Preparation and characterization of naproxen-loaded electrospun thermoplastic polyurethane nanofibers as a drug delivery system
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| Titel: | Preparation and characterization of naproxen-loaded electrospun thermoplastic polyurethane nanofibers as a drug delivery system |
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| Autoren: | Akduman, Çiğdem, Özgüney, I., Kumbasar, E.P.A. |
| Quelle: | Materials Science and Engineering: C. 64:383-390 |
| Verlagsinformationen: | Elsevier BV, 2016. |
| Publikationsjahr: | 2016 |
| Schlagwörter: | Phosphate buffer solutions, Drug delivery system, Polyurethanes, Nanofibers, Thermoplastic polyurethane, Release characteristics, Average diameter, 02 engineering and technology, chemistry, 01 natural sciences, Drug Delivery Systems/*methods, Nanofibers/*chemistry, Naproxen/chemistry/pharmacokinetics, Polyurethanes/chemistry/pharmacokinetics, Drug Delivery Systems, Naproxen, naproxen, drug delivery system, procedures, nanofiber, Electrospinning, polyurethan, Spinning (fibers), Drug release, 0104 chemical sciences, 3. Good health, Fibers, Thermoplastic polyurethanes, Reinforced plastics, Ultra-fine fibers, Naproxens, 0210 nano-technology, Plastics |
| Beschreibung: | The design and production of drug-loaded nanofiber based materials produced by electrospinning is of interest for use in innovative drug delivery systems. In the present study, ultra-fine fiber mats of thermoplastic polyurethane (TPU) containing naproxen (NAP) were successfully prepared by electrospinning from 8 and 10% (w/w) TPU solutions. The amount of NAP in the solutions was 10 and 20% based on the weight of TPU. The collection period of the drug-loaded electrospun TPU fibers was 5, 10 and 20h, and they were characterized by FTIR, DSC and TGA analysis. The morphology of the NAP-loaded electrospun TPU fiber mats was smooth, and the average diameters of these fibers varied between 523.66 and 723.50nm. The release characteristics of these fiber mats were determined by the total immersion method in the phosphate buffer solution at 37°C. It was observed that the collection period in terms of the mat thickness played a major role in the release rate of NAP from the electrospun TPU mats. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2016.04.005 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/27127068 https://europepmc.org/abstract/MED/27127068 https://avesis.ege.edu.tr/yayin/5a9b1ad8-52d4-47ff-befa-a952c978cd58/preparation-and-characterization-of-naproxen-loaded-electrospun-thermoplastic-polyurethane-nanofibers-as-a-drug-delivery-system https://pubmed.ncbi.nlm.nih.gov/27127068/ https://www.ncbi.nlm.nih.gov/pubmed/27127068 https://www.sciencedirect.com/science/article/pii/S0928493116303034 https://www.infona.pl/resource/bwmeta1.element.elsevier-cd2ed8c2-c937-37bd-8019-059f6b61a761 https://hdl.handle.net/11499/9524 https://doi.org/10.1016/j.msec.2016.04.005 http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/9524 https://hdl.handle.net/11454/52643 https://doi.org/10.1016/j.msec.2016.04.005 |
| Rights: | Elsevier TDM |
| Dokumentencode: | edsair.doi.dedup.....bf1d176d8c57156bfd4748ae7f308b9b |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | The design and production of drug-loaded nanofiber based materials produced by electrospinning is of interest for use in innovative drug delivery systems. In the present study, ultra-fine fiber mats of thermoplastic polyurethane (TPU) containing naproxen (NAP) were successfully prepared by electrospinning from 8 and 10% (w/w) TPU solutions. The amount of NAP in the solutions was 10 and 20% based on the weight of TPU. The collection period of the drug-loaded electrospun TPU fibers was 5, 10 and 20h, and they were characterized by FTIR, DSC and TGA analysis. The morphology of the NAP-loaded electrospun TPU fiber mats was smooth, and the average diameters of these fibers varied between 523.66 and 723.50nm. The release characteristics of these fiber mats were determined by the total immersion method in the phosphate buffer solution at 37°C. It was observed that the collection period in terms of the mat thickness played a major role in the release rate of NAP from the electrospun TPU mats. |
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| ISSN: | 09284931 |
| DOI: | 10.1016/j.msec.2016.04.005 |