Case-Control Study: Evaluating the Role and Therapeutic Potential of FSTL1 in Type 2 Inflammation of Chronic Rhinosinusitis
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| Titel: | Case-Control Study: Evaluating the Role and Therapeutic Potential of FSTL1 in Type 2 Inflammation of Chronic Rhinosinusitis |
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| Autoren: | Huang B, Zhu J, Chai X |
| Quelle: | J Inflamm Res Journal of Inflammation Research, Vol Volume 18, Pp 2545-2556 (2025) |
| Verlagsinformationen: | Informa UK Limited, 2025. |
| Publikationsjahr: | 2025 |
| Schlagwörter: | type 2 inflammation, chronic sinusitis, Pathology, RB1-214, follicle suppressor-like protein 1, Therapeutics. Pharmacology, RM1-950, Original Research |
| Beschreibung: | Follicle suppressor-like protein 1 (FSTL1) plays a contributory role in chronic inflammation, and it currently been demonstrated in studies of asthma and chronic obstructive pulmonary disease (COPD), but studies in chronic sinusitis with nasal polyps have not been addressed. The aim of this study was to explore the expression of follicle suppressor-like protein 1 (FSTL1) in chronic sinusitis and its possible association with type 2 inflammation.This study included 34 CRS patients (24 ECRS, 10 non-ECRS) and 10 controls. Hematoxylin-eosin (HE) staining to observe the pathomorphological changes of these three groups of tissue specimens in detail, Immunohistochemistry (IHC), real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) technology and Western blotting (WB) were used to evaluate the expression levels of FSTL1 and type 2 inflammatory cytokines IL-4, IL-5, and IL-13 in the three groups.In the ECRS group, there was thickening of the tissue mucosa and hyperplasia of glands, along with a significant infiltration of inflammatory cells and eosinophils. The experimental results showed that the expression levels of FSTL1 and type 2 inflammatory cytokines IL - 4, IL - 5, and IL - 13 were higher in the ECRS and non - ECRS groups than in the control group (P |
| Publikationsart: | Article Other literature type |
| Sprache: | English |
| ISSN: | 1178-7031 |
| DOI: | 10.2147/jir.s507059 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/39995823 https://doaj.org/article/4d35b9fb7bcc42a8a22e2ca9b4c694d7 |
| Rights: | CC BY NC URL: http://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at http://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (http://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (http://www.dovepress.com/terms.php). |
| Dokumentencode: | edsair.doi.dedup.....c4025bffdde83f2aecf207a4c2e91406 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Follicle suppressor-like protein 1 (FSTL1) plays a contributory role in chronic inflammation, and it currently been demonstrated in studies of asthma and chronic obstructive pulmonary disease (COPD), but studies in chronic sinusitis with nasal polyps have not been addressed. The aim of this study was to explore the expression of follicle suppressor-like protein 1 (FSTL1) in chronic sinusitis and its possible association with type 2 inflammation.This study included 34 CRS patients (24 ECRS, 10 non-ECRS) and 10 controls. Hematoxylin-eosin (HE) staining to observe the pathomorphological changes of these three groups of tissue specimens in detail, Immunohistochemistry (IHC), real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) technology and Western blotting (WB) were used to evaluate the expression levels of FSTL1 and type 2 inflammatory cytokines IL-4, IL-5, and IL-13 in the three groups.In the ECRS group, there was thickening of the tissue mucosa and hyperplasia of glands, along with a significant infiltration of inflammatory cells and eosinophils. The experimental results showed that the expression levels of FSTL1 and type 2 inflammatory cytokines IL - 4, IL - 5, and IL - 13 were higher in the ECRS and non - ECRS groups than in the control group (P |
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| ISSN: | 11787031 |
| DOI: | 10.2147/jir.s507059 |