented with data on medication beliefs (perceived necessity and concerns measured with the Beliefs about Medicines Questionnaire) and data from objective adherence measures (electronic monitoring of medication taking and the Medication Possession Ratio calculated from pharmacy dispensing data).'Goodness-of-fit' statistics indicated the presence of three classes: "concordantly high adherent" (83%, high adherence on all measures), "concordantly suboptimal adherent" (11%, low adherence on all measures), and "discordant" (6%, high self-reported adherence but lower adherence on objective measures).Most patients had concordant outcomes on self-reported and objective measures of adherence. A small discordant class had high self-reported but low objective adherence. LPA will enable sensitivity analyses in future studies, for example excluding patients from the discordant class.
ISSN:11791950
00126667
DOI:10.1007/s40265-019-01107-y