Hopelessness in Patients with Early-Stage Relapsing-Remitting Multiple Sclerosis
Saved in:
| Title: | Hopelessness in Patients with Early-Stage Relapsing-Remitting Multiple Sclerosis |
|---|---|
| Authors: | Susana Sainz de la Maza, Jorge Maurino, Tamara Castillo-Triviño, Mónica Borges, Berta Sebastián Torres, Javier Sotoca, Ana María Alonso Torres, Ana B Caminero, Laura Borrega, José L Sánchez-Menoyo, Francisco J Barrero-Hernández, Carmen Calles, Luis Brieva, María Rosario Blasco, Julio Dotor García-Soto, Ana Rodríguez-Regal, Laura Navarro-Cantó, Eduardo Agüera-Morales, Moisés Garcés, Olga Carmona, Laura Gabaldón-Torres, Lucía Forero, Mariona Hervás, Rocío Gómez-Ballesteros |
| Contributors: | Institut Català de la Salut, [Sainz de la Maza S] Department of Neurology, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Maurino J] Medical Department, Roche Farma, Madrid, Spain. [Castillo-Triviño T] Department of Neurology, Hospital Universitario Donostia, San Sebastián, Spain. [Borges M] Department of Neurology, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Sebastián Torres B] Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain. [Sotoca J] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona |
| Source: | Patient Prefer Adherence Scientia Scientia. Dipòsit d'Informació Digital del Departament de Salut instname Digibug. Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Docusalut Conselleria de Salut i Consum del Govern de les Illes Balears Zaguán. Repositorio Digital de la Universidad de Zaragoza Universidad de Zaragoza Patient Preference and Adherence, Vol Volume 17, Pp 1431-1439 (2023) |
| Publisher Information: | Informa UK Limited, 2023. |
| Publication Year: | 2023 |
| Subject Terms: | Workplace difficulties, Medicine (General), Esclerosis Múltiple Recurrente-Remitente, PSYCHIATRY AND PSYCHOLOGY::Behavioral Disciplines and Activities::Psychological Tests, Esclerosi múltiple, relapsing-remitting multiple sclerosis, DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis, Lugar de Trabajo, PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::conducta::síntomas conductuales::depresión, Multiple Sclerosis, Relapsing-Remitting, R5-920, depressive symptoms, hopelessness, Suicidio, PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::emociones::afecto, Workplace, Afecte (Psicologia), PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Emotions::Affect, suicide, Original Research, Depressive Disorder, Depressive symptoms, workplace difficulties, Tests psicològics, 3. Good health, Suicide, Patient Preference and Adherence, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple, PSIQUIATRÍA Y PSICOLOGÍA::disciplinas y actividades conductuales::pruebas psicológicas, Hopelessness, Relapsing-remitting multiple sclerosis, PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression, Trastorno Depresivo |
| Description: | Hopelessness is a risk factor for depression and suicide. There is little information on this phenomenon among patients with relapsing-remitting multiple sclerosis (RRMS), one of the most common causes of disability and loss of autonomy in young adults. The aim of this study was to assess state hopelessness and its associated factors in early-stage RRMS.A multicenter, non-interventional study was conducted. Adult patients with a diagnosis of RRMS, a disease duration ≤ 3 years, and an Expanded Disability Status Scale (EDSS) score of 0-5.5 were included. The State-Trait Hopelessness Scale (STHS) was used to measure patients´ hopelessness. A battery of patient-reported and clinician-rated measurements was used to assess clinical status. A multivariate logistic regression analysis was conducted to determine the association between patients' characteristics and state hopelessness.A total of 189 patients were included. Mean age (standard deviation-SD) was 36.1 (9.4) years and 71.4% were female. Median disease duration (interquartile range-IQR) was 1.4 (0.7, 2.1) years. Symptom severity and disability were low with a median EDSS (IQR) score of 1.0 (0, 2.0). A proportion of 65.6% (n=124) of patients reported moderate-to-severe hopelessness. Hopelessness was associated with older age (p=0.035), depressive symptoms (p= |
| Document Type: | Article Other literature type |
| File Description: | application/pdf; text/html |
| Language: | English |
| ISSN: | 1177-889X |
| DOI: | 10.2147/ppa.s411069 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/37337517 https://hdl.handle.net/11351/9882 https://hdl.handle.net/20.500.12530/109730 https://hdl.handle.net/20.500.12530/117755 https://hdl.handle.net/20.500.13003/21362 http://zaguan.unizar.es/record/131811 https://hdl.handle.net/20.500.12530/93921 https://doaj.org/article/b0ad8b55bdea4a38ac4467bab01ae68d https://www.dovepress.com/hopelessness-in-patients-with-early-stage-relapsing-remitting-multiple-peer-reviewed-fulltext-article-PPA https://hdl.handle.net/20.500.13003/25435 https://hdl.handle.net/10481/92906 |
| Rights: | CC BY NC CC BY NC ND CC BY URL: http://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at http://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (http://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (http://www.dovepress.com/terms.php). |
| Accession Number: | edsair.doi.dedup.....bedf4f79e5578bb9f46f798271c29e7b |
| Database: | OpenAIRE |
Full Text 
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstract: | Hopelessness is a risk factor for depression and suicide. There is little information on this phenomenon among patients with relapsing-remitting multiple sclerosis (RRMS), one of the most common causes of disability and loss of autonomy in young adults. The aim of this study was to assess state hopelessness and its associated factors in early-stage RRMS.A multicenter, non-interventional study was conducted. Adult patients with a diagnosis of RRMS, a disease duration ≤ 3 years, and an Expanded Disability Status Scale (EDSS) score of 0-5.5 were included. The State-Trait Hopelessness Scale (STHS) was used to measure patients´ hopelessness. A battery of patient-reported and clinician-rated measurements was used to assess clinical status. A multivariate logistic regression analysis was conducted to determine the association between patients' characteristics and state hopelessness.A total of 189 patients were included. Mean age (standard deviation-SD) was 36.1 (9.4) years and 71.4% were female. Median disease duration (interquartile range-IQR) was 1.4 (0.7, 2.1) years. Symptom severity and disability were low with a median EDSS (IQR) score of 1.0 (0, 2.0). A proportion of 65.6% (n=124) of patients reported moderate-to-severe hopelessness. Hopelessness was associated with older age (p=0.035), depressive symptoms (p= |
|---|---|
| ISSN: | 1177889X |
| DOI: | 10.2147/ppa.s411069 |