Volatile versus propofol sedation after cardiac valve surgery: a single-center prospective randomized controlled trial
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| Title: | Volatile versus propofol sedation after cardiac valve surgery: a single-center prospective randomized controlled trial |
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| Authors: | Flinspach, Armin Niklas, Raimann, Florian Jürgen, Kaiser, Philipp, Pfaff, Michaela, Zacharowski, Kai, Neef, Vanessa, Adam, Elisabeth Hannah |
| Source: | Crit Care |
| Publisher Information: | Springer Science and Business Media LLC, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | 03 medical and health sciences, 0302 clinical medicine, Critical Care, Research, Airway Extubation, Humans, Hypnotics and Sedatives, Cardiac Valve Prosthesis, Critical care, Hypnotics and Sedatives/therapeutic use [MeSH], Humans [MeSH], Prospective Studies [MeSH], Airway Extubation [MeSH], Propofol/therapeutic use [MeSH], Critical Care/methods [MeSH], Volatile sedation, Cardiac Surgical Procedures/methods [MeSH], Management, Cardiac surgery, Awakening, Prospective Studies, Cardiac Surgical Procedures, Propofol |
| Description: | Background Optimal intensive care of patients undergoing valve surgery is a complex balancing act between sedation for monitoring and timely postoperative awakening. It remains unclear, if these requirements can be fulfilled by volatile sedations in intensive care medicine in an efficient manner. Therefore, this study aimed to assess the time to extubation and secondary the workload required. Methods We conducted a prospective randomized single-center trial at a tertiary university hospital to evaluate the postoperative management of open valve surgery patients. The study was randomized with regard to the use of volatile sedation compared to propofol sedation. Sedation was discontinued 60 min after admission for critical postoperative monitoring. Results We observed a significantly earlier extubation (91 ± 39 min vs. 167 ± 77 min; p p p p = 0.36. Conclusions Using volatile sedation is associated with few minutes additional workload in assembling and enables a significantly accelerated evaluation of vulnerable patient groups. Volatile sedation has considerable advantages and emerges as a safe sedation technique in our vulnerable study population. Trial registration: Clinical trials registration (NCT04958668) was completed on 1 July 2021. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1364-8535 |
| DOI: | 10.1186/s13054-024-04899-y |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/38581030 https://repository.publisso.de/resource/frl:6493308 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| Accession Number: | edsair.doi.dedup.....c0b103cabe6d80ab0d57365af4e0a590 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Background Optimal intensive care of patients undergoing valve surgery is a complex balancing act between sedation for monitoring and timely postoperative awakening. It remains unclear, if these requirements can be fulfilled by volatile sedations in intensive care medicine in an efficient manner. Therefore, this study aimed to assess the time to extubation and secondary the workload required. Methods We conducted a prospective randomized single-center trial at a tertiary university hospital to evaluate the postoperative management of open valve surgery patients. The study was randomized with regard to the use of volatile sedation compared to propofol sedation. Sedation was discontinued 60 min after admission for critical postoperative monitoring. Results We observed a significantly earlier extubation (91 ± 39 min vs. 167 ± 77 min; p p p p = 0.36. Conclusions Using volatile sedation is associated with few minutes additional workload in assembling and enables a significantly accelerated evaluation of vulnerable patient groups. Volatile sedation has considerable advantages and emerges as a safe sedation technique in our vulnerable study population. Trial registration: Clinical trials registration (NCT04958668) was completed on 1 July 2021. |
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| ISSN: | 13648535 |
| DOI: | 10.1186/s13054-024-04899-y |