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Ultrahigh Resolution fMRI at 7T Using Radial‐Cartesian TURBINE Sampling

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Title: Ultrahigh Resolution fMRI at 7T Using Radial‐Cartesian TURBINE Sampling
Authors: Nadine N. Graedel, Karla L. Miller, Mark Chiew
Source: Magn Reson Med
Publisher Information: Wiley, 2022.
Publication Year: 2022
Subject Terms: Brain Mapping, high-resolution fMRI, 7T, Echo-Planar Imaging, fMRI, Brain, TURBINE, Magnetic Resonance Imaging, Image Processing, Computer-Assisted, radial-Cartesian, ultrahigh-field MRI, Anisotropy, Research Articles–Imaging Methodology, Algorithms
Description: PurposeWe investigate the use of TURBINE, a 3D radial‐Cartesian acquisition scheme in which EPI planes are rotated about the phase‐encoding axis to acquire a cylindrical k‐space for high‐fidelity ultrahigh isotropic resolution fMRI at 7 Tesla with minimal distortion and blurring.MethodsAn improved, completely self‐navigated version of the TURBINE sampling scheme was designed for fMRI at 7 Telsa. To demonstrate the image quality and spatial specificity of the acquisition, thin‐slab visual and motor BOLD fMRI at 0.67 mm isotropic resolution (16 mm slab, TRvol = 2.32 s), and 0.8 × 0.8 × 2.0 mm (whole‐brain, TRvol = 2.4 s) data were acquired. To prioritize the high spatial fidelity, we employed a temporally regularized reconstruction to improve sensitivity without any spatial bias.ResultsTURBINE images provide high structural fidelity with almost no distortion, dropout, or T2* blurring for the thin‐slab acquisitions compared to conventional 3D EPI owing to the radial sampling in‐plane and the short echo train used. This results in activation that can be localized to pre‐ and postcentral gyri in a motor task, for example, with excellent correspondence to brain structure measured by a T1‐MPRAGE. The benefits of TURBINE (low distortion, dropout, blurring) are reduced for the whole‐brain acquisition due to the longer EPI train. We demonstrate robust BOLD activation at 0.67 mm isotropic resolution (thin‐slab) and also anisotropic 0.8 × 0.8 × 2.0 mm (whole‐brain) acquisitions.ConclusionTURBINE is a promising acquisition approach for high‐resolution, minimally distorted fMRI at 7 Tesla and could be particularly useful for fMRI in areas of high B0 inhomogeneity.
Document Type: Article
Other literature type
Language: English
ISSN: 1522-2594
0740-3194
DOI: 10.1002/mrm.29359
Access URL: https://pubmed.ncbi.nlm.nih.gov/35785429
https://discovery-pp.ucl.ac.uk/id/eprint/10151968/
Rights: CC BY
Accession Number: edsair.doi.dedup.....c2bcfd572f69603a8368d04d72d672af
Database: OpenAIRE
Description
Abstract:PurposeWe investigate the use of TURBINE, a 3D radial‐Cartesian acquisition scheme in which EPI planes are rotated about the phase‐encoding axis to acquire a cylindrical k‐space for high‐fidelity ultrahigh isotropic resolution fMRI at 7 Tesla with minimal distortion and blurring.MethodsAn improved, completely self‐navigated version of the TURBINE sampling scheme was designed for fMRI at 7 Telsa. To demonstrate the image quality and spatial specificity of the acquisition, thin‐slab visual and motor BOLD fMRI at 0.67 mm isotropic resolution (16 mm slab, TRvol = 2.32 s), and 0.8 × 0.8 × 2.0 mm (whole‐brain, TRvol = 2.4 s) data were acquired. To prioritize the high spatial fidelity, we employed a temporally regularized reconstruction to improve sensitivity without any spatial bias.ResultsTURBINE images provide high structural fidelity with almost no distortion, dropout, or T2* blurring for the thin‐slab acquisitions compared to conventional 3D EPI owing to the radial sampling in‐plane and the short echo train used. This results in activation that can be localized to pre‐ and postcentral gyri in a motor task, for example, with excellent correspondence to brain structure measured by a T1‐MPRAGE. The benefits of TURBINE (low distortion, dropout, blurring) are reduced for the whole‐brain acquisition due to the longer EPI train. We demonstrate robust BOLD activation at 0.67 mm isotropic resolution (thin‐slab) and also anisotropic 0.8 × 0.8 × 2.0 mm (whole‐brain) acquisitions.ConclusionTURBINE is a promising acquisition approach for high‐resolution, minimally distorted fMRI at 7 Tesla and could be particularly useful for fMRI in areas of high B0 inhomogeneity.
ISSN:15222594
07403194
DOI:10.1002/mrm.29359