ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice
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| Title: | ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice |
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| Authors: | Zhong Peng, Panos G. Ziros, Tomaz Martini, Xiao-Hui Liao, Ron Stoop, Samuel Refetoff, Urs Albrecht, Gerasimos P. Sykiotis, Stephan Kellenberger |
| Source: | Commun Biol Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023) Communications biology, vol. 6, no. 1, pp. 857 |
| Publisher Information: | Springer Science and Business Media LLC, 2023. |
| Publication Year: | 2023 |
| Subject Terms: | Acid Sensing Ion Channels, Animals, Mice, Acid Sensing Ion Channels/genetics, Body Temperature, Energy Metabolism/genetics, Hypothalamus, RNA, Messenger, QH301-705.5, Biology (General), Energy Metabolism, Article |
| Description: | The body temperature of mice is higher at night than during the day. We show here that global deletion of acid-sensing ion channel 1a (ASIC1a) results in lower body temperature during a part of the night. ASICs are pH sensors that modulate neuronal activity. The deletion of ASIC1a decreased the voluntary activity at night of mice that had access to a running wheel but did not affect their spontaneous activity. Daily rhythms of thyrotropin-releasing hormone mRNA in the hypothalamus and of thyroid-stimulating hormone β mRNA in the pituitary, and of prolactin mRNA in the hypothalamus and pituitary were suppressed in ASIC1a−/− mice. The serum thyroid hormone levels were however not significantly changed by ASIC1a deletion. Our findings indicate that ASIC1a regulates activity and signaling in the hypothalamus and pituitary. This likely leads to the observed changes in body temperature by affecting the metabolism or energy expenditure. |
| Document Type: | Article Conference object Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-023-05221-2 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/37591947 https://doaj.org/article/1a56f049de1e49678db476469c0d0a2b https://serval.unil.ch/resource/serval:BIB_B248EF4DD49B.P001/REF.pdf https://serval.unil.ch/notice/serval:BIB_B248EF4DD49B http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_B248EF4DD49B3 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....bf59faa29ad7a3c7dbd7ae187921d7dc |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | The body temperature of mice is higher at night than during the day. We show here that global deletion of acid-sensing ion channel 1a (ASIC1a) results in lower body temperature during a part of the night. ASICs are pH sensors that modulate neuronal activity. The deletion of ASIC1a decreased the voluntary activity at night of mice that had access to a running wheel but did not affect their spontaneous activity. Daily rhythms of thyrotropin-releasing hormone mRNA in the hypothalamus and of thyroid-stimulating hormone β mRNA in the pituitary, and of prolactin mRNA in the hypothalamus and pituitary were suppressed in ASIC1a−/− mice. The serum thyroid hormone levels were however not significantly changed by ASIC1a deletion. Our findings indicate that ASIC1a regulates activity and signaling in the hypothalamus and pituitary. This likely leads to the observed changes in body temperature by affecting the metabolism or energy expenditure. |
|---|---|
| ISSN: | 23993642 |
| DOI: | 10.1038/s42003-023-05221-2 |