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LONG-TERM EFFECTS OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION AMONG SURVIVORS AT UNIVERSITY HOSPITAL CENTRE ZAGREB

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Bibliographic Details
Title: LONG-TERM EFFECTS OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION AMONG SURVIVORS AT UNIVERSITY HOSPITAL CENTRE ZAGREB
Authors: Duraković, Nadira, Desnica, Lana, Vrhovac, Radovan, Samardžić, Antonela, Perić, Zinaida, Serventi-Seiwerth, Ranka
Source: Liječnički vjesnik
CODEN LIVJA5
Volume 141
Issue 5-6
Publisher Information: Croatian Medical Association, 2019.
Publication Year: 2019
Subject Terms: Homologous, VREMENSKI ČIMBENICI, transplantacija krvotvornih matičnih stanica, Long Term Adverse Effects, NEOPLASMS, SECOND PRIMARY – epidemiology, etiology, TRANSPLANTACIJA KRVOTVORNIH MATIČNIH STANICA – neželjeni učinci, statistički podatci, RETROSPEKTIVNE STUDIJE, ENDOKRINE BOLESTI – epidemiologija, etiologija, TRANSPLANTATION, HOMOLOGOUS, QUALITY OF LIFE, Cancer Survivors, KRONIČNA BOLEST, RETROSPECTIVE STUDIES, KARDIOVASKULARNE BOLESTI – epidemiologija, etiologija, Bone Marrow Transplantation, HEMATOPOIETIC STEM CELL TRANSPLANTATION – adverse effects, statistics and numerical data, SURVIVORS, 2. Zero hunger, Transplantation, TIME FACTORS, transplantacija krvotvornih matičnih stanica, transplantacija koštane srži, alogena transplantacija, dugoročni negativni učinci, dugoročno preživljenje, dugoročni negativni učinci, transplantacija koštane srži, Hematopoietic Stem Cell Transplantation, PREŽIVJELI, alogena transplantacija, 3. Good health, ENDOCRINE SYSTEM DISEASES – epidemiology, etiology, BOLEST PRESATKA PROTIV PRIMATELJA – epidemiologija, etiologija, SEKUNDARNI TUMORI – epidemiologija, etiologija, CHRONIC DISEASE, dugoročno preživljenje, KVALITETA ŽIVOTA, CARDIOVASCULAR DISEASES – epidemiology, etiology, GRAFT VS HOST DISEASE – epidemiology, etiology, ALOGENA TRANSPLANTACIJA
Description: The number of long-term survivors after allogeneic hematopoietic stem cell transplantation is increasing daily, and late effects of such treatment cause significant quality of life impairment. We analysed the data of 111 long-term survivors that were transplanted at the University Hospital Centre Zagreb in the period between 1986 and 2009. For the investigated population survival median time was 15 years (range 2–33). Our results were similar to those reported by other researchers, and have shown a rising trend over a longer follow-up period. The cumulative incidence of cardiovascular and endocrine complications, solid tumors, chronic graft versus host disease (GvHD), liver, renal and pulmonary diseases is 64%, 42%, 33%, 32%, 28%, 17% and 14%, respectively. Further analysis confirmed that the spontaneous recovery of menstrual cycle was more likely among patiens transplanted in childhood than in adulthood (45% vs 18%). Premature ovarian insufficiency (POI) was detected in 71% of female patients transplanted in adult age. However, five women gave birth to six healthy children in this study population, where two pregnancies occurred after spontaneous recovery of ovarian function, one after the use of hormone replacement therapy (HRT) for POI, and other three occurred after assisted reproductive treatment. The results obtained can be used as a guideline for prevention and early detection of late effects with the purpose of enabling better life for long-term survivors of HSCT in the Republic of Croatia.
Document Type: Article
File Description: application/pdf
ISSN: 1849-2177
0024-3477
DOI: 10.26800/lv-141-5-6-17
Access URL: https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=323742
https://doi.org/10.26800/LV-141-5-6-17
https://www.bib.irb.hr/1002164
Accession Number: edsair.doi.dedup.....bedc5a53436becea7ba14ec9ea97de2b
Database: OpenAIRE
Description
Abstract:The number of long-term survivors after allogeneic hematopoietic stem cell transplantation is increasing daily, and late effects of such treatment cause significant quality of life impairment. We analysed the data of 111 long-term survivors that were transplanted at the University Hospital Centre Zagreb in the period between 1986 and 2009. For the investigated population survival median time was 15 years (range 2–33). Our results were similar to those reported by other researchers, and have shown a rising trend over a longer follow-up period. The cumulative incidence of cardiovascular and endocrine complications, solid tumors, chronic graft versus host disease (GvHD), liver, renal and pulmonary diseases is 64%, 42%, 33%, 32%, 28%, 17% and 14%, respectively. Further analysis confirmed that the spontaneous recovery of menstrual cycle was more likely among patiens transplanted in childhood than in adulthood (45% vs 18%). Premature ovarian insufficiency (POI) was detected in 71% of female patients transplanted in adult age. However, five women gave birth to six healthy children in this study population, where two pregnancies occurred after spontaneous recovery of ovarian function, one after the use of hormone replacement therapy (HRT) for POI, and other three occurred after assisted reproductive treatment. The results obtained can be used as a guideline for prevention and early detection of late effects with the purpose of enabling better life for long-term survivors of HSCT in the Republic of Croatia.
ISSN:18492177
00243477
DOI:10.26800/lv-141-5-6-17