A new antibiotic regimen treats and prevents intra-amniotic inflammation/infection in patients with preterm PROM
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| Název: | A new antibiotic regimen treats and prevents intra-amniotic inflammation/infection in patients with preterm PROM |
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| Autoři: | Piya Chaemsaithong, Bo Hyun Yoon, JoonHo Lee, Sun Min Kim, Roberto Romero |
| Přispěvatelé: | College of Medicine, Dept. of Obstetrics & Gynecology, JoonHo Lee, Roberto Romero, Sun Min Kim, Piya Chaemsaithong, Bo Hyun Yoon, Lee, Joon Ho |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 29:2727-2737 |
| Informace o vydavateli: | Informa UK Limited, 2015. |
| Rok vydání: | 2015 |
| Témata: | placental pathology, preterm labor, Adult, Fetal Membranes, Premature Rupture, neonatal sepsis, Young Adult, 03 medical and health sciences, metronidazole, 0302 clinical medicine, Anti-Bacterial Agents/administration & dosage, Drug Therapy, funisitis, Pregnancy, Clarithromycin, Metronidazole, Humans, Fetal Membranes, Premature Rupture, Retrospective Studies, Antibiotic Prophylaxis, 4. Education, prematurity, Ceftriaxone, preterm birth, neonatal morbidity, clarithromycin, Clarithromycin/administration & dosage, chorioamnionitis, Anti-Bacterial Agents, 3. Good health, Chorioamnionitis, Ceftriaxone/administration & dosage, erythromycin, Combination, Metronidazole/administration & dosage, Drug Therapy, Combination, Female, Chorioamnionitis/microbiology, Chorioamnionitis/prevention & control |
| Popis: | To determine whether a new antibiotic regimen could reduce the frequency of intra-amniotic inflammation/infection in patients with preterm PROM.This retrospective cohort study was conducted to evaluate the effect of antibiotics on the frequency of intra-amniotic inflammation/infection based on the results of follow-up transabdominal amniocenteses from 89 patients diagnosed with preterm PROM who underwent serial amniocenteses. From 1993-2003, ampicillin and/or cephalosporins or a combination was used ("regimen 1"). A new regimen (ceftriaxone, clarithromycin and metronidazole) was used from 2003-2012 ("regimen 2"). Amniotic fluid was cultured and matrix metalloproteinase-8 (MMP-8) concentrations were measured.(1) The rates of intra-amniotic inflammation and intra-amniotic inflammation/infection in patients who received regimen 2 decreased during treatment from 68.8% to 52.1% and from 75% to 54.2%, respectively. In contrast, in patients who received regimen 1, the frequency of intra-amniotic inflammation and infection/inflammation increased during treatment (31.7% to 55% and 34.1% to 58.5%, respectively); and (2) intra-amniotic inflammation/infection was eradicated in 33.3% of patients who received regimen 2, but in none who received regimen 1.The administration of ceftriaxone, clarithromycin and metronidazole was associated with a more successful eradication of intra-amniotic inflammation/infection and prevented secondary intra-amniotic inflammation/infection more frequently than an antibiotic regimen which included ampicillin and/or cephalosporins in patients with preterm PROM. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.3109/14767058.2015.1103729 |
| Přístupová URL adresa: | https://www.tandfonline.com/doi/pdf/10.3109/14767058.2015.1103729?needAccess=true https://pubmed.ncbi.nlm.nih.gov/26441216 https://europepmc.org/article/MED/26441216 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703065/ https://pubmed.ncbi.nlm.nih.gov/26441216/ https://www.tandfonline.com/doi/full/10.3109/14767058.2015.1103729 https://yonsei.pure.elsevier.com/en/publications/a-new-antibiotic-regimen-treats-and-prevents-intra-amniotic-infla https://snucm.elsevierpure.com/en/publications/a-new-antibiotic-regimen-treats-and-prevents-intra-amniotic-infla |
| Rights: | CC BY NC ND |
| Přístupové číslo: | edsair.doi.dedup.....c2ed6518c91aa31dd3d55d8044078166 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | To determine whether a new antibiotic regimen could reduce the frequency of intra-amniotic inflammation/infection in patients with preterm PROM.This retrospective cohort study was conducted to evaluate the effect of antibiotics on the frequency of intra-amniotic inflammation/infection based on the results of follow-up transabdominal amniocenteses from 89 patients diagnosed with preterm PROM who underwent serial amniocenteses. From 1993-2003, ampicillin and/or cephalosporins or a combination was used ("regimen 1"). A new regimen (ceftriaxone, clarithromycin and metronidazole) was used from 2003-2012 ("regimen 2"). Amniotic fluid was cultured and matrix metalloproteinase-8 (MMP-8) concentrations were measured.(1) The rates of intra-amniotic inflammation and intra-amniotic inflammation/infection in patients who received regimen 2 decreased during treatment from 68.8% to 52.1% and from 75% to 54.2%, respectively. In contrast, in patients who received regimen 1, the frequency of intra-amniotic inflammation and infection/inflammation increased during treatment (31.7% to 55% and 34.1% to 58.5%, respectively); and (2) intra-amniotic inflammation/infection was eradicated in 33.3% of patients who received regimen 2, but in none who received regimen 1.The administration of ceftriaxone, clarithromycin and metronidazole was associated with a more successful eradication of intra-amniotic inflammation/infection and prevented secondary intra-amniotic inflammation/infection more frequently than an antibiotic regimen which included ampicillin and/or cephalosporins in patients with preterm PROM. |
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| ISSN: | 14764954 14767058 |
| DOI: | 10.3109/14767058.2015.1103729 |