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An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness

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Title: An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness
Authors: Michael Bauer, Andrea Marfil-Sánchez, Lu Zhang, Yueqiong Ni, Christine Beemelmanns, Pol Alonso-Pernas, Gianni Panagiotou, Bastian Seelbinder, Melinda Mueller, Mohammad Hassan Mirhakkak, Maria Ermolaeva, Anne Busch, Rakesh Santhanam
Source: Gut Microbes
Gut Microbes, Vol 13, Iss 1 (2021)
Gut microbes, 13(1):1993598
Publisher Information: Informa UK Limited, 2021.
Publication Year: 2021
Subject Terms: 0301 basic medicine, Critical Illness, RC799-869, Moths, Infections, intensive care unit, antibiotics, its2, Bile Acids and Salts, 03 medical and health sciences, Drug Resistance, Fungal, critical illness, Animals, Humans, Candida, metagenomics, 0303 health sciences, gut microbiota, Bacteria, Candida/classification, Drug Resistance, Fungal/drug effects [MeSH], Candida/pathogenicity [MeSH], Bile Acids and Salts/metabolism, Bacteria/metabolism [MeSH], Fatty Acids, Volatile/metabolism, Bacteria/drug effects [MeSH], Gastrointestinal Microbiome/drug effects [MeSH], Critical Illness [MeSH], Anti-Bacterial Agents/adverse effects [MeSH], Intensive Care Units [MeSH], Candida/metabolism, Anti-Bacterial Agents/adverse effects, Drug Resistance, Fungal/drug effects, Metabolome/drug effects, Intensive Care Units, Infections/microbiology, Metabolome/drug effects [MeSH], Fatty Acids, Volatile/metabolism [MeSH], Candida/classification [MeSH], Humans [MeSH], Bacteria/metabolism, Candida/drug effects [MeSH], Moths [MeSH], Animals [MeSH], Bacteria/drug effects, Bacteria/classification [MeSH], Bacteria/pathogenicity, Candida/metabolism [MeSH], Bacteria/classification, Bile Acids and Salts/metabolism [MeSH], Candida/pathogenicity, Gastrointestinal Microbiome/drug effects, Infections/microbiology [MeSH], Bacteria/pathogenicity [MeSH], Candida/drug effects, Diseases of the digestive system. Gastroenterology, Fatty Acids, Volatile, metabolomics, Anti-Bacterial Agents, Gastrointestinal Microbiome, 3. Good health, Metabolome, Research Paper
Description: Antibiotics are commonly used in the Intensive Care Unit (ICU); however, several studies showed that the impact of antibiotics to prevent infection, multi-organ failure, and death in the ICU is less clear than their benefit on course of infection in the absence of organ dysfunction. We characterized here the compositional and metabolic changes of the gut microbiome induced by critical illness and antibiotics in a cohort of 75 individuals in conjunction with 2,180 gut microbiome samples representing 16 different diseases. We revealed an "infection-vulnerable" gut microbiome environment present only in critically ill treated with antibiotics (ICU+). Feeding of Caenorhabditis elegans with Bifidobacterium animalis and Lactobacillus crispatus, species that expanded in ICU+ patients, revealed a significant negative impact of these microbes on host viability and developmental homeostasis. These results suggest that antibiotic administration can dramatically impact essential functional activities in the gut related to immune responses more than critical illness itself, which might explain in part untoward effects of antibiotics in the critically ill.
Document Type: Article
Other literature type
Language: English
ISSN: 1949-0984
1949-0976
DOI: 10.1080/19490976.2021.1993598
Access URL: https://www.tandfonline.com/doi/pdf/10.1080/19490976.2021.1993598?needAccess=true
https://pubmed.ncbi.nlm.nih.gov/34793277
https://doaj.org/article/aa87bc94a1fb48ea8392831d68f0aae0
https://pubmed.ncbi.nlm.nih.gov/34793277/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604395
https://repository.publisso.de/resource/frl:6475631
Rights: CC BY NC
URL: http://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Accession Number: edsair.doi.dedup.....c3b38f16d460a7bd57563d31fe7d8e46
Database: OpenAIRE
Description
Abstract:Antibiotics are commonly used in the Intensive Care Unit (ICU); however, several studies showed that the impact of antibiotics to prevent infection, multi-organ failure, and death in the ICU is less clear than their benefit on course of infection in the absence of organ dysfunction. We characterized here the compositional and metabolic changes of the gut microbiome induced by critical illness and antibiotics in a cohort of 75 individuals in conjunction with 2,180 gut microbiome samples representing 16 different diseases. We revealed an "infection-vulnerable" gut microbiome environment present only in critically ill treated with antibiotics (ICU+). Feeding of Caenorhabditis elegans with Bifidobacterium animalis and Lactobacillus crispatus, species that expanded in ICU+ patients, revealed a significant negative impact of these microbes on host viability and developmental homeostasis. These results suggest that antibiotic administration can dramatically impact essential functional activities in the gut related to immune responses more than critical illness itself, which might explain in part untoward effects of antibiotics in the critically ill.
ISSN:19490984
19490976
DOI:10.1080/19490976.2021.1993598