Sequential Therapy versus Triple Therapy for the First Line Treatment of Helicobacter pylori in Korea: A Nationwide Randomized Trial
Uloženo v:
| Název: | Sequential Therapy versus Triple Therapy for the First Line Treatment of Helicobacter pylori in Korea: A Nationwide Randomized Trial |
|---|---|
| Autoři: | Hyun Joo Song, Su Jin Hong, Sang Wook Kim, Jin Il Kim, Jie Hyun Kim, Joon Sung Kim, Gwang Ho Baik, Ki Nam Shim, Ji Hyun Kim, Byung-Wook Kim |
| Přispěvatelé: | College of Medicine, Dept. of Internal Medicine, Joon Sung Kim, Byung-Wook Kim, Su Jin Hong, Jin Il Kim, Ki-Nam Shim, Jie-Hyun Kim, Gwang Ho Baik, Sang Wook Kim, Hyun Joo Song, Ji Hyun Kim, Kim, Ji Hyun |
| Zdroj: | Gut Liver Gut and Liver, Vol 10, Iss 4, Pp 556-561 (2016) |
| Informace o vydavateli: | The Editorial Office of Gut and Liver, 2016. |
| Rok vydání: | 2016 |
| Témata: | Adult, Male, RC799-869, Drug Administration Schedule, Helicobacter Infections, Medication Adherence, 03 medical and health sciences, 0302 clinical medicine, Anti-Bacterial Agents/administration & dosage, Drug Therapy, Proton Pump Inhibitors/administration & dosage, Clarithromycin, Metronidazole, Republic of Korea, Humans, Aged, drug resistance, Helicobacter pylori, Disease eradication, Amoxicillin, Proton Pump Inhibitors, Diseases of the digestive system. Gastroenterology, Middle Aged, Helicobacter Infections/drug therapy, Clarithromycin/administration & dosage, Anti-Bacterial Agents, Intention to Treat Analysis, 3. Good health, Treatment Outcome, Drug resistance, Amoxicillin/administration & dosage, Combination, Metronidazole/administration & dosage, helicobacter pylori, disease eradication, Original Article, Drug Therapy, Combination, Female, Helicobacter pylori/drug effects |
| Popis: | Eradication of Helicobacter pylori infection with standard triple therapy (TT) has declined primarily because of increased antibiotic resistance. Sequential therapy (ST) has been suggested as an alternative to TT for the first-line treatment of H. pylori. The purpose of this study was to compare the efficacy of ST with TT.This was a multicenter, randomized open-label trial performed at nine centers in Korea. Patients with H. pylori infection were randomly assigned to receive either 7 day TT or 10 day ST. Eradication rates, drug compliance, and adverse events were compared among the two regimens.A total of 601 patients were enrolled between March 2011 and September 2014. The intention-to-treat eradication rates were 70.8% for TT and 82.4% for ST (p=0.001). The corresponding per protocol eradication rates were 76.9% and 88.8% for TT and ST, respectively (p=0.000). There were no statistically significant differences between the two regimens with respect to drug compliance and adverse events.ST achieved better eradication rates than TT as a first-line therapy for H. pylori eradication in Korea. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 2005-1212 1976-2283 |
| DOI: | 10.5009/gnl15470 |
| Přístupová URL adresa: | http://www.gutnliver.org/journal/download_pdf.php?doi=10.5009/gnl15470 https://pubmed.ncbi.nlm.nih.gov/27114421 https://doaj.org/article/8320b0aeae59445b9be24f5d0d1307f3 https://pure.ewha.ac.kr/en/publications/sequential-therapy-versus-triple-therapy-for-the-first-line-treat https://yonsei.pure.elsevier.com/en/publications/sequential-therapy-versus-triple-therapy-for-the-first-line-treat https://dspace.ewha.ac.kr/handle/2015.oak/231748 http://europepmc.org/articles/PMC4933415 https://www.gutnliver.org/journal/view.html?uid=913 https://www.ncbi.nlm.nih.gov/pubmed/27114421 |
| Rights: | CC BY NC CC BY NC ND |
| Přístupové číslo: | edsair.doi.dedup.....c4783e6814c4a906194595332c431bc7 |
| Databáze: | OpenAIRE |
Full Text 
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstrakt: | Eradication of Helicobacter pylori infection with standard triple therapy (TT) has declined primarily because of increased antibiotic resistance. Sequential therapy (ST) has been suggested as an alternative to TT for the first-line treatment of H. pylori. The purpose of this study was to compare the efficacy of ST with TT.This was a multicenter, randomized open-label trial performed at nine centers in Korea. Patients with H. pylori infection were randomly assigned to receive either 7 day TT or 10 day ST. Eradication rates, drug compliance, and adverse events were compared among the two regimens.A total of 601 patients were enrolled between March 2011 and September 2014. The intention-to-treat eradication rates were 70.8% for TT and 82.4% for ST (p=0.001). The corresponding per protocol eradication rates were 76.9% and 88.8% for TT and ST, respectively (p=0.000). There were no statistically significant differences between the two regimens with respect to drug compliance and adverse events.ST achieved better eradication rates than TT as a first-line therapy for H. pylori eradication in Korea. |
|---|---|
| ISSN: | 20051212 19762283 |
| DOI: | 10.5009/gnl15470 |