Fast and reproducible in vivo T1 mapping of the human cervical spinal cord
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| Název: | Fast and reproducible in vivo T1 mapping of the human cervical spinal cord |
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| Autoři: | Rebecca S. Samson, Francesco Grussu, Marco Battiston, Torben Schneider, Claudia A. M. Wheeler-Kingshott, Sebastien Ourselin, Marios C. Yiannakas, Ferran Prados |
| Přispěvatelé: | Battiston, M, Schneider, T, Prados, F, Grussu, F, Yiannakas, Mc, Ourselin, S, Gandini, C., Samson, Rs |
| Zdroj: | Magnetic Resonance in Medicine |
| Informace o vydavateli: | Wiley, 2017. |
| Rok vydání: | 2017 |
| Témata: | Adult, Male, Motion, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, Image Interpretation, Computer-Assisted, Humans, reproducibility, T mapping, Echo-Planar Imaging, Phantoms, Imaging, spinal cord, Brain, Cervical Cord, Reproducibility of Results, T-1 mapping, Signal Processing, Computer-Assisted, T1 mapping, Healthy Volunteers, 3. Good health, Female, inversion Recovery, reduced FOV, Algorithms |
| Popis: | PurposeTo develop a fast and robust method for measuring T1 in the whole cervical spinal cord in vivo, and to assess its reproducibility.MethodsA spatially nonselective adiabatic inversion pulse is combined with zonally oblique‐magnified multislice echo‐planar imaging to produce a reduced field‐of‐view inversion‐recovery echo‐planar imaging protocol. Multi‐ inversion time data are obtained by cycling slice order throughout sequence repetitions. Measurement of T1 is performed using 12 inversion times for a total protocol duration of 7 min. Reproducibility of regional T1 estimates is assessed in a scan‐rescan experiment on five heathy subjects.ResultsRegional mean (standard deviation) T1 was: 1108.5 (±77.2) ms for left lateral column, 1110.1 (±83.2) ms for right lateral column, 1150.4 (±102.6) ms for dorsal column, and 1136.4 (±90.8) ms for gray matter. Regional T1 estimates showed good correlation between sessions (Pearson correlation coefficient = 0.89 (P value P value ConclusionsT1 estimates in the cervical spinal cord are reproducible using inversion‐recovery zonally oblique‐magnified multislice echo‐planar imaging. The short acquisition time and large coverage of this method paves the way for accurate T1 mapping for various spinal cord pathologies. Magn Reson Med 79:2142–2148, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Druh dokumentu: | Article |
| Popis souboru: | STAMPA |
| Jazyk: | English |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.26852 |
| Přístupová URL adresa: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mrm.26852 https://pubmed.ncbi.nlm.nih.gov/28736946 https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.26852 http://discovery.ucl.ac.uk/1567633/ https://www.ncbi.nlm.nih.gov/pubmed/28736946 https://core.ac.uk/display/111027506 https://discovery-pp.ucl.ac.uk/id/eprint/1567633/ |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....c05f8891e4581cbbde1c85ca9ba342a1 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | PurposeTo develop a fast and robust method for measuring T1 in the whole cervical spinal cord in vivo, and to assess its reproducibility.MethodsA spatially nonselective adiabatic inversion pulse is combined with zonally oblique‐magnified multislice echo‐planar imaging to produce a reduced field‐of‐view inversion‐recovery echo‐planar imaging protocol. Multi‐ inversion time data are obtained by cycling slice order throughout sequence repetitions. Measurement of T1 is performed using 12 inversion times for a total protocol duration of 7 min. Reproducibility of regional T1 estimates is assessed in a scan‐rescan experiment on five heathy subjects.ResultsRegional mean (standard deviation) T1 was: 1108.5 (±77.2) ms for left lateral column, 1110.1 (±83.2) ms for right lateral column, 1150.4 (±102.6) ms for dorsal column, and 1136.4 (±90.8) ms for gray matter. Regional T1 estimates showed good correlation between sessions (Pearson correlation coefficient = 0.89 (P value P value ConclusionsT1 estimates in the cervical spinal cord are reproducible using inversion‐recovery zonally oblique‐magnified multislice echo‐planar imaging. The short acquisition time and large coverage of this method paves the way for accurate T1 mapping for various spinal cord pathologies. Magn Reson Med 79:2142–2148, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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| ISSN: | 15222594 07403194 |
| DOI: | 10.1002/mrm.26852 |